scholarly journals P56-7 A case of Nuclear protein in testis (NUT) midline carcinoma with response to Ewing sarcoma-based chemotherapy regimen

2021 ◽  
Vol 32 ◽  
pp. S360
Author(s):  
Yuki Nakatani ◽  
Yuko Akaisi ◽  
Furutama Junko ◽  
Asuka Okada ◽  
Kohei Akiyoshi ◽  
...  
Keyword(s):  
Ewing Sarcoma ◽  
Nuclear Protein ◽  
Chemotherapy Regimen ◽  
Nut Midline Carcinoma

scholarly journals Cytological Features of a Variant NUT Midline Carcinoma of the Lung Harboring theNSD3-NUTFusion Gene: A Case Report and Literature Review

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Shiho Kuroda ◽  
Shioto Suzuki ◽  
Akira Kurita ◽  
Mari Muraki ◽  
Yoichiro Aoshima ◽  
...  
Keyword(s):  
Case Report ◽  
Nuclear Protein ◽  
Lung Tumor ◽  
Nut Midline Carcinoma ◽  
Case Presentation ◽  
First Case ◽  
Cytological Features ◽  
Pearl Formation ◽  
Mitotic Figures ◽  
First Time

Background. Nuclear protein in testis (NUT) midline carcinoma (NMC) is a very rare and aggressive malignancy. In more than two-thirds of these NMC cases, a fusion betweenNUTandBRD4orBRD3has been documented; other variants are rare. The cytology of NMC itself has been sparsely documented and that of variant NMC has never been reported.Case Presentation. A 36-year-old woman was admitted because of a rapidly progressing lung tumor with metastases to the breast and bone. We recently reported this patient as the first case of a variant NMC of the lung harboring anNSD3-NUTfusion, based on immunohistochemical and genetic analyses. Cytological material was available for the present review. A highly cellular smear contained a predominantly noncohesive pattern of monomorphic cells with diameters 2–2.5 times greater than those of small lymphocytes, with a round-to-oval nucleus, slightly irregular nuclear contours, variably prominent nucleoli, scant cytoplasm, and identifiable mitotic figures. Foci of stratification and overt pearl formation, including a dyskeratocyte, were occasionally observed. The necrotic background contained naked nuclei, karyorrhectic debris, apoptotic cells, and macrophages phagocytizing karyorrhectic debris; nuclear crushing was noted.Conclusion. The cytological features of a variant NMC of the lung are described for the first time.

Nuclear protein in testis (NUT) midline carcinoma with a novel three-way translocation (4;15;19)(q13;q14;p13.1)

Pathology ◽  
2016 ◽  
Vol 48 (6) ◽  
pp. 620-623 ◽  
Author(s):  
Seerin Shatavi ◽  
Adewale Fawole ◽  
Kristle Haberichter ◽  
Ishmael Jaiyesimi ◽  
Christopher French
Keyword(s):  
Nuclear Protein ◽  
Nut Midline Carcinoma

scholarly journals Usefulness of Nuclear Protein in Testis (NUT) Immunohistochemistry in the Cytodiagnosis of NUT Midline Carcinoma: A Brief Case Report

2014 ◽  
Vol 48 (4) ◽  
pp. 335 ◽  
Author(s):  
Heae Surng Park ◽  
Yoon Sung Bae ◽  
Sun Och Yoon ◽  
Beom Jin Lim ◽  
Hyun Jun Hong ◽  
...  
Keyword(s):  
Case Report ◽  
Nuclear Protein ◽  
Nut Midline Carcinoma

Nuclear Protein in Testis Midline Carcinomas: A Lethal and Underrecognized Entity

2011 ◽  
Vol 135 (11) ◽  
pp. 1494-1498 ◽  
Author(s):  
Brian N. Davis ◽  
Rouzan G. Karabakhtsian ◽  
Anjana L. Pettigrew ◽  
Susanne M. Arnold ◽  
Chris A. French ◽  
...  
Keyword(s):  
Nuclear Protein ◽  
Chemotherapy Regimen ◽  
Germ Cell Tumors ◽  
Chromosome Analysis ◽  
Immunohistochemical Expression ◽  
Nasal Mass ◽  
Immunohistochemical Stain ◽  
Aggressive Tumors ◽  
Apoptosis And Necrosis

A 54-year-old woman presented with a nasal mass. Biopsy demonstrated undifferentiated tumor cells with extensive apoptosis and necrosis. Chromosome analysis identified a 46,XX,t(15;19)(q13;p13.1) pattern. Nuclear protein in testis (NUT) immunohistochemistry and fluorescence in situ hybridization confirmed NUT rearrangement. A Ewing sarcoma–based chemotherapy regimen and concurrent irradiation obtained a dramatic response; however, the patient died of her disease less than 7 months after initial diagnosis. NUT midline carcinomas are rare, aggressive tumors defined by rearrangement of the NUT gene on 15q14. A solitary translocation involving 15q14 is usually the sole chromosomal abnormality in these carcinomas. Immunohistochemical expression of NUT in the nuclei of non–germ cell tumors is theoretically diagnostic. More widespread use of a newly available NUT immunohistochemical stain will facilitate the diagnosis of NUT rearranged carcinomas. From the growing numbers of identified cases, effective targeted therapies can be developed.

