Postpartum headache: is your work-up complete?

Während eine allergologische Abklärung im Work-Up eines Asthma bronchiale inbegriffen sein sollte, wird die chronisch obstruktive Pneumopathie nicht spontan mit einer atopischen Diathese in Zusammenhang gebracht. Anamnese, Klinik, das Vorhandensein weiterer atopischer Krankheiten sowie Prickteste und die serologische Messung von spezifischen IgE-Antikörpern geben Hinweise auf eine allergische Genese einer akuten oder chronischen Lungenkrankheit. Der Stickoxidwert in der Ausatemluft (FeNO-Messung) kann durch die Infiltration von Eosinophilen in die Bronchialwand beim allergischen Phänotyp des Asthma bronchiale erhöht sein (TH2-gewichteter Phänotyp). Eine Abhängigkeit der Beschwerden vom Arbeitsplatz muss evaluiert werden. Neben dem allergischen Typ des Asthma bronchiale soll auch an eine Aspirin-exacerbated-respiratory disease (AERD) gedacht werden. Aufgrund der überlappenden pathophysiologischen Grundlagen und der Symptomatik zwischen Asthma bronchiale und der chronisch obstruktiven Pneumopathie ist die Zuweisung zum Allergologen allenfalls auch bei einem COPD-Patienten indiziert.

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Extensive Work-Up for IBS Rarely Needed

Clinical Psychiatry News ◽

10.1016/s0270-6644(10)70160-0 ◽

2010 ◽

Vol 38 (3) ◽

pp. 42

Author(s):

NANCY WALSH

Keyword(s):

Work Up

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Guideline for radioimmunotherapy of rituximab relapsed or refractory CD20+ follicular B-cell nonHodgkin´s lymphoma

Nuklearmedizin ◽

10.1055/s-0038-1625198 ◽

2004 ◽

Vol 43 (05) ◽

pp. 171-176 ◽

Cited By ~ 3

Author(s):

T. Behr ◽

F. Grünwald ◽

W. H. Knapp ◽

L. Trümper ◽

C. von Schilling ◽

...

Keyword(s):

Quality Control ◽

Quality Management ◽

Medical Physics ◽

Essential Elements ◽

Background Information ◽

After Care ◽

Complete Treatment ◽

Close Cooperation ◽

Work Up

Summary:This guideline is a prerequisite for the quality management in the treatment of non-Hodgkin-lymphomas using radioimmunotherapy. It is based on an interdisciplinary consensus and contains background information and definitions as well as specified indications and detailed contraindications of treatment. Essential topics are the requirements for institutions performing the therapy. For instance, presence of an expert for medical physics, intense cooperation with all colleagues committed to treatment of lymphomas, and a certificate of instruction in radiochemical labelling and quality control are required. Furthermore, it is specified which patient data have to be available prior to performance of therapy and how the treatment has to be carried out technically. Here, quality control and documentation of labelling are of greatest importance. After treatment, clinical quality control is mandatory (work-up of therapy data and follow-up of patients). Essential elements of follow-up are specified in detail. The complete treatment inclusive after-care has to be realised in close cooperation with those colleagues (haematology-oncology) who propose, in general, radioimmunotherapy under consideration of the development of the disease.

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Surgery for Skull Base Malignancies-Preoperative Work-Up to Minimize Complications

Skull Base ◽

10.1055/s-2008-1093187 ◽

2008 ◽

Vol 18 (S 01) ◽

Author(s):

Andrew King ◽

Stephen MacNally ◽

Jarod Homer ◽

Richard Ramsden ◽

Shakeel Saeed ◽

...

Keyword(s):

Skull Base ◽

Preoperative Work Up ◽

Work Up

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Rapidly progressive glomerulonephritis as presenting feature of systemic lupus erythematosus in a Bangladeshi male patient: a rare case report

BIRDEM Medical Journal ◽

10.3329/birdem.v10i2.47748 ◽

2020 ◽

Vol 10 (2) ◽

pp. 137-138

Author(s):

Samiha Haque ◽

Ishrat Jahan ◽

Tufayel Ahmed Chowdhury ◽

Muhammad Abdur Rahim ◽

Mehruba Alam Ananna ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Venous Pressure ◽

Rapidly Progressive Glomerulonephritis ◽

Initial Response ◽

Systemic Lupus ◽

Renal Manifestation ◽

Rare Case Report ◽

Diagnostic Work ◽

Work Up

Rapidly progressive glomerulonephritis is one of the most dramatic and tragic presentations of lupus nephritis (LN) or renal manifestation of systemic lupus erythematosus (SLE). A 35-year-old Bangladeshi gentleman presented with worsening oedema, scanty, high colored, frothy urine and deteriorating renal function. He had puffy face, anaemia, oedema, normal jugular venous pressure (JVP), high blood pressure (150/90 mm Hg), ascites and bilateral pleural effusions. Diagnostic work-up confirmed SLE with class IV LN. His initial response to specific therapy showed improvement Birdem Med J 2020; 10(2): 137-138

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PHENOLIC METABOLITES OF DL-NORGESTREL: A METHOD FOR THE REMOVAL OF 1-HYDROXYLATED METABOLITES, POTENTIAL SOURCES OF PHENOLIC ARTIFACTS

Acta Endocrinologica ◽

10.1530/acta.0.0760789 ◽

1974 ◽

Vol 76 (4) ◽

pp. 789-800 ◽

Cited By ~ 7

Author(s):

Samuel F. Sisenwine ◽

Ann L. Liu ◽

Hazel B. Kimmel ◽

Hans W. Ruelius

Keyword(s):

Urinary Metabolites ◽

Ion Exchange Resin ◽

Gas Chromatography Mass Spectrometry ◽

Phenolic Metabolites ◽

Hydroxylated Metabolites ◽

Analytical Work ◽

Potential Sources ◽

Alkaline Conditions ◽

Artifact Formation ◽

Work Up

ABSTRACT The identification of 1β-hydroxynorgestrel among the urinary metabolites of dl-norgestrel and the facile transformation of this compound under mild alkaline conditions to a potentially oestrogenic phenol provide an experimental basis for the conclusion advanced by others that the oestrogens present in the urine of subjects treated with synthetic progestens are artifacts formed during analytical work-up. A method has been devised which eliminates 1-hydroxylated metabolites as potential sources of phenolic artifacts. This method is based on the reduction by NaBH4 of the 1-hydroxy-4-en-3-one grouping in the A ring thereby excluding the possibility of aromatization during later fractionation on a basic ion exchange resin that separates neutral from phenolic metabolites. In the urines of women treated with 14C-dl-nogestrel, only 0.17–0.27% of the dose is found to have phenolic properties when this method is used. Two of the phenolic metabolites, 18-homoethynyloestradiol and 16β-hydroxy-18-homoethynyloestradiol, are present in amounts smaller than 0.01 % of the dose. Without the reduction steps the percentages are noticeably higher, indicating artifact formation under alkaline conditions. Similar results were obtained with urines from African Green Monkeys (Cercopithecus Aethiops) that had been dosed with 14C-dl-norgestrel. Radiolabelled 18-homoethynyloestradiol and 16β-hydroxy-18-homoethynyloestradiol were isolated from monkey urine and their identity confirmed by gas chromatography-mass spectrometry.

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