scholarly journals Umbilical artery Doppler assessment in fetuses with a congenital heart disease

2022 ◽  
Vol 226 (1) ◽  
pp. S247
Author(s):  
Amelie Pham ◽  
Karampreet Kaur ◽  
Laura C. Ha ◽  
Matthew R. Grace ◽  
Lisa C. Zuckerwise
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Umbilical Artery ◽  
Umbilical Artery Doppler

Abstract 11740: Fetal and Neonatal Markers of Neurodevelopmental Outcome in Congenital Heart Disease

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Ismee A Williams ◽  
Howard Andrews ◽  
Michael M Myers ◽  
William Fifer
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Infant Development ◽  
Umbilical Artery ◽  
Neurodevelopmental Outcome ◽  
Abdominal Circumference ◽  
Temporal Region ◽  
Z Score ◽  
The Right

Objectives: Children with congenital heart disease (CHD) are at risk for abnormal neurodevelopment (ND). We evaluated associations between fetal Doppler and biometry measures, neonatal electroencephalogram (EEG) and 18-month ND. Methods: Fetuses with hypoplastic left heart syndrome (HLHS), transposition of the great arteries (TGA), and tetralogy of Fallot (TOF) had middle cerebral (MCA) and umbilical artery (UA) Doppler velocities, as well as biometry such as head (HC) and abdominal circumference (AC), prospectively recorded at 20-25 (F1), 26-32 (F2), and 33-39 (F3) wks gestational age (GA). Pulsatility indices (PI) with GA-derived z-scores and cerebral-to-placental resistance (CPR) ratios were calculated. Neonatal high-density EEG was preformed preoperatively and the Bayley Scales of Infant Development-III were assessed at 18-months. Factor analysis was used to reduce the number of EEG predictors used in regression analysis. Results: Among 56 CHD fetuses (N=19 HLHS, N=16 TGA, N=21 TOF) who underwent preoperative EEG, ND scores are available for 33 to date. Cardiac subtype was highly associated with EEG and was considered in all models. Cognition scores were predicted by CPR< 1 ever (B=-15.7, P=0.002) and HC/AC at F2 (B=-130, P=0.013, R 2 =0.42). Language scores were predicted by UA PI z-score at F1 (B=-9.6, P=0.005, R 2 =0.27). Motor scores were predicted by UA PI z-score at F1 (B=-3.9, P=0.085), HLHS (B=-15, P<0.001), EFW%ile (B=0.374, P=0.007), and delta band right parietal and right temporal log power in active sleep (B=3.9, P=0.045, R 2 =0.61). Conclusion: Lower umbilical artery pulsatility at 20-25 wks GA was associated with higher 18-month Language and Motor scores. A diagnosis of HLHS predicted poorer Motor scores. Increased EEG power in the parietal and temporal region of the right brain predicted higher Motor scores. A larger abdomen relative to head at 26-32 wks was associated with improved cognition while diminished cerebrovascular compared with placental resistance predicted poorer cognition, similar to what has been observed in the growth restricted fetus. Further investigation is needed to confirm these hypothesis-generating findings.

Prenatally diagnosed single umbilical artery: The role and relationship of additional risk factors in the fetus for congenital heart disease

2015 ◽  
Vol 44 (2) ◽  
pp. 113-117 ◽  
Author(s):  
Kai Chen ◽  
Ugochi Akoma ◽  
Andrea Anderson ◽  
Heather Mertz ◽  
Michael D. Quartermain
Keyword(s):  
Risk Factors ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Umbilical Artery ◽  
Single Umbilical Artery ◽  
Additional Risk ◽  
Relationship Of

171: The relationship between single umbilical artery and congenital heart disease

2014 ◽  
Vol 210 (1) ◽  
pp. S97
Author(s):  
Kai Chen ◽  
Ugochi Akoma ◽  
Andrea Anderson ◽  
Heather Mertz ◽  
Michael Quartermain
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Umbilical Artery ◽  
Single Umbilical Artery ◽  
The Relationship

Monozygotic twins discordant for single umbilical artery and congenital heart disease

1998 ◽  
Vol 179 (1) ◽  
pp. 256-257 ◽  
Author(s):  
Daisuke Nakayama ◽  
Hideaki Masuzaki ◽  
Shuichiro Yoshimura ◽  
Shingo Moriyama ◽  
Tadayuki Ishimaru
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Umbilical Artery ◽  
Monozygotic Twins ◽  
Single Umbilical Artery
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