Variables that modulate the spatial distribution of Trypanosoma cruzi and Trypanosoma evansi in the Brazilian Pantanal

Acta Tropica ◽  
2007 ◽  
Vol 102 (1) ◽  
pp. 55-62 ◽  
Author(s):  
H.M. Herrera ◽  
V. Rademaker ◽  
U.G.P. Abreu ◽  
P.S. D‘Andrea ◽  
A.M. Jansen
Keyword(s):  
Spatial Distribution ◽  
Trypanosoma Cruzi ◽  
Trypanosoma Evansi ◽  
Brazilian Pantanal

scholarly journals Outcomes of Trypanosoma cruzi and Trypanosoma evansi infections on health of Southern coati (Nasua nasua), crab-eating fox (Cerdocyon thous), and ocelot (Leopardus pardalis) in the Brazilian Pantanal

PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0201357 ◽  
Author(s):  
Filipe Martins Santos ◽  
Gabriel Carvalho de Macedo ◽  
Wanessa Teixeira Gomes Barreto ◽  
Luiz Gustavo Rodrigues Oliveira-Santos ◽  
Carolina Martins Garcia ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Trypanosoma Evansi ◽  
Leopardus Pardalis ◽  
Nasua Nasua ◽  
Cerdocyon Thous ◽  
Brazilian Pantanal

scholarly journals Correction: Outcomes of Trypanosoma cruzi and Trypanosoma evansi infections on health of Southern coati (Nasua nasua), crab-eating fox (Cerdocyon thous), and ocelot (Leopardus pardalis) in the Brazilian Pantanal

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0205613 ◽  
Author(s):  
Filipe Martins Santos ◽  
Gabriel Carvalho de Macedo ◽  
Wanessa Teixeira Gomes Barreto ◽  
Luiz Gustavo Rodrigues Oliveira-Santos ◽  
Carolina Martins Garcia ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Trypanosoma Evansi ◽  
Leopardus Pardalis ◽  
Nasua Nasua ◽  
Cerdocyon Thous ◽  
Brazilian Pantanal

scholarly journals Biological and Structural Characterization of Trypanosoma cruzi Phosphodiesterase C and Implications for Design of Parasite Selective Inhibitors

2012 ◽  
Vol 287 (15) ◽  
pp. 11788-11797 ◽  
Author(s):  
Huanchen Wang ◽  
Stefan Kunz ◽  
Gong Chen ◽  
Thomas Seebeck ◽  
Yiqian Wan ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Crystal Structures ◽  
Active Site ◽  
Catalytic Domain ◽  
Trypanosoma Evansi ◽  
Active Site Residues ◽  
Dual Specificity ◽  
Pde Inhibitors ◽  
Starting Model

Trypanosoma cruzi phosphodiesterase C (TcrPDEC) is a potential new drug target for the treatment of Chagas disease but has not been well studied. This study reports the enzymatic properties of various kinetoplastid PDECs and the crystal structures of the unliganded TcrPDEC1 catalytic domain and its complex with an inhibitor. Mutations of PDEC during the course of evolution led to inactivation of PDEC in Trypanosoma brucei/Trypanosoma evansi/Trypanosoma congolense, whereas the enzyme is active in all other kinetoplastids. The TcrPDEC1 catalytic domain hydrolyzes both cAMP and cGMP with a Km of 23.8 μm and a kcat of 31 s−1 for cAMP and a Km of 99.1 μm and a kcat of 17 s−1 for cGMP, thus confirming its dual specificity. The crystal structures show that the N-terminal fragment wraps around the TcrPDEC catalytic domain and may thus regulate its enzymatic activity via direct interactions with the active site residues. A PDE5 selective inhibitor that has an IC50 of 230 nm for TcrPDEC1 binds to TcrPDEC1 in an orientation opposite to that of sildenafil. This observation, together with the screen of the inhibitory potency of human PDE inhibitors against TcrPDEC, implies that the scaffold of some human PDE inhibitors might be used as the starting model for design of parasite PDE inhibitors. The structural study also identified a unique parasite pocket that neighbors the active site and may thus be valuable for the design of parasite-specific inhibitors.

scholarly journals Complexity and multi-factoriality of Trypanosoma cruzi sylvatic cycle in coatis, Nasua nasua (Procyonidae), and triatomine bugs in the Brazilian Pantanal

2016 ◽  
Vol 9 (1) ◽  
Author(s):  
Fernanda Moreira Alves ◽  
Juliane Saab de Lima ◽  
Fabiana Lopes Rocha ◽  
Heitor Miraglia Herrera ◽  
Guilherme de Miranda Mourão ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Sylvatic Cycle ◽  
Nasua Nasua ◽  
Triatomine Bugs ◽  
Brazilian Pantanal

TESA-blot for the diagnosis of Chagas disease in dogs from co-endemic regions for Trypanosoma cruzi, Trypanosoma evansi and Leishmania chagasi

Acta Tropica ◽  
2009 ◽  
Vol 111 (1) ◽  
pp. 15-20 ◽  
Author(s):  
E.S. Umezawa ◽  
A.I. Souza ◽  
V. Pinedo-Cancino ◽  
M. Marcondes ◽  
A. Marcili ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Trypanosoma Evansi ◽  
Leishmania Chagasi

scholarly journals VALORES HEMATOLÓGICOS DE LOBINHOS (Cerdocyon thous) DO PANTANAL, MATO GROSSO DO SUL, BRASIL NATURALMENTE INFECTADOS E NÃO INFECTADOS POR Trypanosoma cruzi e T. evansi

2019 ◽  
Vol 20 ◽  
Author(s):  
Filipe Martins Santos ◽  
Gabriel Carvalho de Macedo ◽  
Wanessa Teixeira Gomes Barreto ◽  
Wesley Arruda Gimenes Nantes ◽  
William Oliveira de Assis ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Trypanosoma Evansi ◽  
Mato Grosso ◽  
Cerdocyon Thous ◽  
Mato Grosso Do Sul

Resumo O objetivo do trabalho foi avaliar a influência do sexo, da sazonalidade e de infecções por Trypanosoma cruzi e Trypanosoma evansi nos valores hematológicos de lobinhos (Cerdocyon thous) que habitam o Pantanal Sul-Mato-Grossense. Entre novembro de 2015 e outubro de 2016, foram amostrados 48 lobinhos. Os valores hematológicos mensurados foram as contagens de eritrócitos e leucócitos, volume globular e volume corpuscular médio. Consideramos como parasitados os animais positivos para T.cruzi e T. evansi em qualquer um dos testes diagnósticos utilizados. Observamos que sete (14.5%) lobinhos encontraram-se parasitados somente por T.cruzi, sete por T. evansi, e nove (19%) estavam coinfectados. Os animais parasitados por T.cruzi mostraram um aumento significativo das contagens de leucócitos (14.7 x 103) em relação aos animais não parasitados (10.4 x 103), parasitados por T. evansi (12.4 x 103) e coinfectados (12.9 x 103). Observamos diferença significativa em relação aos valores médios de eritrócitos e volume corpuscular médio entre os períodos de cheia e seca: 2.6 x 106 e 165, e 3.4 x 106 e 132, respectivamente. Todos apresentaram macrocitose não confirmada morfologicamente.

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