Effect of topical pramoxine hydrochloride on discomfort, wheal and flare associated with epicutaneous allergy test

2019 ◽  
Vol 122 (6) ◽  
pp. 652-653
Author(s):  
Erika T. Watts-Oquendo ◽  
Giannina Coppola-Fasick ◽  
Erving Arroyo-Flores ◽  
Marievelisse Soto-Salgado ◽  
Sylvette Nazario
Keyword(s):  
ORL ◽  
2021 ◽  
pp. 1-7
Author(s):  
Ho Yun Lee ◽  
Jung-Soo Pyo ◽  
Su Jin Kim

<b><i>Introduction:</i></b> Tissue remodeling refers to structural changes that occur in damaged tissue and is associated with disease severity in asthma. However, the characteristics of tissue remodeling and its prognostic role in chronic rhinosinusitis (CRS) remain unclear. In this report, we evaluated the clinical implications of tissue remodeling in CRS. <b><i>Methods:</i></b> We performed a retrospective cohort study of adult patients who underwent endoscopic sinus surgery for bilateral CRS. The histopathology of sinus mucosa was determined by evaluating the inflammatory cell count and tissue remodeling markers (squamous metaplasia, subepithelial gland proliferation, basement membrane [BM] thickening, stromal edema, and fibrosis). Eosinophilic CRS (ECRS) was defined as an eosinophil count &#x3e;15/high-power field in the biopsied tissue. Patient characteristics, allergy test grade, preoperative Lund-Mackay score (LMS), and pre- and postoperative Lund-Kennedy scores (LKSs) were analyzed. <b><i>Results:</i></b> Of the identified patients, 59.1% were classified as ECRS and the remaining 40.9% as non-ECRS. Regarding tissue remodeling markers, stromal edema was seen in 90.9%, BM thickening in 63.6%, and stromal fibrosis in 34.1% of patients. In cases with stromal edema and BM thickening, greater tissue eosinophilia was observed, while stromal fibrosis decreased tissue eosinophilia (<i>p</i> &#x3c; 0.05). Prognostically, subepithelial gland proliferation alone was an independent risk factor for poor postoperative endoscopic findings (odds ratio: 8.250, 95% confidence interval: 1.128–60.319, <i>p</i> = 0.038). <b><i>Conclusions:</i></b> Tissue eosinophilia was commonly associated with BM thickening and stromal edema. Subepithelial gland proliferation predicted a poor surgical prognosis in CRS. These findings imply that tissue remodeling provides additional information not only on the CRS endotype but also on the postsurgical prognosis.


Allergy ◽  
2000 ◽  
Vol 55 (4) ◽  
pp. 382-385 ◽  
Author(s):  
R. Fadel ◽  
I. Ramboer ◽  
N. Chatterjee ◽  
J.-P. Rihoux ◽  
M.-P. Derde

2000 ◽  
Vol 4 (2) ◽  
pp. 89-93 ◽  
Author(s):  
Jasdeep K. Sharma ◽  
Robert Miller ◽  
Scott Murray

Background: Chronic urticaria is a common condition and is a source of great frustration to patients. It has been suggested that there may be differences among physicians in their approach to this common clinical entity. Objective and Method: A questionnaire was distributed Canada-wide to allergists, dermatologists, and a selection of practitioners with an interest in alternative medicine. The survey included questions on demographics, epidemiology, causative factors, diagnostic methods, therapeutic strategies, follow-up advice, and efficacy of therapies, with emphasis on personal experience. Results: The response rates of allergists and dermatologists were 31% and 36%, respectively. There was wide representation from all regions of Canada and from physicians from all age groups, both genders, different types of practice, and years in practice. The reported incidence per month was 13 and 4 patients for allergists and dermatologists, respectively. The prevalence was 199 and 44 patients by allergists and dermatologists, respectively. Comparison of causative factors showed differences in the experiences of the two groups. Diagnostic investigations were requested in a similar pattern with respect to timing. The specific tests ordered by the groups showing statistical difference were complete blood count (CBC), differential, C4 complement, antinuclear antibodies, and IgE antibody assay. Allergists chose the skin prick test (100%) as the most important allergy test. Dermatologists ranked skin prick (50%), radioallergosorbent test (RAST) (20%), and skin patch (30%) as the most important tests. The top six choices of pharmaceutical therapies chosen by the groups were similar, but in a slightly different order. The responders ranked their personal selection of antihistamines according to effectiveness. Hydroxyzine (Atarax®) and cetirizine (Reactine®, Allegra®) were selected as first and second most effective agents by both groups. The results also show effective experience by both groups with nonsedating and sedating antihistamines. Also, doxepin, ketotifen, and cimetidine are used frequently by both groups. The experience of dermatologists in Canada with respect to other modalities including psoralen ultraviolet A (PUVA) therapy, danazol, chelation, calcium channel blockers, and acyclovir is limited and efficacy is ranked either neutral or ineffective. Allergists reported even less experience with these therapies. Conclusion: Allergists and dermatologists across Canada show interesting similarities and differences in their practical approach to the management of chronic urticaria. With the sharing of this information, these two specialties will be better equipped to effectively manage patients suffering from chronic urticaria.


Allergy ◽  
2000 ◽  
Vol 55 (9) ◽  
pp. 888-891 ◽  
Author(s):  
R. Fadel ◽  
I. Ramboer ◽  
N. Chatterjee ◽  
J-P. Rihoux ◽  
M-P. Derde

2003 ◽  
Vol 91 (1) ◽  
pp. 26-33 ◽  
Author(s):  
P Brock Williams ◽  
Staffan Ahlstedt ◽  
James H. Barnes ◽  
Lars Söderström ◽  
Jay Portnoy
Keyword(s):  

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Anna Piotrowska ◽  
Magdalena Zając ◽  
Łukasz Tota ◽  
Olga Czerwińska ◽  
Natalia Totko-Borkusiewicz ◽  
...  

Introduction. Pollen is a plant-based product and is a rich source of biologically active compounds such as: proteins, amino acids, carbohydrates, fats and fatty acids, phenolic compounds and enzymes, considered as an promising ingredient in cosmetic formulations. Aim. The aim of this study was to analyze the effect of a cream enriched with micronized bee pollen on selected skin characteristics evaluated in subjective and objective manner. Material and methods. The participants were 13 female volunteers (students) who met the following criteria: no dermatological and endocrine diseases, non-smoking and no special or elimination diets up to 3 months before the study, and also a negative allergy test result. Students were randomly assigned to the following groups: the experimental group – subjects using cream with 3% micronized bee pollen and the control one using cream base. Before and after the 5-day treatment, the participants undewent the measurements of skin hydration. The subjective evaluation of selected skin properties was examined by using a 3-grade scale. Results. All skin characteristics evaluated subjectively improved as a result of pollen-enriched formula treatment. The participants of the experimental group have noticed a significant change in the following properties: moisturizing, smoothness and skin tightening. The final measurement of skin hydration has showed an increase of 12.14 units in the experimental group and 4.52 units in the control group, indicating difference between groups (p = 0.0389). Also a positive correlation between application time and moisturizing (R = 0.929) has been found. Conclusions. The micronized bee pollen, as an active ingredient in protective and moisturizing preparations, seems to be an effective ingredient.


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