Relation of Physical Activity to Prevalence of Nonalcoholic Fatty Liver Disease Independent of Cardiometabolic Risk

The aim of the current study was to examine the independent association of physical activity with nonalcoholic fatty liver disease (NAFLD) and aminotransferases while adjusting for obesity and diet. Cross-sectional data from 32,391 participants aged ≥ 20 years in the Korea National Health and Nutrition Examination Surveys (KNHANES) was analyzed by logistic regression models and general linear models. Physical activity was assessed from the questionnaire by health-enhancing physical activity (HEPA). The physical activity was negatively associated with NAFLD and lean NAFLD after adjustment for multiple factors with an odds ratio of 0.7 (95% CI, 0.6–0.8) and 0.5 (95% CI, 0.4–0.7) comparing the most active (HEPA active) and the least active (inactive) participants. Among the participants with NAFLD, physical activity also showed an independent negative association with alanine aminotransferase (ALT) levels but not with aspartate aminotransferase levels. These independent associations were not observed when comparing the minimally active and inactive participants except for the risk of lean NAFLD. Physical activity is independently associated with the degree of hepatocellular injury in patients with NAFLD as well as the risk of NAFLD and lean NAFLD in the general population. Sufficiently active physical activity greater than a minimally active level may be needed to lower the risk of NAFLD and ALT levels.

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Fatty liver and global cardiometabolic risk

Orvosi Hetilap ◽

10.1556/oh.2010.29003 ◽

2010 ◽

Vol 151 (47) ◽

pp. 1946-1950 ◽

Cited By ~ 4

Author(s):

Lajos Szollár

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Nonalcoholic Steatohepatitis ◽

Fatty Liver Disease ◽

Cardiometabolic Risk ◽

Nonalcoholic Fatty Liver

A nem alkoholos zsírmáj betegség (NAFLD = nonalcoholic fatty liver disease) az „iparilag fejlett” országok felnőtt lakosságának 30%-ában észlelhető. Előrehaladott, súlyosabb formája a nem alkoholos steatohepatitis (NASH = nonalcoholic steatohepatitis), amelyből az esetek 20%-ában cirrhosis alakul ki, a kialakult cirrhosis mintegy 30–40%-a májeredetű halálhoz, elsősorban hepatocellularis carcinomához vezethet. Az NAFLD-t sokan a metabolikus szindróma májbeli manifesztációjának tartják, e két jelenség kapcsolatát tekintjük át, különös tekintettel a hasi elhízás, az inzulinrezisztencia, az oxidatív stressz és a csökkent antioxidáns védelem kóroki szerepére. A májsejtek trigliceridtartalmának növekedése együtt jár az egész szervezet, illetve a máj inzulinrezisztenciájával. Klasszikus tyúk–tojás probléma: a lipidlerakódás oka az inzulinrezisztencia, vagy az inzulinrezisztencia az ectopiás lipidfelhalmozódás következménye? A patogenetikai történések egy lehetséges sorrendje: megnövekedett zsírsavfluxus, a májbeli zsírsavkínálat növekedése → VLDL-túltermelődés, atherogen dyslipidaemia → a zsírsavak fokozott oxidációja és peroxidációja, enormis szabadgyök-terhelés → az antioxidáns védekezőrendszer kimerülése → a gyulladást és az immunválaszt kiváltó mediátorok „cunamiszerű” kiáramlása → a fibrosis progresszióját elősegítő transzkripciós és transzlációs változások → carcinogenesis. Az NAFLD és a metabolikus szindróma egyaránt része a globális kardiometabolikus kockázatnak, így lényeges a korai felismerés, és – amennyiben lehetséges a kezelés – ez ma a metabolikus szindróma részelemeinek kezelési ajánlásaiban testesül meg. Orv. Hetil., 2010, 47, 1946–1950.

