Sialic acid (SA)-modified selenium nanoparticles coated with a high blood–brain barrier permeability peptide-B6 peptide for potential use in Alzheimer’s disease

2015 ◽  
Vol 25 ◽  
pp. 172-183 ◽  
Author(s):  
Tiantian Yin ◽  
Licong Yang ◽  
Yanan Liu ◽  
Xianbo Zhou ◽  
Jing Sun ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Sialic Acid ◽  
Blood Brain Barrier ◽  
Selenium Nanoparticles ◽  
Brain Barrier ◽  
Barrier Permeability ◽  
Blood Brain Barrier Permeability ◽  
Blood Brain ◽  
Brain Barrier Permeability ◽  
Potential Use

The Blood–Brain Barrier in Cognitive Decline and Alzheimer’s Disease

2020 ◽  
pp. 261-273
Author(s):  
Daniel A. Nation ◽  
Elissa McIntosh
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Brain Barrier ◽  
Neurovascular Unit ◽  
Brain Barrier ◽  
Barrier Permeability ◽  
Blood Brain Barrier Permeability ◽  
Blood Brain ◽  
Brain Barrier Permeability ◽  
Brain Tissue Damage

The neurovascular unit is a multicellular organ that has attracted recent attention as a key microvascular regulator of cerebral blood flow and blood–brain barrier permeability that is implicated in homeostatic and pathological processes impacting cognitive function. Breakdown of the blood–brain barrier invariably causes brain tissue damage and dysfunction due to influx of toxic blood proteins, cells, ions and metals. Clinical studies employing markers of blood–brain barrier permeability suggest an important role in vascular and neurodegenerative dementias. The chapter discusses how the introduction of new neuroimaging and biomarker technologies has opened new pathways of investigation into the blood–brain function in Alzheimer’s disease.

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