scholarly journals A 48-Year-Old Male with Cutaneous Metastases of NUT Midline Carcinoma Misdiagnosed as Herpes Zoster

2017 ◽  
Vol 10 (3) ◽  
pp. 987-991 ◽  
Author(s):  
Lauren N. Ko ◽  
Qing Y.  Weng ◽  
Johanna S. Song ◽  
Mackenzie Asel ◽  
Scott R. Granter ◽  
...  
Keyword(s):  
Herpes Zoster ◽  
Nuclear Protein ◽  
Skin Involvement ◽  
Cutaneous Metastases ◽  
Nut Midline Carcinoma ◽  
Dismal Prognosis ◽  
Poorly Differentiated ◽  
Nut Carcinoma ◽  
The Right ◽  
Time Of Presentation

NUT (nuclear protein of the testis) midline carcinoma (NMC) is a rare, poorly differentiated neoplasm with dismal prognosis. Though NMC are often metastatic by the time of presentation, cutaneous metastases have not been well described in the literature. We report a case of NMC in a patient who presented with grouped well-demarcated tender non-ulcerated erythematous nodules on the right mid-back. The lesions were initially diagnosed and treated as herpes zoster. Following failure to improve with antiviral therapy, imaging and skin biopsy revealed that the lesions were in fact cutaneous NUT carcinoma. Although NMC is an uncommon diagnosis, clinicians should be aware that affected patients can develop skin involvement to avoid unnecessary and harmful treatments.

scholarly journals NUT midline carcinoma as a primary lung tumor treated with anlotinib combined with palliative radiotherapy: a case report

2022 ◽  
Vol 17 (1) ◽  
Author(s):  
Jin Jiang ◽  
Yikun Ren ◽  
Chengping Xu ◽  
Xing Lin
Keyword(s):  
Tumor Growth ◽  
Poor Prognosis ◽  
Nuclear Protein ◽  
Lung Tumor ◽  
Combined Therapy ◽  
Palliative Radiotherapy ◽  
Patient Case ◽  
Nut Midline Carcinoma ◽  
Case Presentation ◽  
The Poor

Abstract Background NUT (nuclear protein in testis) midline carcinoma (NMC) is a rapidly progressive tumor arising from midline structures. Recent cases have reported that the poor prognosis with a median survival of 6.7 months and a 2 years overall survival of 19% due to limited treatment. Based on the effect of arotinib on inhibiting tumor growth and angiogenesis. We present one patient case treated with anlotinib and radiotherapy. Case presentation Here, we describe a 33-year old patient who complained of cough and chest pain and was diagnosed as a pulmonary NMC through CT scan, FISH and immunohistochemistry. In addition, we initially demonstrated that anlotinib combined with palliative radiotherapy could significantly prevent the tumor growth in a pulmonary NMC. Conclusion The report indicated that anlotinib combined with palliative radiotherapy could inhibit the tumor progression in a pulmonary NMC, which may provide a combined therapy to pulmonary NMC in the future.

scholarly journals NUT Midline Carcinoma as a Primary Lung Tumor Treated With Anlotinib Combined With Palliative Radiotherapy: a Case Report

2021 ◽  
Author(s):  
Jin Jiang ◽  
Yikun Ren ◽  
Chengping Xu ◽  
Xing Lin
Keyword(s):  
Tumor Growth ◽  
Poor Prognosis ◽  
Nuclear Protein ◽  
Lung Tumor ◽  
Combined Therapy ◽  
Palliative Radiotherapy ◽  
Patient Case ◽  
Nut Midline Carcinoma ◽  
Case Presentation ◽  
The Poor

Abstract Background: NUT (nuclear protein in testis) midline carcinoma (NMC) is a rapidly progressive tumor arising from midline structures. Recent cases have reported that the poor prognosis with a median survival of 6.7 months and a 2 years overall survival of 19% due to limited treatment. Based on the effect of arotinib on inhibiting tumor growth and angiogenesis. We present one patient case treated with anlotinib and radiotherapy.Case presentation: Here, we describe a 33-year old patient who complained of cough and chest pain and was diagnosed as a pulmonary NMC through CT scan, FISH and immunohistochemistry. In addition, we initially demonstrated that anlotinib combined with palliative radiotherapy could significantly prevent the tumor growth in a pulmonary NMC.Conclusion: The report indicated that anlotinib combined with palliative radiotherapy could inhibit the tumor progression in a pulmonary NMC, which may provide a combined therapy to pulmonary NMC in the future.

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