Relation of Severe Deficiency of Vitamin D to Cardiovascular Mortality During Acute Coronary Syndromes

The aim of this observational study was to evaluate the impact of myocardial revascularization performed after acute coronary syndromes on one-year cardiovascular mortality. Material and Methods. The study population comprised 1226 consecutive patients who were admitted to the Clinic of Cardiology in 2005 because of acute coronary syndromes with significant (≥70%) coronary artery stenoses. The relationship between myocardial revascularization and oneyear cardiovascular mortality was evaluated by applying multivariable logistic regression. Cardiovascular mortality was evaluated using the Kaplan-Meier method. Results. Of all the patients included into the study, 540 had Q-wave myocardial infarction, 339 patients had non–Q-wave myocardial infarction, and 347 patients were treated for unstable angina pectoris. During hospitalization, 496 patients underwent percutaneous transluminal coronary angioplasty, 373 patients underwent coronary artery bypass grafting within 60 days following acute coronary syndromes, and 357 patients received pharmacological treatment alone. During one-year follow-up, 105 cases of cardiovascular death were registered. The one-year cardiovascular mortality was significantly lower in patients who underwent percutaneous transluminal coronary angioplasty or coronary artery bypass grafting comparing with those patients who received only pharmacotherapy (5.4% and 7.8% vs. 14.3%, P<0.05). Multivariate logistic regression analysis revealed that myocardial revascularization independently reduced one-year cardiovascular mortality (adjusted odds ratio for percutaneous transluminal coronary angioplasty, 0.304; 95% CI, 0.18 to 0.53; P<0.001, and coronary artery bypass grafting, 0.540; 95% CI, 0.32 to 0.90; P=0.018) in patients who were admitted because of acute coronary syndromes. Conclusions. Myocardial revascularization performed after acute coronary syndromes was significantly associated with the reduction of cardiovascular mortality within one-year period independently of clinical variables.

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Atorvastatin increase vitamin D levels in patients with acute coronary syndromes

Inpharma Weekly ◽

10.2165/00128413-200715870-00050 ◽

2007 ◽

Vol &NA; (1587) ◽

pp. 20

Author(s):

&NA;

Keyword(s):

Vitamin D ◽

Acute Coronary Syndromes ◽

Vitamin D Levels ◽

Coronary Syndromes

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Osteoprotegerin and cardiovascular mortality in patients with non-ST elevation acute coronary syndromes

Heart ◽

10.1136/heartjnl-2011-301260 ◽

2012 ◽

Vol 98 (10) ◽

pp. 786-791 ◽

Cited By ~ 24

Author(s):

Ragnhild Røysland ◽

Marc P Bonaca ◽

Torbjørn Omland ◽

Marc Sabatine ◽

Sabina A Murphy ◽

...

Keyword(s):

Cardiovascular Mortality ◽

Acute Coronary Syndromes ◽

Coronary Syndromes ◽

St Elevation

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Determinants of vitamin D activation in patients with acute coronary syndromes and its correlation with inflammatory markers

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/j.numecd.2020.09.021 ◽

2020 ◽

Author(s):

Arraa M. Saghir Afifeh ◽

Monica Verdoia ◽

Matteo Nardin ◽

Federica Negro ◽

Filippo Viglione ◽

...

Keyword(s):

Vitamin D ◽

Inflammatory Markers ◽

Acute Coronary Syndromes ◽

Coronary Syndromes

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Determinants of plasma vitamin D levels in patients with acute coronary syndromes

European Journal of Clinical Investigation ◽

10.1111/j.1365-2362.2011.02540.x ◽

2011 ◽

Vol 41 (12) ◽

pp. 1299-1309 ◽

Cited By ~ 5

Author(s):

Gabriella Rodriguez ◽

Aijing Z. Starr ◽

Grazyna Z. Czernuszewicz ◽

Amit Manhas ◽

Ahmad Alhariri ◽

...

Keyword(s):

Vitamin D ◽

Acute Coronary Syndromes ◽

Plasma Vitamin ◽

Vitamin D Levels ◽

Coronary Syndromes

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Excess of cardiovascular deaths during the COVID-19 pandemic in Brazilian capital cities

Heart ◽

10.1136/heartjnl-2020-317663 ◽

2020 ◽

Vol 106 (24) ◽

pp. 1898-1905 ◽

Cited By ~ 2

Author(s):

Luisa Campos Caldeira Brant ◽

Bruno Ramos Nascimento ◽

Renato Azeredo Teixeira ◽

Marcelo Antônio Cartaxo Queiroga Lopes ◽

Deborah Carvalho Malta ◽

...

Keyword(s):

Cardiovascular Mortality ◽

Acute Coronary Syndromes ◽

Cardiovascular Events ◽

Rio De Janeiro ◽

Excess Mortality ◽

Strongly Correlated ◽

Public Database ◽

Capital Cities ◽

Coronary Syndromes ◽

Excess Deaths

IntroductionDuring the COVID-19 pandemic, excess mortality has been reported, while hospitalisations for acute cardiovascular events reduced. Brazil is the second country with more deaths due to COVID-19. We aimed to evaluate excess cardiovascular mortality during COVID-19 pandemic in 6 Brazilian capital cities.MethodsUsing the Civil Registry public database, we evaluated total and cardiovascular excess deaths, further stratified in specified cardiovascular deaths (acute coronary syndromes and stroke) and unspecified cardiovascular deaths in the 6 Brazilian cities with greater number of COVID-19 deaths (São Paulo, Rio de Janeiro, Fortaleza, Recife, Belém, Manaus). We compared observed with expected deaths from epidemiological weeks 12–22 of 2020. We also compared the number of hospital and home deaths during the period.ResultsThere were 65 449 deaths and 17 877 COVID-19 deaths in the studied period and cities for 2020. Cardiovascular mortality increased in most cities, with greater magnitude in the Northern capitals. However, while there was a reduction in specified cardiovascular deaths in the most cities, the Northern capitals showed an increase of these events. For unspecified cardiovascular deaths, there was a marked increase in all cities, which strongly correlated to the rise in home deaths (r=0.86, p=0.01).ConclusionExcess cardiovascular mortality was greater in the less developed cities, possibly associated with healthcare collapse. Specified cardiovascular deaths decreased in the most developed cities, in parallel with an increase in unspecified cardiovascular and home deaths, presumably as a result of misdiagnosis. Conversely, specified cardiovascular deaths increased in cities with a healthcare collapse.

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