scholarly journals 582: The effect of race/ethnicity on adverse perinatal outcomes in patients with pregestational diabetes mellitus

2016 ◽  
Vol 214 (1) ◽  
pp. S312-S313
Author(s):  
Tania Esakoff ◽  
Amy Valent ◽  
Aaron B. Caughey
2012 ◽  
Vol 207 (4) ◽  
pp. 322.e1-322.e6 ◽  
Author(s):  
Brian T. Nguyen ◽  
Yvonne W. Cheng ◽  
Jonathan M. Snowden ◽  
Tania F. Esakoff ◽  
Antonio E. Frias ◽  
...  

2018 ◽  
Vol 19 (11) ◽  
pp. 3696 ◽  
Author(s):  
Anna Pleskacova ◽  
Vendula Bartakova ◽  
Katarina Chalasova ◽  
Lukas Pacal ◽  
Katerina Kankova ◽  
...  

Uric acid (UA) levels are associated with many diseases including those related to lifestyle. The aim of this study was to evaluate the influence of clinical and anthropometric parameters on UA and xanthine (X) levels during pregnancy and postpartum in women with physiological pregnancy and pregnancy complicated by gestational diabetes mellitus (GDM), and to evaluate their impact on adverse perinatal outcomes. A total of 143 participants were included. Analyte levels were determined by HPLC with ultraviolet detection (HPLC-UV). Several single-nucleotide polymorphisms (SNPs) in UA transporters were genotyped using commercial assays. UA levels were higher within GDM women with pre-gestational obesity, those in high-risk groups, and those who required insulin during pregnancy. X levels were higher in the GDM group during pregnancy and also postpartum. Positive correlations between UA and X levels with body mass index (BMI) and glycemia levels were found. Gestational age at delivery was negatively correlated with UA and X levels postpartum. Postpartum X levels were significantly higher in women who underwent caesarean sections. Our data support a possible link between increased UA levels and a high-risk GDM subtype. UA levels were higher among women whose glucose tolerance was severely disturbed. Mid-gestational UA and X levels were not linked to adverse perinatal outcomes.


2000 ◽  
Vol 50 ◽  
pp. 428-429
Author(s):  
Jacinto Lang ◽  
Lemay Valdés ◽  
Bertha Rodriguez ◽  
Yolaida Jarrosay ◽  
Antonio Márquez ◽  
...  

2018 ◽  
Vol 20 (6) ◽  
pp. 461-471 ◽  
Author(s):  
Roman V. Kapustin ◽  
Olga N. Arzhanova ◽  
Alena V. Tiselko

Oxidative stress (OS) plays an important role in embryo development, implantation, placentation, fetal development and labour. Diabetes mellitus (DM) is associated with an increase in OS processes. However, the expression of OS biomarkers in pregnant women with DM remains unclear. Based on a literature review, the features of the pro- and anti-oxidant systems of pregnant women with different types of DM have been established. Pregnancy in patients with DM has been shown to be characterised by an activation of OS processes. This leads to an overexpression of free radicals (peroxynitrite), toxic derivatives (malonic dialdehyde, 8-isoprostane) and specific enzymes (asymmetric dimethylarginine, catalase) and a decrease in the synthesis of antioxidants (superoxide dismutase, glutathione peroxidase and uric acid). The modified expression of these biomarkers is observed both in the blood and the placenta of pregnant women. These disorders can cause an unfavourable course of pregnancy, abnormal development of the placenta and development of adverse perinatal outcomes in pregnant women with DM. Nevertheless, given the inconsistency of data obtained, further scientific studies are needed to clarify this issue.


2010 ◽  
Vol 24 (3) ◽  
pp. 422-426 ◽  
Author(s):  
Tania F. Esakoff ◽  
Aaron B. Caughey ◽  
Ingrid Block-Kurbisch ◽  
Maribeth Inturrisi ◽  
Yvonne W. Cheng

Sign in / Sign up

Export Citation Format

Share Document