Radiosynthesis of 1-[18F]fluoroethyl-L-tryptophan as a novel potential amino acid PET tracer

2012 ◽  
Vol 70 (4) ◽  
pp. 676-680 ◽  
Author(s):  
Ting Sun ◽  
Ganghua Tang ◽  
Hua Tian ◽  
Xiaoyan Wang ◽  
Xianghua Chen ◽  
...  
Keyword(s):  
Amino Acid ◽  
Pet Tracer ◽  
Amino Acid Pet

scholarly journals 18F-FACBC PET/MRI in the evaluation of human brain metastases: a case report

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Knut Johannessen ◽  
Erik Magnus Berntsen ◽  
Håkon Johansen ◽  
Tora S. Solheim ◽  
Anna Karlberg ◽  
...  
Keyword(s):  
Case Report ◽  
Clinical Practice ◽  
Amino Acid ◽  
Brain Metastases ◽  
Metastatic Cancer ◽  
Low Grade ◽  
Pet Tracer ◽  
Before And After ◽  
Amino Acid Pet ◽  
And Function

Abstract Background Patients with metastatic cancer to the brain have a poor prognosis. In clinical practice, MRI is used to delineate, diagnose and plan treatment of brain metastases. However, MRI alone is limited in detecting micro-metastases, delineating lesions and discriminating progression from pseudo-progression. Combined PET/MRI utilises superior soft tissue images from MRI and metabolic data from PET to evaluate tumour structure and function. The amino acid PET tracer 18F-FACBC has shown promising results in discriminating high- and low-grade gliomas, but there are currently no reports on its use on brain metastases. This is the first study to evaluate the use of 18F-FACBC on brain metastases. Case presentation A middle-aged female patient with brain metastases was evaluated using hybrid PET/MRI with 18F-FACBC before and after stereotactic radiotherapy, and at suspicion of recurrence. Static/dynamic PET and contrast-enhanced T1 MRI data were acquired and analysed. This case report includes the analysis of four 18F-FACBC PET/MRI examinations, investigating their utility in evaluating functional and structural metastasis properties. Conclusion Analysis showed high tumour-to-background ratios in brain metastases compared to other amino acid PET tracers, including high uptake in a very small cerebellar metastasis, suggesting that 18F-FACBC PET can provide early detection of otherwise overlooked metastases. Further studies to determine a threshold for 18F-FACBC brain tumour boundaries and explore its utility in clinical practice should be performed.

scholarly journals Maximizing the use of batch production of 18F-FDOPA for imaging of brain tumors to increase availability of hybrid PET/MR imaging in clinical setting

2020 ◽  
Author(s):  
M S Aboian ◽  
R Barajas ◽  
J Shatalov ◽  
V Ravanfar ◽  
E Bahroos ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Amino Acid ◽  
Brain Tumors ◽  
Pet Imaging ◽  
Critical Role ◽  
Normal Brain ◽  
Mri Imaging ◽  
Pet Tracer ◽  
Amino Acid Pet ◽  
The Cost

Abstract Background Amino acid PET imaging of brain tumors has been shown to play an important role in predicting tumor grade, delineation of tumor margins, and differentiating tumor recurrence from the background of post-radiation changes, but is not commonly used in clinical practice due to high cost. We propose that PET/MRI imaging of patients grouped to the day of tracer radiosynthesis will significantly decrease the cost of PET imaging, which will improve patient access to PET. Methods Seventeen patients with either primary brain tumors or metastatic brain tumors were recruited for imaging on 3T PET/MRI and were scanned on 4 separate days in groups of 3-5 patients. The first group of consecutively imaged patients contained three patients, followed by two groups of 5 patients, and last group of 4 patients. Results For each of the patients, standard of care gadolinium enhanced MRI and dynamic PET imaging with 18F-FDOPA amino acid tracer was obtained. The total cost savings of scanning 17 patients in batches of 4 as opposed to individual radiosynthesis was 48.5% ($28,321). Semiquantitative analysis of tracer uptake in normal brain were performed with appropriate accumulation and expected subsequent washout. Conclusion Amino acid PET tracers have been shown to play a critical role in characterization of brain tumors but their adaptation to clinical practice has been limited due to high cost of PET. Scheduling patient imaging to maximally utilize the radiosynthesis of imaging tracer significantly reduces the cost of PET and results in increased availability of PET tracer use in neuro-oncology.

