Pediatric type 1 cartilage tympanoplasty outcomes: A comparison of short and long term hearing results

Aim: Our aim was to investigate the characteristics, treatment and prognosis of patients with myocardial infarction (MI) treated outside a cardiology department (CD), compared with MI patients treated at a CD. Methods: A cohort of 1310 patients diagnosed with MI at eight Swedish hospitals in 2011 were included in this observational study. Patients were followed regarding all-cause mortality until 2018. Results: A total of 235 patients, exclusively treated outside CDs, were identified. These patients had more non-cardiac comorbidities, were older (mean age 83.7 vs. 73.1 years) and had less often type 1 MIs (33.2% vs. 74.2%), in comparison with the CD patients. Advanced age and an absence of chest pain were the strongest predictors of non-CD care. Only 3.8% of non-CD patients were investigated with coronary angiography and they were also prescribed secondary preventive pharmacological treatments to a lesser degree, with only 32.3% having statin therapy at discharge. The all-cause mortality was higher in non-CD patients, also after adjustment for baseline parameters, both at 30 days (hazard ratio (HR) 2.28; 95% confidence interval (CI) 1.62–3.22), one year (HR 1.82; 95% CI 1.39–2.36) and five years (HR 1.62; 95% CI 1.32–1.98). Conclusions: MI treatment outside CDs is associated with an adverse short- and long-term prognosis. An improved use of percutaneous coronary intervention (PCI) and secondary preventive pharmacological treatment might improve the long-term prognosis in these patients.

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Long-Term Experience with Biocompatible Ossicular Implants

Otolaryngology ◽

10.1177/019459988609400614 ◽

1986 ◽

Vol 94 (6) ◽

pp. 611-616 ◽

Cited By ~ 8

Author(s):

John R. Emmett ◽

John J. Shea ◽

William H. Moretz

Keyword(s):

Chronic Otitis Media ◽

Hearing Results ◽

Common Causes ◽

Ossicular Replacement ◽

Stapes Prosthesis ◽

Short And Long Term ◽

Conductive Hearing ◽

Long Term Experience

The senior author's 8-year personal experience with biocompatible ossicular implants is reviewed. Four hundred sixty-one consecutive operations, in which high-density polyethylene sponge ossicular replacement prostheses were used, are grouped according to the Bellucci classification of chronic otitis media. The prostheses used were the drum-to-footplate prosthesis (TORP, total) and the drum-to-stapes prosthesis (PORP, partial)*. Each group's short- and long-term hearing results are compared. Prosthesis extrusion and persistent or recurrent conductive hearing loss are the most common causes of operation failure. Failures within each group are analyzed, and techniques to prevent these complications are outlined.

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Bariatric surgery in patients with type 1 diabetes: special considerations are warranted

Therapeutic Advances in Endocrinology and Metabolism ◽

10.1177/2042018818822207 ◽

2019 ◽

Vol 10 ◽

pp. 204201881882220 ◽

Cited By ~ 5

Author(s):

Zohar Landau ◽

Galit Kowen-Sandbank ◽

Daniela Jakubowicz ◽

Asnat Raziel ◽

Nasser Sakran ◽

...

Keyword(s):

