F-containing initiatior for ultrasensitive fluorescent detection of lung cancer DNA via atom transfer radical polymerization

2020 ◽  
Vol 1094 ◽  
pp. 99-105 ◽  
Author(s):  
Jingyu Zhang ◽  
Qianrui Liu ◽  
Yanyan Ba ◽  
Jiamin Cheng ◽  
Huaixia Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Fluorescent Detection ◽  
Atom Transfer

scholarly journals Electrochemiluminescence immunosensor for cytokeratin fragment antigen 21-1 detection using electrochemically mediated atom transfer radical polymerization

2021 ◽  
Vol 188 (4) ◽  
Author(s):  
Lihe Jian ◽  
Xiaolan Wang ◽  
Lulu Hao ◽  
Yanju Liu ◽  
Huaixia Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Signal Amplification ◽  
Limit Of Detection ◽  
Tumor Biomarker ◽  
Atom Transfer ◽  
Sandwich Type ◽  
Diagnosis Of Lung Cancer ◽  
Antigen Antibody

AbstractThe cytokeratin fragment antigen 21-1 (CYFRA 21-1) protein is a critical tumor biomarker tightly related to non-small cell lung cancer (NSCLC). Herein, we prepared an effective electrochemiluminescence (ECL) immunosensor for CYFRA 21-1 detection using electrochemically mediated atom transfer radical polymerization (eATRP). The CYFRA 21-1 antigen was fixed on the electrode surface by constructing a sandwich type antibody-antigen-antibody immune system. The sensitivity of ECL was improved by using the eATRP reaction. In this method, eATRP was applied to CYFRA 21-1 detection antibody with N-acryloyloxysuccinimide as functional monomer. This is the first time that ECL and eATRP signal amplification technology had been combined. Under the optimized testing conditions, the immunosensor showed a good linear relation in the range from 1 fg mL−1 to 1 μg mL−1 at a limit of detection of 0.8 fg mL−1 (equivalent to ~ 134 molecules in a 10 μL sample). The ECL immunosensing system based on eATRP signal amplification technology provided a new way for rapid diagnosis of lung cancer by detecting CYFRA 21-1. Graphical abstract

Redox Responsive Behavior of Thiol/Disulfide-Functionalized Star Polymers Synthesized via Atom Transfer Radical Polymerization

2010 ◽  
Vol 43 (9) ◽  
pp. 4133-4139 ◽  
Author(s):  
Jun Kamada ◽  
Kaloian Koynov ◽  
Cathrin Corten ◽  
Azhar Juhari ◽  
Jeong Ae Yoon ◽  
...  
Keyword(s):  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Star Polymers ◽  
Atom Transfer ◽  
Redox Responsive ◽  
Responsive Behavior

Simplified Electrochemically Mediated Atom Transfer Radical Polymerization using a Sacrificial Anode

2015 ◽  
Vol 54 (8) ◽  
pp. 2388-2392 ◽  
Author(s):  
Sangwoo Park ◽  
Paweł Chmielarz ◽  
Armando Gennaro ◽  
Krzysztof Matyjaszewski
Keyword(s):  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Atom Transfer ◽  
Sacrificial Anode
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