Binding loop of sunflower trypsin inhibitor 1 serves as a design motif for proteolysis-resistant antimicrobial peptides

2021 ◽  
Author(s):  
Chensi Wang ◽  
Changxuan Shao ◽  
Yuxin Fang ◽  
Jiajun Wang ◽  
Na Dong ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Trypsin Inhibitor ◽  
Binding Loop

High-resolution structure of bovine pancreatic trypsin inhibitor with altered binding loop sequence

2000 ◽  
Vol 295 (5) ◽  
pp. 1237-1249 ◽  
Author(s):  
Honorata Czapinska ◽  
Jacek Otlewski ◽  
Szymon Krzywda ◽  
George M Sheldrick ◽  
Mariusz Jaskólski
Keyword(s):  
High Resolution ◽  
Trypsin Inhibitor ◽  
Bovine Pancreatic Trypsin Inhibitor ◽  
Loop Sequence ◽  
Pancreatic Trypsin Inhibitor ◽  
High Resolution Structure ◽  
Binding Loop ◽  
Resolution Structure

scholarly journals Modifications outside the proteinase binding loop in Cucurbita maxima trypsin inhibitor III (CMTI-III) analogues change the binding energy with bovine β-trypsin

FEBS Letters ◽  
1998 ◽  
Vol 436 (2) ◽  
pp. 174-178 ◽  
Author(s):  
Anna Jaśkiewicz ◽  
Katarzyna Lis ◽  
Jan Różycki ◽  
Gotfryd Kupryszewski ◽  
Krzysztof Rolka ◽  
...  
Keyword(s):  
Binding Energy ◽  
Trypsin Inhibitor ◽  
Cucurbita Maxima ◽  
Binding Loop

Divergent Protein Synthesis of Bowman–Birk Protease Inhibitors, their Hydrodynamic Behavior and Co-crystallization with α-Chymotrypsin

Synlett ◽  
2017 ◽  
Vol 28 (15) ◽  
pp. 1901-1906 ◽  
Author(s):  
Christian Tornøe ◽  
Eva Johansson ◽  
Per-Olof Wahlund
Keyword(s):  
Crystal Structure ◽  
Protein Synthesis ◽  
Trypsin Inhibitor ◽  
Native Chemical Ligation ◽  
Protein Fold ◽  
Hydrodynamic Behavior ◽  
Chemical Ligation ◽  
Synthesis Strategy ◽  
Self Association ◽  
Binding Loop

A divergent protein synthesis strategy was executed to effectively synthesize Bowman–Birk protease inhibitor (BBI) analogues using native chemical ligation of peptide hydrazides. Grafting selected residues from a potent trypsin inhibitor, sunflower trypsin inhibitor-1, onto the α-chymotrypsin-binding loop of BBI, resulted in a fourfold improvement of α-chymotrypsin inhibition. The crystal structure of a synthetic BBI analogue co-crystallized with α-chymotrypsin confirmed the correct protein fold and showed a similar overall structure to unmodified BBI in complex with α-chymotrypsin. Dynamic light scattering showed that C-terminal truncation of BBI led to increased self-association.

Antimicrobial peptides in COPD

Pneumologie ◽  
2009 ◽  
Vol 63 (S 01) ◽  
Author(s):  
G Günther ◽  
E Andresen ◽  
J Bullwinkel ◽  
C Lange ◽  
H Heine
Keyword(s):  
Antimicrobial Peptides

The role of the N34S mutation in the trypsin inhibitor gene SPINK1 in patients with chronic pancreatitis from Romania

2009 ◽  
Vol 47 (06) ◽  
Author(s):  
B Diaconu ◽  
A Schneider ◽  
R Pfützer ◽  
T Mocan ◽  
M Scăfaru ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Trypsin Inhibitor ◽  
N34s Mutation ◽  
Inhibitor Gene
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