scholarly journals Insomnia in alcohol dependent subjects is associated with greater psychosocial problem severity

2015 ◽  
Vol 50 ◽  
pp. 165-172 ◽  
Author(s):  
Ninad S. Chaudhary ◽  
Kyle M. Kampman ◽  
Henry R. Kranzler ◽  
Michael A. Grandner ◽  
Swarnalata Debbarma ◽  
...  
2021 ◽  
Vol 12 ◽  
Author(s):  
Hugh Piercy ◽  
Victoria Manning ◽  
Petra K. Staiger

Introduction: Alcohol approach bias, the tendency to automatically move toward alcohol cues, has been observed in people who drink heavily. However, surprisingly, some alcohol-dependent patients demonstrate an alcohol avoidance bias. This inconsistency could be explained by the clinical or demographic profile of the population studied, yet this has not been examined in approach bias modification (ABM) trials to date. We aimed to determine the proportion of patients with an approach or avoidance bias, assess whether they differ on demographic and drinking measures, and to examine the clinical correlates of approach bias.Method: These research questions were addressed using baseline data from 268 alcohol-dependent patients undergoing inpatient withdrawal treatment who then went on to participate in a trial of ABM.Results: At trial entry (day 3 or 4 of inpatient withdrawal), 155 (57.8%) had an alcohol approach bias and 113 (42.2%) had an avoidance bias. These two groups did not differ on any demographic or relevant drinking measures. Approach bias was significantly and moderately associated with total standard drinks consumed in the past 30 days (r = 0.277, p = 0.001) but no other indices of alcohol consumption or problem severity.Conclusion: Whilst the majority of alcohol-dependent patients showed an alcohol approach bias, those with an avoidance bias did not differ in demographic or clinical characteristics, and the strength of approach bias related only to recent consumption. Further research is needed to develop more accurate and personally tailored measures of approach bias, as these findings likely reflect the poor reliability of standard approach bias measures.


2013 ◽  
Author(s):  
A. Gemelli ◽  
S. Querci ◽  
A. M. Lugli ◽  
F. Canfora ◽  
C. Annovi ◽  
...  
Keyword(s):  

Author(s):  
Eugene Schneider ◽  
Khalil Saikali ◽  
Daozhi Zhang ◽  
Allyson Gage ◽  
Jeanne Vander Zanden
Keyword(s):  

2013 ◽  
Author(s):  
Giselle M. Medina-Velez ◽  
Nydia M. Cappas-Ortiz ◽  
Omar Alicea-Velez ◽  
Angelica Montalvo-Santiago ◽  
Emily M. Perez-Torres ◽  
...  

2009 ◽  
Vol 47 (01) ◽  
Author(s):  
L Ciuclan ◽  
C Stump ◽  
I Ilkavets ◽  
H Weng ◽  
MV Singer ◽  
...  

2009 ◽  
Vol 47 (09) ◽  
Author(s):  
LI Ciuclan ◽  
S Ehnert ◽  
I Ilkavets ◽  
H Weng ◽  
H Gaitantzi ◽  
...  

2013 ◽  
Vol 46 (06) ◽  
Author(s):  
D Wedekind ◽  
B Bandelow ◽  
DJ Stein ◽  
U Havemann-Reinecke ◽  
S Bloch ◽  
...  

2007 ◽  
Vol 45 (01) ◽  
Author(s):  
L Ciuclan ◽  
P Godoy ◽  
S Ehnert ◽  
H Weng ◽  
MV Singer ◽  
...  

2019 ◽  
Author(s):  
Sean Lund ◽  
Taylor Courtney ◽  
Gavin Williams

Isoprenoids are a large class of natural products with wide-ranging applications. Synthetic biology approaches to the manufacture of isoprenoids and their new-to-nature derivatives are limited due to the provision in Nature of just two hemiterpene building blocks for isoprenoid biosynthesis. To address this limitation, artificial chemo-enzymatic pathways such as the alcohol-dependent hemiterpene pathway (ADH) serve to leverage consecutive kinases to convert exogenous alcohols to pyrophosphates that could be coupled to downstream isoprenoid biosynthesis. To be successful, each kinase in this pathway should be permissive of a broad range of substrates. For the first time, we have probed the promiscuity of the second enzyme in the ADH pathway, isopentenyl phosphate kinase from Thermoplasma acidophilum, towards a broad range of acceptor monophosphates. Subsequently, we evaluate the suitability of this enzyme to provide non-natural pyrophosphates and provide a critical first step in characterizing the rate limiting steps in the artificial ADH pathway.<br>


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