Prediction of Glaucoma Progression with Structural Parameters: Comparison of Optical Coherence Tomography and Clinical Disc Parameters

PurposeTo evaluate the effect of baseline test selection on progression detection of circumpapillary retinal nerve fibre layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) in glaucomatous eyes by optical coherence tomography (OCT)-guided progression analysis (GPA).MethodsA total of 53 eyes with either RNFL or GCIPL progression determined using OCT-GPA were included. Three different baseline conditions were created by dividing eight serial OCT tests from each eye into three sets. Specifically, these sets presented baseline tests at exams 1–2 (1st set), 2–3 (2nd set) and 3–4 (3rd set), respectively. Agreement on progression detection was defined as the presence of ‘Possible Loss’ or ‘Likely Loss’ in the 2nd or 3rd sets at the same location in the 1st set.ResultsThe proportion of eyes with agreement on progression detection was 47.1%, 20.0% and 31.0% for RNFL ‘thickness map progression’, ‘thickness profiles progression’ and ‘average thickness progression’, respectively. In GCIPL ‘thickness map progression’ and ‘average thickness progression’, 53.8% and 62.8% of eyes showed agreement, respectively. Eyes with disagreement showed a greater change in thickness (slope of change in the 3rd set−1st set) compared to the eyes with agreement (p<0.05), with the exception of RNFL ‘thickness profiles progression’ (p=0.064).ConclusionGlaucoma progression detection by OCT-GPA was affected by baseline test selection, especially in eyes with a greater reduction in progression. GCIPL thickness was less influenced by baseline test selection compared to RNFL thickness.

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Microperimetry in age-related macular degeneration: association with macular morphology assessed by optical coherence tomography

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2018-313316 ◽

2019 ◽

pp. bjophthalmol-2018-313316 ◽

Cited By ~ 1

Author(s):

Miin Roh ◽

Inês Laíns ◽

Hyun Joon Shin ◽

Dong Ho Park ◽

Steven Mach ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Macular Degeneration ◽

Structural Parameters ◽

Multivariable Analysis ◽

Age Related Macular Degeneration ◽

Retinal Sensitivity ◽

Optical Coherence ◽

Mixed Effect ◽

Integrity Assessment ◽

Age Related

Background/aimsMicroperimetry is a technique that is increasingly used to assess visual function in age-related macular degeneration (AMD). In this study, we aimed to evaluate the relationship between retinal sensitivity measured with macular integrity assessment (MAIA) microperimetry and optical coherence tomography (OCT)-based macular morphology in AMD.MethodsProspective, cross-sectional study. All participants were imaged with colour fundus photographs used for AMD staging (Age-Related Eye Disease Study scale), spectral-domain OCT (Spectralis, Heidelberg, Germany) and swept-source OCT (Topcon, Japan). Threshold retinal sensitivity of the central 10° diameter circle was assessed with the full-threshold, 37-point protocol of the MAIA microperimetry device (Centervue, Italy). Univariable and multivariable multilevel mixed-effect linear regression models were used for analysis.ResultsWe included 102 eyes with AMD and 46 control eyes. Multivariable analysis revealed that older age (p<0.0001), advanced AMD stage (p<0.0001) and reduced retinal thickness (p<0.0001) were associated with decreased mean retinal sensitivity. No associations were found between choroidal thickness and retinal sensitivity within the macula. Within the 10° diameter circle of the macula, the presence of ellipsoid disruption, subretinal fluid, atrophy and fibrosis, and outer retinal tubulation on OCT images was also associated with decreased retinal sensitivity (all p<0.05).ConclusionsThere is an association between TRS as determined by MAIA microperimetry and several OCT structural parameters across various stages of AMD. This study highlights the relevance of microperimetry as a functional outcome measure for AMD.

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Оptical coherence tomography and optical coherence tomography-angiography in determining the progression of glaucoma

POINT OF VIEW EAST – WEST ◽

10.25276/2410-1257-2021-1-26-31 ◽

2021 ◽

pp. 26-31

Author(s):

N.I. Kurysheva ◽

◽

A.D. Nikitina ◽

Keyword(s):

Optical Coherence Tomography ◽

Functional Assessment ◽

Oct Angiography ◽

Ganglion Cell Complex ◽

Automated Perimetry ◽

Optical Coherence ◽

Complex Dynamic ◽

Glaucoma Progression ◽

Primary Glaucoma ◽

Sd Oct

Purpose. To study the role of optical coherence tomography (OCT) and OCT angiography (OCTA) in the detection of the primary glaucoma progression. Material and methods. The prospective study of 128 patients with primary glaucoma (128 eyes), conducted from 2015 to 2019, included at least 6 standard automated perimetry (SAP) and spectral-domain OCT (SD-OCT) examinations in each patient; OCTA was also used during the last year of observation. To determine the disease progression, the trend and event analysis using the Humphrey Field Analyzer was performed. The fact and rate of thinning of the retinal nerve fiber layer (RNFL) and its ganglion cell complex (GCC) were evaluated. If they had a trend of significant (p < 0.05) thinning, the eye was classified as having the SD-OCT progression. The values of corneal-compensated IOP were also considered: minimal (IOPmin) and peak (IOPmax). Results. Glaucoma progression was detected in 79 eyes. The isolated use of SAP allows detecting the progression only in 2.3% cases, SD-OCT - in 37.5%, among them the isolated assessment of GCC amounted to 7.8%, and RNFL – to 5.5%. The complex dynamic morphological and functional assessment increased the possibility of progression detection up to 61.7%. Progression was related to the stage of glaucoma damage at the moment of diagnosis: for the perimetry index PSD p=0.025, for the focal loss volume of GCC p=0.024, as well as with the level of minimal IOP (p=0.04). All patients with progression have shown the vessel density decrease in the peripapillary retina and parafovea. Conclusion. SD-OCT plays an important role in detecting the progression of glaucoma. The complex dynamic morphological and functional assessment allows detecting the progression in over half of patients. Progression is associated with the initial stage of glaucoma and an insufficient IOP decrease during treatment, accompanied by retinal microcirculation deterioration. Key words: primary, glaucoma progression, optical coherence tomography, OCT-angiography, IOP.

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