Abstract
Background
Pregabalin is a gamma-aminobutyric acid analog which seems to be effective
in different neuropathic pains, as well as in incisional and inflammatory
injuries. This study evaluated the effectiveness and safety of pregabalin on
pain relief post herniorrhaphy.
Methods
In this randomized clinical trial, 60 men were chosen for unilateral
inguinal herniorrhaphy under spinal anesthesia. The participants were randomly
divided into two groups. The investigation (pregabalin) group received 300 mg
of oral pregabalin 2 h before and 150 mg of pregabalin 12 and 24 h after
surgery in addition to routine postoperative medication and 1 mg/kg of
pethidine as needed. The control (placebo) group received placebo capsules
similar to the investigation group, as well as routine medication and 1 mg/kg
of pethidine as needed. All surgeries were done with the same technique.
Post-surgery pain was evaluated in the walking and lying positions with a
visual analog scale at 12 and 24 h and at 3 and 7 days after the surgery.
Pethidine consumption and adverse effects of pregabalin were also
assessed.
Results
The investigation group had less pain and lower visual analog scale scores
at 12 and 24 h and also at 3 days after surgery and consumed less pethidine
compared to the control group (p<0.05).
Conclusions
Pregabalin reduces pain and opioid consumption in the first 3 days after
surgery. The adverse effects of pregabalin are limited to the first 12 h after
surgery. Pregabalin can be suggested for pain relief, but it should be used
with caution in the elderly.