Microwave-assisted sample preparation of medicines for determination of elemental impurities in compliance with United States Pharmacopeia: How simple can it be?

2019 ◽  
Vol 1065 ◽  
pp. 1-11 ◽  
Author(s):  
Fernanda C. Pinheiro ◽  
Ariane I. Barros ◽  
Joaquim A. Nóbrega
Keyword(s):  
United States ◽  
Sample Preparation ◽  
United States Pharmacopeia ◽  
Microwave Assisted ◽  
Elemental Impurities ◽  
States Pharmacopeia

A Comparison of Heparin Potency Estimates Obtained by Activated Partial Thromboplastin Time and British Pharmacopoeial Assays

1985 ◽  
Vol 53 (01) ◽  
pp. 116-117 ◽  
Author(s):  
R E Merton ◽  
A D Curtis ◽  
D P Thomas
Keyword(s):  
United States ◽  
Partial Thromboplastin Time ◽  
Close Agreement ◽  
The United States ◽  
Activated Partial Thromboplastin Time ◽  
United States Pharmacopeia ◽  
International Unit ◽  
British Pharmacopoeia ◽  
States Pharmacopeia ◽  
Heparin Preparation

SummaryHeparin samples from five manufacturers were assayed by the revised British Pharmacopoeia (BP) heparin assay and the results compared with those obtained using the activated partial thromboplastin time (APTT) assay. The United States Pharmacopeia (USP) reference heparin preparation and the 4th International Standard (IS) for heparin were also assayed by the two methods relative to the 3rd IS. The results obtained by the revised BP assay were in close agreement with those obtained by the APTT assay for all the heparins that were tested. The assays revealed that there is at least a 10% discrepancy between the International Unit for heparin and the USP unit.

scholarly journals Determination of trans fatty acids in foodstuffs by gas chromatography-mass spectrometry after simultaneous microwave-assisted extraction-esterification

2010 ◽  
Vol 75 (6) ◽  
pp. 803-812 ◽  
Author(s):  
Snezana Kravic ◽  
Zvonimir Suturovic ◽  
Jaroslava Svarc-Gajic ◽  
Zorica Stojanovic ◽  
Mira Pucarevic
Keyword(s):  
Mass Spectrometry ◽  
Sample Preparation ◽  
Preparation Method ◽  
Reference Method ◽  
Gas Chromatography Mass Spectrometry ◽  
Microwave Assisted Extraction ◽  
Sample Preparation Method ◽  
Microwave Assisted ◽  
Assisted Extraction

A sample preparation method based on the simultaneous microwave-assisted extraction-esterification (SMAEE) was developed for the determination of the fatty acid composition of foodstuffs by gas chromatography-mass spectrometry. The proposed sample preparation method was validated by comparison with the reference Soxhlet extraction method followed by derivatisation by ester formation and the same determination step. The fatty acid compositions and the extraction efficiencies obtained using the proposed SMAEE method and the reference method were statistically similar. The results showed that compared to the conventional method, the SMAEE method offered the advantages of short sample preparation time, low consumption of expensive organic solvents and lower energy consumption. This good agreement between results provided by both the SMAEE and the reference method demonstrates the usefulness of the former as a routine method for the treatment of food samples prior to trans fatty analysis.

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