418: Is isolated echogenic bowel an independent risk factor for intrauterine growth restriction and intrauterine fetal demise?

Introduction: We examined placental weight characteristics associated with donor selective intrauterine growth restriction (SIUGR) among patients with twin-twin transfusion syndrome (TTTS) who underwent laser surgery. Materials and Methods: Fresh placental specimens were studied. Pregnancies with higher-order multiples, fetal demise, or disrupted or nonsubmitted placental specimens were excluded. Placental characteristics prospectively collected included total placental weight, individual placental weight, and placental share. Data were compared between pregnancies with SIUGR (TTTS + SIUGR group) and those without SIUGR (TTTS-only group). Results: Of 369 consecutive patients who underwent laser surgery for TTTS, 155 (42%) met inclusion criteria: 91 with TTTS + SIUGR and 64 with TTTS-only. Compared to the TTTS-only group, patients in the TTTS + SIUGR group had a lower total placental weight (608 ± 163 vs. 687 ± 224 g, p = 0.012), with a lower donor individual placental weight (237 ± 91 vs. 291 ± 124 g, p = 0.002), but no apparent difference in the individual placental weight of recipient twins (371 ± 109 vs. 396 ± 133 g, p = 0.211). Donor placental share was smaller in those pregnancies affected by SIUGR (38.7 ± 9.6 vs. 42.3 ± 9.8%, p = 0.029). Discussion: TTTS patients with SIUGR had a lower total placental weight and a lower donor individual placental weight compared to those without SIUGR. These findings suggest that differences in donor individual placental weights for SIUGR gestations may not solely be related to differences in placental share.

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Serum cholesterol acceptor capacity in intrauterine growth restricted fetuses

Journal of Perinatal Medicine ◽

10.1515/jpm-2016-0270 ◽

2017 ◽

Vol 45 (7) ◽

Cited By ~ 5

Author(s):

Ulrich Pecks ◽

Werner Rath ◽

Dirk O. Bauerschlag ◽

Nicolai Maass ◽

Thorsten Orlikowsky ◽

...

Keyword(s):

Risk Factor ◽

Cardiovascular Diseases ◽

Intrauterine Growth Restriction ◽

Cholesterol Efflux ◽

Independent Risk Factor ◽

Cholesterol Transport ◽

Vascular Risk ◽

Transport Mechanisms ◽

Intrauterine Growth ◽

Acceptor Capacity

AbstractAim:Intrauterine growth restriction (IUGR) is an independent risk factor for the development of cardiovascular diseases later in life. The mechanisms whereby slowed intrauterine growth confers vascular risk are not clearly established. In general, a disturbed cholesterol efflux has been linked to atherosclerosis. The capacity of serum to accept cholesterol has been repeatedly evaluated in clinical studies by the use of macrophage-based cholesterol efflux assays and, if disturbed, precedes atherosclerotic diseases years before the clinical diagnosis. We now hypothesized that circulating cholesterol acceptors in IUGR sera specifically interfere with cholesterol transport mechanisms leading to diminished cholesterol efflux.Methods:RAW264.7 cells were used to determine efflux of [Results:Cholesterol efflux was lower in IUGR as compared to controls [controls: mean 7.7% fractional [Conclusions:Reduced cholesterol efflux in IUGR could account for the enhanced risk of developing cardiovascular diseases later in life.

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Asymmetric intrauterine growth restriction is a risk factor for respiratory inhibition after crying in infants

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.3109/14767058.2014.979784 ◽

2014 ◽

Vol 28 (17) ◽

pp. 2121-2125 ◽

Cited By ~ 2

Author(s):

Hideki Minowa ◽

Aya Mima ◽

Yuka Ikeda ◽

Hajime Yasuhara ◽

Reiko Ebisu ◽

...

