scholarly journals 3D printing of customized key biomaterials genomics for bone regeneration

2022 ◽  
Vol 26 ◽  
pp. 101346
Author(s):  
Boqing Zhang ◽  
Wenzhao Wang ◽  
Xingyu Gui ◽  
Ping Song ◽  
Haoyuan Lei ◽  
...  
Keyword(s):  
3D Printing ◽  
Bone Regeneration

scholarly journals Cobalt-doped bioceramic scaffolds fabricated by 3D printing show enhanced osteogenic and angiogenic properties for bone repair

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Jungang Li ◽  
Chaoqian Zhao ◽  
Chun Liu ◽  
Zhenyu Wang ◽  
Zeming Ling ◽  
...  
Keyword(s):  
Compressive Strength ◽  
3D Printing ◽  
Bone Regeneration ◽  
Doping Concentration ◽  
Artificial Bone ◽  
Bone Defect Repair ◽  
Co Doping ◽  
Defect Repair ◽  
Co Doped

Abstract Background The bone regeneration of artificial bone grafts is still in need of a breakthrough to improve the processes of bone defect repair. Artificial bone grafts should be modified to enable angiogenesis and thus improve osteogenesis. We have previously revealed that crystalline Ca10Li(PO4)7 (CLP) possesses higher compressive strength and better biocompatibility than that of pure beta-tricalcium phosphate (β-TCP). In this work, we explored the possibility of cobalt (Co), known for mimicking hypoxia, doped into CLP to promote osteogenesis and angiogenesis. Methods We designed and manufactured porous scaffolds by doping CLP with various concentrations of Co (0, 0.1, 0.25, 0.5, and 1 mol%) and using 3D printing techniques. The crystal phase, surface morphology, compressive strength, in vitro degradation, and mineralization properties of Co-doped and -undoped CLP scaffolds were investigated. Next, we investigated the biocompatibility and effects of Co-doped and -undoped samples on osteogenic and angiogenic properties in vitro and on bone regeneration in rat cranium defects. Results With increasing Co-doping level, the compressive strength of Co-doped CLP scaffolds decreased in comparison with that of undoped CLP scaffolds, especially when the Co-doping concentration increased to 1 mol%. Co-doped CLP scaffolds possessed excellent degradation properties compared with those of undoped CLP scaffolds. The (0.1, 0.25, 0.5 mol%) Co-doped CLP scaffolds had mineralization properties similar to those of undoped CLP scaffolds, whereas the 1 mol% Co-doped CLP scaffolds shown no mineralization changes. Furthermore, compared with undoped scaffolds, Co-doped CLP scaffolds possessed excellent biocompatibility and prominent osteogenic and angiogenic properties in vitro, notably when the doping concentration was 0.25 mol%. After 8 weeks of implantation, 0.25 mol% Co-doped scaffolds had markedly enhanced bone regeneration at the defect site compared with that of the undoped scaffold. Conclusion In summary, CLP doped with 0.25 mol% Co2+ ions is a prospective method to enhance osteogenic and angiogenic properties, thus promoting bone regeneration in bone defect repair.

scholarly journals 3D Printing for Bone Regeneration

2020 ◽  
Vol 18 (5) ◽  
pp. 505-514
Author(s):  
Amit Bandyopadhyay ◽  
Indranath Mitra ◽  
Susmita Bose
Keyword(s):  
3D Printing ◽  
Bone Regeneration

scholarly journals 3D printable SiO2 nanoparticle ink for patient specific bone regeneration

RSC Advances ◽  
2019 ◽  
Vol 9 (41) ◽  
pp. 23832-23842 ◽  
Author(s):  
Uday Kiran Roopavath ◽  
Raghav Soni ◽  
Urbashi Mahanta ◽  
Atul Suresh Deshpande ◽  
Subha Narayan Rath
Keyword(s):  
3D Printing ◽  
Bone Regeneration ◽  
Patient Specific ◽  
Hydrogel Composite ◽  
Sio2 Nanoparticle ◽  
Nanoparticle Ink

3D printing of a complex and irregular virtual defect using SiO2 nanoparticle and hydrogel composite ink for patient specific defect fabrication.

scholarly journals Enzyme degradable star polymethacrylate/silica hybrid inks for 3D printing of tissue scaffolds

2020 ◽  
Vol 1 (9) ◽  
pp. 3189-3199
Author(s):  
Anna Li Volsi ◽  
Francesca Tallia ◽  
Haffsah Iqbal ◽  
Theoni K. Georgiou ◽  
Julian R. Jones
Keyword(s):  
3D Printing ◽  
Bone Regeneration ◽  
Tissue Scaffolds ◽  
Star Polymer ◽  
Polymer Architecture ◽  
Organic Hybrid ◽  
3D Printed ◽  
Silica Hybrid

We report the first enzyme cleavable inorganic–organic hybrid “inks” that can be 3D printed as scaffolds for bone regeneration and investigate the effect of star polymer architecture on their properties.

Customized Surgical Protocols for Guided Bone Regeneration Using 3D Printing Technology

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Paloma Manzano Romero ◽  
Valentino Vellone ◽  
Francesco Maffia ◽  
Giuseppe Cicero
Keyword(s):  
3D Printing ◽  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Printing Technology ◽  
3D Printing Technology
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