Ultrasensitive fluorescent detection of HTLV-II DNA based on magnetic nanoparticles and atom transfer radical polymerization signal amplification

Talanta ◽  
2020 ◽  
Vol 207 ◽  
pp. 120290 ◽  
Author(s):  
Xiaoke Zheng ◽  
Liying Zhao ◽  
Dongxiao Wen ◽  
Xiaolan Wang ◽  
Huaixia Yang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Signal Amplification ◽  
Fluorescent Detection ◽  
Atom Transfer

F-containing initiatior for ultrasensitive fluorescent detection of lung cancer DNA via atom transfer radical polymerization

2020 ◽  
Vol 1094 ◽  
pp. 99-105 ◽  
Author(s):  
Jingyu Zhang ◽  
Qianrui Liu ◽  
Yanyan Ba ◽  
Jiamin Cheng ◽  
Huaixia Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Fluorescent Detection ◽  
Atom Transfer

scholarly journals Electrochemiluminescence immunosensor for cytokeratin fragment antigen 21-1 detection using electrochemically mediated atom transfer radical polymerization

2021 ◽  
Vol 188 (4) ◽  
Author(s):  
Lihe Jian ◽  
Xiaolan Wang ◽  
Lulu Hao ◽  
Yanju Liu ◽  
Huaixia Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Signal Amplification ◽  
Limit Of Detection ◽  
Tumor Biomarker ◽  
Atom Transfer ◽  
Sandwich Type ◽  
Diagnosis Of Lung Cancer ◽  
Antigen Antibody

AbstractThe cytokeratin fragment antigen 21-1 (CYFRA 21-1) protein is a critical tumor biomarker tightly related to non-small cell lung cancer (NSCLC). Herein, we prepared an effective electrochemiluminescence (ECL) immunosensor for CYFRA 21-1 detection using electrochemically mediated atom transfer radical polymerization (eATRP). The CYFRA 21-1 antigen was fixed on the electrode surface by constructing a sandwich type antibody-antigen-antibody immune system. The sensitivity of ECL was improved by using the eATRP reaction. In this method, eATRP was applied to CYFRA 21-1 detection antibody with N-acryloyloxysuccinimide as functional monomer. This is the first time that ECL and eATRP signal amplification technology had been combined. Under the optimized testing conditions, the immunosensor showed a good linear relation in the range from 1 fg mL−1 to 1 μg mL−1 at a limit of detection of 0.8 fg mL−1 (equivalent to ~ 134 molecules in a 10 μL sample). The ECL immunosensing system based on eATRP signal amplification technology provided a new way for rapid diagnosis of lung cancer by detecting CYFRA 21-1. Graphical abstract

Boronic acid functionalized magnetic nanoparticles synthesized by atom transfer radical polymerization and their application for selective enrichment of glycoproteins

RSC Advances ◽  
2016 ◽  
Vol 6 (52) ◽  
pp. 47055-47061 ◽  
Author(s):  
Jiewen Wang ◽  
Xiwen He ◽  
Langxing Chen ◽  
Yukui Zhang
Keyword(s):  
Magnetic Nanoparticles ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Boronic Acid ◽  
Atom Transfer ◽  
Selective Enrichment ◽  
Efficient Approach ◽  
Affinity Ligand ◽  
Functionalized Magnetic Nanoparticles

A facile and efficient approach to synthesize boronate affinity ligand-functionalized magnetic nanoparticles for specific enrichment of glycoproteins via surface-initiated atom transfer radical polymerization (SI-ATRP) has been developed.

Bactericidal magnetic nanoparticles with iodine loaded on surface grafted poly(N-vinylpyrrolidone)

2015 ◽  
Vol 3 (5) ◽  
pp. 840-848 ◽  
Author(s):  
Ai-Nhan Au-Duong ◽  
Duc-Thang Vo ◽  
Cheng-Kang Lee
Keyword(s):  
Magnetic Nanoparticles ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Atom Transfer

Bactericidal magnetic nanoparticles were prepared by complexing iodine with poly(N-vinylpyrrolidone) (PVP) grown at the surface of silica coated magnetic nanoparticles (MNPs) via surface-initiated atom transfer radical polymerization (SI-ATRP).

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