Keyword(s):

Risk Factor ◽

Intrauterine Growth Restriction ◽

Growth Restriction ◽

Intrauterine Growth ◽

Respiratory Inhibition

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Monochorionic twin pregnancies increases perinatal risk and is a high risk factor of selective intrauterine growth restriction

10.21203/rs.2.12399/v1 ◽

2019 ◽

Author(s):

Jie Chen ◽

Yue Lian Yang

Keyword(s):

Risk Factors ◽

Risk Factor ◽

High Risk ◽

Intrauterine Growth Restriction ◽

Growth Restriction ◽

Prenatal Health ◽

Monochorionic Twin ◽

Intrauterine Growth ◽

High Risk Factor ◽

Twin Pregnancies

Abstract Background Twins pregnancy can cause a lot of disease, especially monochorionic twin pregnancies, the prenatal infant will have many diseases and have high mortality rate. According to analysis and compare of the twin pregnancy, especially pregnant woman and puerpera’s situation and complication and baby’s situation; we hope we can find the reason which causes the fetus growth restrain of monochorionic twin pregnancies. So we can provide some reference for the prenatal health care, complication prevention and prenatal outcome. Methods We divided 489 cases of twin pregnancies into two groups: monochorionic twin and dichorionic twin and compared the clinical features of them. At last, we used the logistic regression analysis method to analyze the risk factors of selective intrauterine growth restriction(sIUGR). Results The incidences of premature rupture of membranes and sIUGR were significant higher in monochorionic twin and twin-twin transfusion syndrome (TTTS) only exists in monochorionic twin. The weight of the newborn babies(both big and small babies)were significant lower in Monochorionic twin. The neonatal transfer rate was significant higher in monochorionic twin. Gestational weeks and weight of newborn babies are the high risk factors of sIUGR. Conclusions The type of chorion has a great influence to the pregnant period and the ending of maternal women. Monochorionic is a high risk factor of the sIUGR, which means that the main cause of sIUGR is from placenta, so it is a kind of “placental origin disease”.

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Weights of Fetal Membranes and Umbilical Cords: Correlation With Placental Pathology

Pediatric and Developmental Pathology ◽

10.1177/1093526619889460 ◽

2019 ◽

Vol 23 (4) ◽

pp. 249-252 ◽

Cited By ~ 1

Author(s):

Lucy X Ma ◽

Daniel Levitan ◽

Rebecca N Baergen

Keyword(s):

Umbilical Cord ◽

Intrauterine Growth Restriction ◽

Maternal Diabetes ◽

Growth Restriction ◽

Placental Weight ◽

Fetal Membranes ◽

Fetal Demise ◽

Intrauterine Growth ◽

The Mean ◽

Umbilical Cords

Introduction Proper placental gross examination requires weighing the placental disc trimmed of fetal membranes and the umbilical cord. However, untrimmed placental weights are often reported, both in cases submitted for consultation and in publications. Thus, determining the contribution of membranes and cords to untrimmed placental weights would be helpful in estimating the true trimmed weight of placentas. We sought to report the average weights of membranes and cord in term placentas and to correlate these weights with common placental pathologies. Methods A total of 500 consecutive placentas delivered between 36 and 42 weeks gestational age were subjected to a modified grossing protocol, in which the weight of the trimmed and untrimmed placentas, fetal membranes, and umbilical cords were recorded. Acute chorioamnionitis, meconium, maternal vascular malperfusion, and fetal vascular malperfusion were included as pathologic correlates. Clinical data such as the presence of fetal hydrops, intrauterine growth restriction, intrauterine fetal demise, and maternal diabetes were also recorded. Results The mean weights of the trimmed placenta, fetal membranes, and umbilical cords were 442 g (180–805 g), 47.2 g (16–108 g), and 37.9 g (9–126 g), respectively. The fetal membranes and umbilical cord weights contributed a mean of 16% to the total untrimmed placental weight. Meconium was associated with heavier fetal membranes. Fetal vascular malperfusion was associated with longer umbilical cord and thus also with heavier umbilical cords. Maternal vascular malperfusion and intrauterine growth restriction were associated with lighter placentas. Discussion The trimmed placental disc weight may be estimated by subtracting 16% (ie, weight of the fetal membranes and umbilical cord) from the untrimmed placental weight, or alternatively by subtracting the mean weight of the membranes and umbilical cord. It is important to consider the effects of meconium, fetal and maternal vascular malperfusion, and intrauterine growth restriction on membrane and cord weights when estimating the trimmed placental disc weight.

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