TCT-194: Efficiency of Intramyocardial Injections of Aautologous Bone Marrow Mononuclear Stem Cells in Patients with Ischemic Heart Failure: Long-term Results

2009 ◽  
Vol 104 (6) ◽  
pp. 74D-75D
2009 ◽  
Vol 15 (6) ◽  
pp. S44
Author(s):  
Evgeniy Pokushalov ◽  
Alexander Romanov ◽  
Sergey Artemenko ◽  
Olga Poveschenko ◽  
Alexander Cherniavskiy

Author(s):  
Jan Naar ◽  
Ivo Skalský ◽  
Andreas Krűger ◽  
Filip Málek ◽  
Kevin Van Bladel ◽  
...  

AbstractThe evidence supporting surgical aneurysmectomy in ischemic heart failure is inconsistent. The aim of the study was to describe long-term effect of minimally invasive hybrid transcatheter and minithoracotomy left ventricular (LV) reconstruction in patients with ischemic cardiomyopathy. Twenty-three subjects with transmural anterior wall scarring, LV ejection fraction 15–45%, and New York Heart Association class ≥ II were intervened using Revivent TC anchoring system. LV end-systolic volume index was reduced from 73.2 ± 27 ml at baseline to 51.5 ± 22 ml after 6 months (p < 0.001), 49.9 ± 20 ml after 2 years (p < 0.001), and 56.1 ± 16 ml after 5 years (p = 0.047). NYHA class improved significantly at 5 years compared to baseline. Six-min walk test distance increased at 2 years compared to the 6-month visit. Hybrid LV reconstruction using the anchoring system provides significant and durable LV volume reduction during 5-year follow-up in preselected patients with ischemic heart failure. Graphical abstract


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