Chronic villitis in untreated neonatal alloimmune thrombocytopenia: An etiology for severe early intrauterine growth restriction and the effect of intravenous immunoglobulin therapy

2005 ◽  
Vol 193 (3) ◽  
pp. 1100-1104 ◽  
Author(s):  
Janyne Althaus ◽  
Edward G. Weir ◽  
Fred Askin ◽  
Thomas S. Kickler ◽  
Karin Blakemore
Keyword(s):  
Intravenous Immunoglobulin ◽  
Intrauterine Growth Restriction ◽  
Immunoglobulin Therapy ◽  
Growth Restriction ◽  
Intravenous Immunoglobulin Therapy ◽  
Intrauterine Growth ◽  
Chronic Villitis ◽  
Alloimmune Thrombocytopenia

Passively Acquired Treponemal Antibody From Intravenous Immunoglobulin Therapy in aPregnant Patient

2002 ◽  
Vol 126 (10) ◽  
pp. 1237-1238 ◽  
Author(s):  
Karen Q. Rossi ◽  
James R. Nickel ◽  
Mary E. Wissel ◽  
Richard W. O'Shaughnessy
Keyword(s):  
Intravenous Immunoglobulin ◽  
Immunoglobulin Therapy ◽  
Absorption Test ◽  
Rapid Plasma Reagin ◽  
Syphilis Infection ◽  
Intravenous Immunoglobulin Therapy ◽  
Antibody Absorption ◽  
History Of ◽  
Fluorescence Antibody ◽  
Alloimmune Thrombocytopenia

Abstract Intravenous immunoglobulin is purified, concentrated immunoglobulin G antibodies pooled from human blood donors. The passive transmission of various antibodies from intravenous immunoglobulin has been reported. However, to the best of our knowledge, there are no reports of acquisition of treponemal antibody from immunoglobulin therapy. A woman with a pregnancy complicated by neonatal alloimmune thrombocytopenia was treated with intravenous immunoglobulin to manage her fetal thrombocytopenia. The patient had no history of a syphilis infection. The patient's blood was screened for syphilis antibodies regularly and routinely because she donated platelets for transfusion to her fetus. During her intravenous immunoglobulin treatments, a positive result on a fluorescence antibody absorption test was confirmed, but the result on a rapid plasma reagin test was negative. Eleven weeks after her final dose, results of the fluorescence antibody absorption test were negative, with a negative rapid plasma reagin test result, suggesting passive acquisition of the treponemal antibody. Clinicians and pathologists must be aware of the possible acquisition of this antibody during the treatment and counseling of patients receiving intravenous immunoglobulin.

Pathological features of the sequence in pregnant women with delayed fetal growth

2019 ◽  
pp. 50-54
Author(s):  
V.O. Golyanovskiy ◽  
◽  
Ye.O. Didyk ◽  
Keyword(s):  
Pregnant Women ◽  
Intrauterine Growth Restriction ◽  
Normal Development ◽  
Intrauterine Infection ◽  
Normal Pregnancy ◽  
Growth Restriction ◽  
Control Group ◽  
Intrauterine Growth ◽  
Increased Risk ◽  
Infection And Inflammation

Pregnant women with intrauterine growth restriction (IUGR) have an increased risk of adverse perinatal and long-term complications compared with the birth of children with normal body weight. Thus, IUGR is one of the main challenges for the global health system, especially in poor and developing countries. Morpho-functional studies of the placentas help in determining the causes of IUGR, and therefore, timely prevent complications in pregnant women with IUGR. The objective: The purpose of this study is to investigate various morphometric and pathomorphological changes in the placenta, including inflammatory, in cases of IUGR, and to establish a correlation of these results with the etiology and complications for the fetus. Materials and methods. In the current study, 54 placentas of the fetuses with IUGR (the main group) were compared with 50 placentas of the fetuses with normal development (control group). The criteria for the inclusion of IUGR were gestational age more than 30 weeks and all fetuses with a weight less than 10th percentile for this period of pregnancy. The placenta material was studied pathomorphologically with laboratory screening for infection and inflammation. Similarly, the results were determined for placentas of the fetuses with normal development compared to placentas with IUGR. Results. The placenta study showed the presence of calcification in the case of IUGR, as well as in the case of prolonged pregnancy. However, calcification of the placenta in the case of IUGR was more progressive compared with placenta in the normal pregnancy. In addition, the presence of intrauterine infection and inflammation was observed, which could also lead to an adverse outcome for the further progression of pregnancy with IUGR. Conclusion. A comparative macro- and microscopic pathomorphological study of the placentas in the two groups has shown a significant increase in the pathological changes in all the anatomical structures of the fetuses with IUGR. Key words: Intrauterine growth restriction (IUGR), fetal weight, pathomorphological changes of the placenta.

Efficacy of Intravenous Immunoglobulin Therapy in Childhood Atopic Dermatitis

2012 ◽  
Vol 18 (1) ◽  
pp. 26-31
Author(s):  
Eun Kyeong Yeon ◽  
A Young Park ◽  
Sanghoon Chae ◽  
Seung Soo Kim ◽  
Kyeong Bae Park ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Intravenous Immunoglobulin ◽  
Immunoglobulin Therapy ◽  
Intravenous Immunoglobulin Therapy

Pulmonary Thromboembolism Induced by Intravenous Immunoglobulin Therapy for Stevens-Johnson Syndrome : A Case Report

2019 ◽  
Vol 81 (3) ◽  
pp. 170-174 ◽  
Author(s):  
Taketoshi IDE ◽  
Maiko OHNO ◽  
Takamichi ITO ◽  
Karin TSUKAMOTO ◽  
Anna HIRANO ◽  
...  
Keyword(s):  
Case Report ◽  
Intravenous Immunoglobulin ◽  
Pulmonary Thromboembolism ◽  
Immunoglobulin Therapy ◽  
Stevens Johnson Syndrome ◽  
Intravenous Immunoglobulin Therapy ◽  
Johnson Syndrome
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