highly sensitive detection
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2022 ◽  
Vol 9 ◽  
Huaxu Zhou ◽  
Yao Ding ◽  
Ruobing Su ◽  
Dongming Lu ◽  
Hongliang Tang ◽  

Convenient and sensitive detection of active analytes in complex matrix is crucial in biological, medical, and environmental analysis. Silica nanochannel array film (SNF) equipped electrochemical sensors have shown excellent anti-fouling performance in direct analysis of complex samples. In this work, we demonstrated an electrochemical sensor with anti-fouling performance for highly sensitive detection of acetaminophen (APAP) based on SNF supported by ß-cyclodextrin-graphene (CDG) nanocomposite modified Au film electrode (AuF). Because of their rich surface hydroxyls and 2D lamellar structure, CDG on AuF can serve as the nanoadhesive for compact binding SNF, which can be grown by electrochemical assisted self-assembly method in a few seconds. Attributable to the electrocatalytic property of graphene and the synergistic enrichment from both CD and SNF nanochannels towards analyte, the SNF/CDG/AuF sensor demonstrates sensitive detection of acetaminophen ranged from 0.2 to 50 μM with an ultralow limit-of-detection of 14 nM. Taking advantage of the anti-fouling ability of SNF, the sensor is able to realize accurate and convenient analysis of APAP in commercially available paracetamol tablets.

Biosensors ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 24
Donghoon Kim ◽  
Bo Jin ◽  
Sol-A Kim ◽  
Wonyeong Choi ◽  
Seonghwan Shin ◽  

The highly sensitive detection of peanut allergens (PAs) using silicon-based electrolyte-gated transistors (Si-EGTs) was demonstrated. The Si-EGT was made using a top-down technique. The fabricated Si-EGT showed excellent intrinsic electrical characteristics, including a low threshold voltage of 0.7 V, low subthreshold swing of <70 mV/dec, and low gate leakage of <10 pA. Surface functionalization and immobilization of antibodies were performed for the selective detection of PAs. The voltage-related sensitivity (SV) showed a constant behavior from the subthreshold regime to the linear regime. The current-related sensitivity (SI) was high in the subthreshold regime and then significantly decreased as the drain current increased. The limit of detection (LOD) was calculated to be as low as 25 pg/mL based on SI characteristics, which is the lowest value reported to date in the literature for various sensor methodologies. The Si-EGT showed selective detection of PA through a non-specific control test. These results confirm that Si-EGT is a high-sensitivity and low-power biosensor for PA detection.

2022 ◽  
Shaimah Rinda Sari ◽  
Masayuki Tsushida ◽  
Tetsuya Sato ◽  
Masato Tominaga

Phosphates are well-known groundwater and surface water contaminants, with even modest increases in their concentration contributing to the eutrophication of lakes and coastal waterways and thus potentially harming the environment....

The Analyst ◽  
2022 ◽  
Ying Wang ◽  
Xiaomin Yang ◽  
Lin Pang ◽  
Pengfei Geng ◽  
Fang Mi ◽  

Specific recognition and highly sensitive detection of biomarkers play an essential role in identifying, early diagnosis and prevention of many diseases. Magnetic molecularly imprinted polymers (MMIP) have been widely used...

2022 ◽  
Song Zhao ◽  
Hongbo Jiang ◽  
Chengbin Gong ◽  
Wenjing Qi ◽  
Lianzhe Hu ◽  

A novel fluorescent sensor based on an asymmetric anthracene derivatives (SSAPA) was designed and synthesized. By using this molecule, a rapid and sensitive assay for detecting Tb3+ and ATP in...

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