scholarly journals Alteration in the Gene Encoding Protein Tyrosine Phosphatase Nonreceptor Type 6 (PTPN6/SHP1) May Contribute to Neutrophilic Dermatoses

2011 ◽  
Vol 178 (4) ◽  
pp. 1434-1441 ◽  
Author(s):  
Andrew B. Nesterovitch ◽  
Zsuzsa Gyorfy ◽  
Mark D. Hoffman ◽  
Ellen C. Moore ◽  
Nada Elbuluk ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Gene Encoding ◽  
Protein Tyrosine ◽  
Neutrophilic Dermatoses ◽  
Encoding Protein

scholarly journals AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia

Blood ◽  
2011 ◽  
Vol 118 (23) ◽  
pp. 6132-6140 ◽  
Author(s):  
Tasneem Motiwala ◽  
Nicola Zanesi ◽  
Jharna Datta ◽  
Satavisha Roy ◽  
Huban Kutay ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Lymphocytic Leukemia ◽  
Potential Mechanism ◽  
Wild Type ◽  
Truncated Form ◽  
Gene Encoding ◽  
Protein Tyrosine ◽  
Encoding Protein

Abstract We previously demonstrated that the gene encoding PTPROt, the truncated form of protein tyrosine phosphatase receptor type O expressed predominantly in hematopoietic cells, is a candidate tumor suppressor and is down-regulated in chronic lymphocytic leukemia (CLL). Here, we show that PTPROt expression is significantly reduced in CD19+ spleen B cells from Eμ-T cell leukemia 1 (TCL1) transgenic mice relative to the wild-type mice. Strikingly, as much as a 60% decrease in PTPROt expression occurs at 7 weeks independently of promoter methylation. To elucidate the potential mechanism for this early suppression of PTPROt in these mice, we explored the role of activating protein-1 (AP-1) in its expression. We first demonstrate that AP-1 activation by 12-O-tetradecanoylphorbol-13-acetate induces PTPROt expression with concurrent recruitment of c-fos and c-jun to its promoter. The PTPROt promoter is also responsive to over- and underexpression of AP-1, confirming the role of AP-1 in PTPROt expression. Next, we demonstrate that TCL1 can repress the PTPROt promoter by altering c-fos expression and c-jun activation state. Finally, using primary CLL cells we have shown an inverse relationship between TCL1 and PTPROt expression. These findings further substantiate the role of TCL1 in PTPROt suppression and its importance in the pathogenesis of CLL.

The gene encoding protein-tyrosine phosphatase RPTPε (PTPRE) is assigned to human chromosome 10q26

1996 ◽  
Vol 73 (3) ◽  
pp. 168-170 ◽  
Author(s):  
I.G. Melhado ◽  
L.L. Anderson ◽  
A.M.V. Duncan ◽  
F.R. Jirik
Keyword(s):  
Human Chromosome ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Gene Encoding ◽  
Protein Tyrosine ◽  
Encoding Protein

scholarly journals Estrogen-Mediated Suppression of the Gene Encoding Protein Tyrosine Phosphatase PTPRO in Human Breast Cancer: Mechanism and Role in Tamoxifen Sensitivity

2009 ◽  
Vol 23 (2) ◽  
pp. 176-187 ◽  
Author(s):  
Bhuvaneswari Ramaswamy ◽  
Sarmila Majumder ◽  
Satavisha Roy ◽  
Kalpana Ghoshal ◽  
Huban Kutay ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protein Tyrosine Phosphatase ◽  
Human Breast Cancer ◽  
Tyrosine Phosphatase ◽  
Human Breast ◽  
Gene Encoding ◽  
Protein Tyrosine ◽  
Encoding Protein ◽  
Tamoxifen Sensitivity

scholarly journals The Clinical Relevance of the IBD-Associated Variation within the Risk Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 2 in Patients of the Swiss IBD Cohort

Digestion ◽  
2016 ◽  
Vol 93 (3) ◽  
pp. 182-192 ◽  
Author(s):  
Marianne R. Spalinger ◽  
Marius Voegelin ◽  
Luc Biedermann ◽  
Jonas Zeitz ◽  
Jean-Benoit Rossel ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Clinical Relevance ◽  
Gene Locus ◽  
Tyrosine Phosphatase ◽  
Receptor Type ◽  
Protein Tyrosine ◽  
Risk Gene ◽  
Encoding Protein

scholarly journals The Gene Encoding Human Nuclear Protein Tyrosine Phosphatase, PRL-1

1998 ◽  
Vol 273 (27) ◽  
pp. 17286-17295 ◽  
Author(s):  
Yong Peng ◽  
Anna Genin ◽  
Nancy B. Spinner ◽  
Robert H. Diamond ◽  
Rebecca Taub
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Nuclear Protein ◽  
Tyrosine Phosphatase ◽  
Gene Encoding ◽  
Protein Tyrosine

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

Nature ◽  
1992 ◽  
Vol 359 (6396) ◽  
pp. 644-647 ◽  
Author(s):  
Stephen M. Keyse ◽  
Elizabeth A. Emslie
Keyword(s):  
Oxidative Stress ◽  
Heat Shock ◽  
Protein Tyrosine Phosphatase ◽  
Human Gene ◽  
Tyrosine Phosphatase ◽  
Gene Encoding ◽  
Protein Tyrosine

scholarly journals A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis

2004 ◽  
Vol 75 (2) ◽  
pp. 330-337 ◽  
Author(s):  
Ann B. Begovich ◽  
Victoria E.H. Carlton ◽  
Lee A. Honigberg ◽  
Steven J. Schrodi ◽  
Anand P. Chokkalingam ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Single Nucleotide Polymorphism ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Nucleotide Polymorphism ◽  
Gene Encoding ◽  
Single Nucleotide ◽  
Protein Tyrosine
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