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Physical Activity Is Prospectively Associated With Adolescent Nonalcoholic Fatty Liver Disease

Journal of Pediatric Gastroenterology and Nutrition ◽

10.1097/mpg.0000000000000904 ◽

2016 ◽

Vol 62 (1) ◽

pp. 110-117 ◽

Cited By ~ 3

Author(s):

Emma L. Anderson ◽

Abigail Fraser ◽

Laura D. Howe ◽

Mark P. Callaway ◽

Naveed Sattar ◽

...

Keyword(s):

Physical Activity ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Nonalcoholic Fatty Liver

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Objectively Measured Physical Activity Is Inversely Associated With Nonalcoholic Fatty Liver Disease: The Rotterdam Study

The American Journal of Gastroenterology ◽

10.14309/ajg.0000000000001584 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Laurens A. van Kleef ◽

Amy Hofman ◽

Trudy Voortman ◽

Robert J. de Knegt

Keyword(s):

Physical Activity ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Rotterdam Study ◽

Nonalcoholic Fatty Liver ◽

Objectively Measured ◽

Objectively Measured Physical Activity

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Noninvasive Markers of Improvement of Liver Steatosis Achieved by Weight Reduction in Patients with Nonalcoholic Fatty Liver Disease

Romanian Journal Of Internal Medicine ◽

10.1515/rjim-2015-0008 ◽

2015 ◽

Vol 53 (1) ◽

pp. 56-64 ◽

Cited By ~ 1

Author(s):

Ionel Copaci ◽

Ioana Lupescu ◽

Elena Caceaune ◽

Grethi Chiriac ◽

G. Ismail

Keyword(s):

Physical Activity ◽

Liver Disease ◽

Waist Circumference ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Weight Reduction ◽

Fatty Liver Disease ◽

Liver Steatosis ◽

Moderate Intensity ◽

Nonalcoholic Fatty Liver

Abstract Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance and metabolic syndrome, which are linked to obesity. The aim of the study was to assess if weight reduction through 12 months of lifestyle intervention and exercise would lead to improvement of steatosis. Methods. In a prospective observational study 86 overweight subjects (51 men, 35 women) with steatosis were recruited, after excluding other etiologies. Patients were assigned a caloric goal and a daily fat goal. Physical activity focused on moderate-intensity activities. Blood samples (biochemistry, HOMA-IR, cytokine levels, steatotest) were collected at entry and months 6 and 12. All subjects underwent abdominal CT scan before commencement and after 12 months to assess visceral and subcutaneous adipose tissue (VAT/SAT) area. Results. After 12 months baseline descriptive characteristics (weight, BMI, waist circumference) decreased significantly. Biochemical parameters that decreased significantly were: GGT (40.0 ± 18.0 vs 31.1 ± 13; p = 0.01), ALT (58.5 ± 23.5 vs 32,7 ± 14.8; p = 0.001), cholesterol (236.4 ± 54.8 vs 204.8 ± 91; p = 0.05), LDL (160.1 ± 47.4 vs 125.3 ± 40; p = 0.05) and HOMA-R (4.86 ± 0.63 vs 3 ± 0.41; p = 0.018). Steatotest improved significantly (0.68 ± 0.16 vs 0.38 ± 0.14; p = 0.02). Modification of adipocytokines was significant for leptin (p = 0.018) and adiponectin (p = 0.003). Factors associated with regression of steatosis were weight, BMI, ALT, waist circumference, GGT, HOMA, leptin, VAT and steatotest. Multivariate logistic regression showed the following factors related to improved steatosis: BMI < 25 kg/m2, ALT < 42 U/L, leptin < 10.5 ng/ml and adiponectin > 8.4 μg/ml. Conclusions. Overweight persons who achieve significant reductions in body weight through 12 months of physical activity and low caloric diet can decrease liver fat, VAT and SAT. Even in those with minimal weight loss ALT levels, steatosis, adipokines and cardiovascular risk factors improved.

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