Bariatric Surgery ◽

Type 1 Diabetes ◽

Diabetic Ketoacidosis ◽

Glucose Control ◽

Healthcare Services ◽

Short And Long Term ◽

The Mean

Objective: We examined short and long-term outcomes of bariatric surgery in patients with obesity and type 1 diabetes mellitus (T1DM). Methods: We reviewed the records of all adults insured by Maccabi Healthcare Services during 2010 -2015, with body mass index (BMI) ⩾30 kg/m2 and T1DM; and compared weight reduction and glucose control according to the performance of bariatric surgery. BMI and glycated hemoglobin (HbA1c) levels were extracted for baseline and every 6 months, for a mean 3.5 years. Results: Of 52 patients, 26(50%) underwent bariatric surgery. Those who underwent surgery were more often female and with a longer duration of diabetes. Immediately postoperative, 4(15%) developed diabetic ketoacidosis, while 6(23%) experienced severe hypoglycemic episodes. The mean BMI decreased among surgery patients: from 39.5±4.4 to 30.1±5.0 kg/m2 ( p < 0.0001); and increased among those who did not undergo surgery: from 33.6±3.9 to 35.1±4.4 kg/m2 ( p = 0.49). The mean HbA1c level decreased during the first 6 months postoperative: from 8.5±0.9% to 7.9±0.9%; however, at the end of follow-up, was similar to baseline, 8.6±2.0% (p = 0.87). For patients who did not undergo surgery, the mean HbA1c increased from 7.9±1.9% to 8.6±1.5% ( p = 0.09). Conclusions: Among individuals with obesity and T1DM, weight loss was successful after bariatric surgery, but glucose control did not improve. The postoperative risks of diabetic ketoacidosis and severe hypoglycemic episodes should be considering when performing bariatric surgery in this population.

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Signaling of short- and long-term regulation of intestinal epithelial type 1 Na+ /H+ exchanger by interferon-γ

British Journal of Pharmacology ◽

10.1038/sj.bjp.0706167 ◽

2005 ◽

Vol 145 (1) ◽

pp. 93-103 ◽

Cited By ~ 18

Author(s):

Fernando Magro ◽

Sónia Fraga ◽

Patrício Soares-da-Silva

Keyword(s):

Interferon Γ ◽

Intestinal Epithelial ◽

Short And Long Term

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Pediatric Type 1 Cartilage Tympanoplasty: Comparison between Graft Success Rates and Hearing Results in Adults

The Journal of International Advanced Otology ◽

10.5152/iao.2016.2205 ◽

2016 ◽

Vol 12 (3) ◽

pp. 257-260 ◽

Cited By ~ 3

Author(s):

Gultekin Ovet ◽

Necat Alatas ◽

Mehmet Senturk ◽

Fatih Guzelkara

Keyword(s):

Success Rates ◽

Hearing Results ◽

Cartilage Tympanoplasty ◽

Graft Success

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A Single Injection of Pregabalin Induces Short- and Long-Term Beneficial Effects on Fear Memory and Anxiety-Like Behavior in Rats with Experimental Type-1 Diabetes Mellitus.

10.21203/rs.3.rs-1053770/v1 ◽

2021 ◽

Author(s):

Alvaro Henrique Bernardo de Lima Silva ◽

Debora Rasec Radulski ◽

Gabriela Pereira ◽

Alexandra Acco ◽

Janaína Menezes Zanoveli

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Single Injection ◽

Fear Memory ◽

Fear Extinction ◽

Short And Long Term ◽

Extinction Memory

Abstract Anxiety Disorders and Posttraumatic Stress Disorders (PTSD) associated with type 1 diabetes mellitus (DM1) are increasingly common comorbidities and the treatment is quite challenging. In that sense, evidence indicates that the anticonvulsant pregabalin is highly effective in treating severe cases of anxiety, as well as PTSD and diabetic neuropathic pain which is also very prevalent in T1DM. Herein, the short- and long-term effects of a single injection of pregabalin on the acquisition of a fear extinction memory and parameters of anxiety in induced-T1DM animals were investigated. For that, we used the contextual fear conditioning (CFC) and elevated plus maze (EPM) paradigms, respectively. A putative antioxidant activity was also evaluated. Our findings demonstrated that induced-T1DM animals presented greater expression of fear memory, difficulty in extinguishing this fear memory, associated with a more pronounced anxiety-like response. Pregabalin was able to induce a short and long-lasting effect by facilitating the acquisition of the fear extinction memory and inducing a later anxiolytic-like effect. Also, the increased lipid peroxidation levels in the hippocampus and prefrontal cortex of induced-T1DM rats were reduced after pregabalin injection, while the decreased levels of reduced glutathione were increased in the hippocampus. Despite the need for more studies to understand the mechanism of action of pregabalin under these conditions, our data demonstrate for the first time that a single injection of pregabalin in a specific time window was able to improve behavioral parameters in addition to inducing neuroprotective effect. Thus, pregabalin has potential worth exploring for the treatment of PTSD and/or Anxiety associated with T1DM.

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