Increased risk of low birthweight, infants small for gestational age, and preterm delivery for women with peptic ulcer

2010 ◽  
Vol 202 (2) ◽  
pp. 164.e1-164.e8 ◽  
Author(s):  
Yi-Hua Chen ◽  
Herng-Ching Lin ◽  
Horng-Yuan Lou
Keyword(s):  
Peptic Ulcer ◽  
Preterm Delivery ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Low Birthweight ◽  
Increased Risk

MEASURING THE EFFECTS OF DDT AND DDE ON PRETERM DELIVERY, SMALL-FOR-GESTATIONAL AGE BIRTH AND LOW BIRTHWEIGHT BIRTH

Epidemiology ◽  
2004 ◽  
Vol 15 (4) ◽  
pp. S187
Author(s):  
Lili Farhang ◽  
Rajiv Bhatia ◽  
June Weintraub ◽  
Myrto Petreas ◽  
Brenda Eskenazi
Keyword(s):  
Preterm Delivery ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Low Birthweight

scholarly journals Term complications and subsequent risk of preterm birth: registry based study

BMJ ◽  
2020 ◽  
pp. m1007
Author(s):  
Liv G Kvalvik ◽  
Allen J Wilcox ◽  
Rolv Skjærven ◽  
Truls Østbye ◽  
Quaker E Harmon
Keyword(s):  
Preterm Birth ◽  
Relative Risk ◽  
Preterm Delivery ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Neonatal Death ◽  
Placental Abruption ◽  
Reverse Direction ◽  
Birth Registry ◽  
Increased Risk

AbstractObjectiveTo explore conditions and outcomes of a first delivery at term that might predict later preterm birth.DesignPopulation based, prospective register based study.SettingMedical Birth Registry of Norway, 1999-2015.Participants302 192 women giving birth (live or stillbirth) to a second singleton child between 1999 and 2015.Main outcome measuresMain outcome was the relative risk of preterm delivery (<37 gestational weeks) in the birth after a term first birth with pregnancy complications: pre-eclampsia, placental abruption, stillbirth, neonatal death, and small for gestational age.ResultsWomen with any of the five complications at term showed a substantially increased risk of preterm delivery in the next pregnancy. The absolute risks for preterm delivery in a second pregnancy were 3.1% with none of the five term complications (8202/265 043), 6.1% after term pre-eclampsia (688/11 225), 7.3% after term placental abruption (41/562), 13.1% after term stillbirth (72/551), 10.0% after term neonatal death (22/219), and 6.7% after term small for gestational age (463/6939). The unadjusted relative risk for preterm birth after term pre-eclampsia was 2.0 (95% confidence interval 1.8 to 2.1), after term placental abruption was 2.3 (1.7 to 3.1), after term stillbirth was 4.2 (3.4 to 5.2), after term neonatal death was 3.2 (2.2 to 4.8), and after term small for gestational age was 2.2 (2.0 to 2.4). On average, the risk of preterm birth was increased 2.0-fold (1.9-fold to 2.1-fold) with one term complication in the first pregnancy, and 3.5-fold (2.9-fold to 4.2-fold) with two or more complications. The associations persisted after excluding recurrence of the specific complication in the second pregnancy. These links between term complications and preterm delivery were also seen in the reverse direction: preterm birth in the first pregnancy predicted complications in second pregnancies delivered at term.ConclusionsPre-eclampsia, placental abruption, stillbirth, neonatal death, or small for gestational age experienced in a first term pregnancy are associated with a substantially increased risk of subsequent preterm delivery. Term complications seem to share important underlying causes with preterm delivery that persist from pregnancy to pregnancy, perhaps related to a mother’s predisposition to disorders of placental function.

scholarly journals AB0372 PREGNANCY OUTCOME IN WOMEN WITH SJÖGREN SYNDROME IS OFTEN COMPLICATED BY PLACENTA INSUFFICIENCY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1486.2-1486
Author(s):  
I. Troester ◽  
F. Kollert ◽  
A. Zbinden ◽  
L. Raio ◽  
F. Foerger
Keyword(s):  
Pregnancy Outcome ◽  
Preterm Delivery ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Low Dose ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Live Births ◽  
Dose Aspirin ◽  
Low Dose Aspirin

Background:Chronic inflammatory rheumatic diseases are often associated with a negative effect on pregnancy outcome. Most obstetrical complications are placenta-mediated such as preterm delivery and growths restrictions. In women with Sjögren syndrome, data on placenta- mediated complications are scarce and conflicting (1,2).Objectives:To analyse neonatal outcome in women with Sjögren syndrome with focus on preterm delivery and growth restriction.Methods:We retrospectively analysed 23 pregnancies of 16 patients with Sjögren syndrome that were followed at our centre with regard to pregnancy outcome, medication and disease characteristics. Small for gestational age was defined as birthweight percentile <10th. Preterm delivery was defined as delivery before 37, early term as delivery between 37-39 and term as delivery between 39-42 weeks of gestation.Results:Of 23 pregnancies, one ended in a miscarriage and 22 resulted in live births including one set of twins. Treatment used during pregnancy was hydroxychloroquine (20 pregnancies), prednisone (8), azathioprine (5) and cyclosporine (2). Concomitant treatment with low-dose aspirin was used in 9 pregnancies.Of the 22 live births, 17 were born at early term and 5 at term. There were no preterm deliveries. Median birth weight was 2820g (range 2095-3845g). Nine newborns (40.9%) were small for gestational age (SGA). Maternal treatment during these pregnancies was hydroxychloroquine in all cases and additional low-dose aspirin in three cases. Elevated CRP levels during pregnancy were found in 57% of the cases with SGA outcome. Only one woman with an SGA infant had positive anti-phospholipid antibodies.Regarding delivery mode, most patients had caesarean sections.Conclusion:In our cohort of women with Sjögren syndrome the prevalence of small for gestational age infants was high despite maternal treatment with hydroxychloroquine. Inflammatory markers could help to identify the patients at risk for placental insufficiency, yet prospective studies of larger cohorts are needed.References:[1]Gupta S et al; Sjögren Syndrome and Pregnancy: A literature review. Perm J 2017; 21:16-047[2]De Carolis S et al; The impact of primary Sjögren’s syndrome on pregnancy outcome: Our series and review of the literature. Autoimmun Rev 2014; 13(2):103-7Disclosure of Interests:Isabella Troester: None declared, Florian Kollert Employee of: Novartis, Astrid Zbinden: None declared, Luigi Raio: None declared, Frauke Foerger Grant/research support from: unrestricted grant from UCB, Consultant of: UCB, GSK, Roche, Speakers bureau: UCB, GSK

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