Pharmacokinetic changes of tramadol in rats with hepatotoxicity induced by ethanol and acetaminophen in perfused rat liver model

Alcohol ◽  
2019 ◽  
Vol 77 ◽  
pp. 49-57
Author(s):  
Saeid Mohammadi ◽  
Alireza Nezami ◽  
Zohre Esmaeili ◽  
Mohammad Reza Rouini ◽  
Yalda H. Ardakani ◽  
...  
Keyword(s):  
Rat Liver ◽  
Perfused Rat Liver ◽  
Liver Model

Liver Blood Flow as a Major Determinant of the Clearance of Recombinant Human Tissue-Type Plasminogen Activator

1992 ◽  
Vol 67 (01) ◽  
pp. 083-087 ◽  
Author(s):  
A de Boer ◽  
C Kluft ◽  
J M Kroon ◽  
F J Kasper ◽  
H C Schoemaker ◽  
...  
Keyword(s):  
Blood Flow ◽  
Rat Liver ◽  
Healthy Subjects ◽  
Liver Blood Flow ◽  
Major Determinant ◽  
Tissue Type ◽  
Perfused Rat Liver ◽  
Liver Model ◽  
Type Plasminogen Activator ◽  
Proportional Change

SummaryThe influence of changes in liver blood flow on the clearance of rt-PA was studied both in healthy subjects and in a perfused rat liver model. Liver blood flow in healthy subjects was documented indirectly by the clearance of indocyanine green (ICG). Exercise reduced liver blood flow on average by 57% with a 95% confidence interval (95% Cl) ranging from 51% to 62% (n = 5) and increased plasma levels of rt-PA activity (after an i. v. infusion of 18 mg of rt-PA over 120 min) by 119% (95% Cl, 58% - 203%) and rt-PA antigen by 91% (95% Cl, 30% - 140%). In the perfused rat liver model it was shown that halving or doubling of the physiological flow rate of a perfusate, containing rt-PA caused a proportional change in the clearance of rt-PA, while the extraction of rt-PA by the liver remained similar. In conclusion, liver blood flow is a major determinant of the clearance of rt-PA. This may have important implications for dosage of rt-PA in patients with myocardial infarction.

Development of the Isolated Dual Perfused Rat Liver Model as an Improved Reperfusion Model for Transplantation Research

2006 ◽  
Vol 29 (2) ◽  
pp. 219-227 ◽  
Author(s):  
N.A. 'T Hart ◽  
A. Van Der Plaats ◽  
C. Moers ◽  
H.G.D. Leuvenink ◽  
J. Wiersema-Buist ◽  
...  
Keyword(s):  
Rat Liver ◽  
Perfused Rat Liver ◽  
Liver Model

Effect of aging on liver functions—an experimental study in a perfused rat liver model

2004 ◽  
Vol 39 (9) ◽  
pp. 1341-1346 ◽  
Author(s):  
Marion Jourdan ◽  
Michel Vaubourdolle ◽  
Luc Cynober ◽  
Christian Aussel
Keyword(s):  
Experimental Study ◽  
Rat Liver ◽  
Perfused Rat Liver ◽  
Liver Model ◽  
Liver Functions

The Interaction between Cyclosporin A and Erythromycin Studied by Means of an Isolated Perfused Rat Liver Model

1989 ◽  
Vol 65 (3) ◽  
pp. 198-203 ◽  
Author(s):  
Isabelle Fabre ◽  
Bruno Richard ◽  
Jean Combalbert ◽  
Gérard Fabre ◽  
Jean-Paul Cano
Keyword(s):  
Cyclosporin A ◽  
Rat Liver ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver ◽  
Liver Model

Use of isolated perfused rat liver model for testing liver preservation solutions

2001 ◽  
Vol 33 (7-8) ◽  
pp. 3709-3711 ◽  
Author(s):  
I Ahmed ◽  
M.S Attia ◽  
N Ahmad ◽  
J.P.A Lodge ◽  
D.J Potts
Keyword(s):  
Rat Liver ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver ◽  
Liver Preservation ◽  
Liver Model ◽  
Preservation Solutions
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