Amino Acid PET Tracer Accumulation in Cortical Ischemia

2010 ◽  
Vol 35 (11) ◽  
pp. 907-908 ◽  
Author(s):  
Christof Rottenburger ◽  
Soroush Doostkam ◽  
Marco Prinz ◽  
Stephan Meckel ◽  
Guido Nikkhah ◽  
...  
Keyword(s):  
Amino Acid ◽  
Pet Tracer ◽  
Amino Acid Pet ◽  
Cortical Ischemia ◽  
Tracer Accumulation

scholarly journals Synthesis and preliminary biological evaluation of O-2((2-[18F]fluoroethyl)methylamino)ethyltyrosine ([18F]FEMAET) as a potential cationic amino acid PET tracer for tumor imaging

Amino Acids ◽  
2014 ◽  
Vol 46 (8) ◽  
pp. 1947-1959 ◽  
Author(s):  
Aristeidis Chiotellis ◽  
Adrienne Müller ◽  
Karin Weyermann ◽  
Dominique S. Leutwiler ◽  
Roger Schibli ◽  
...  
Keyword(s):  
Amino Acid ◽  
Tumor Imaging ◽  
Biological Evaluation ◽  
Cationic Amino Acid ◽  
Pet Tracer ◽  
Amino Acid Pet

scholarly journals S-11C-Methyl-L-Cysteine: A New Amino Acid PET Tracer for Cancer Imaging

2011 ◽  
Vol 52 (2) ◽  
pp. 287-293 ◽  
Author(s):  
H. Deng ◽  
X. Tang ◽  
H. Wang ◽  
G. Tang ◽  
F. Wen ◽  
...  
Keyword(s):  
Amino Acid ◽  
Cancer Imaging ◽  
Pet Tracer ◽  
Amino Acid Pet

Synthesis and preliminary biological evaluation of S-11C-methyl-d-cysteine as a new amino acid PET tracer for cancer imaging

Amino Acids ◽  
2014 ◽  
Vol 47 (4) ◽  
pp. 719-727 ◽  
Author(s):  
Tingting Huang ◽  
Ganghua Tang ◽  
Hongliang Wang ◽  
Dahong Nie ◽  
Xiaolan Tang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Cancer Imaging ◽  
Biological Evaluation ◽  
Pet Tracer ◽  
Amino Acid Pet

scholarly journals NI-29 * DIAGNOSIS OF PSEUDOPROGRESSION IN PATIENTS WITH GLIOBLASTOMA USING AMINO ACID PET

2014 ◽  
Vol 16 (suppl 5) ◽  
pp. v144-v144
Author(s):  
N. Galldiks ◽  
V. Dunkl ◽  
G. Stoffels ◽  
M. Hutterer ◽  
M. Rapp ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Pet

Amino acid PET monitoring in gliomas

2015 ◽  
Vol 8 (2) ◽  
pp. 115-118 ◽  
Author(s):  
Ulrich Roelcke
Keyword(s):  
Amino Acid ◽  
Amino Acid Pet

scholarly journals P16.10 * DIAGNOSIS OF PSEUDOPROGRESSION IN PATIENTS WITH GLIOBLASTOMA USING AMINO ACID PET

2014 ◽  
Vol 16 (suppl 2) ◽  
pp. ii80-ii80
Author(s):  
N. Galldiks ◽  
V. Dunkl ◽  
G. Stoffels ◽  
M. Hutterer ◽  
M. Rapp ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Pet

High-Grade Brain Tumours: Evaluation of New Brain Lesions by Amino Acid PET

2011 ◽  
pp. 111-117
Author(s):  
Robert Pichler ◽  
Sabine Spiegl-Kreinecker ◽  
Gabriele Wurm
Keyword(s):  
Amino Acid ◽  
Brain Tumours ◽  
Brain Lesions ◽  
High Grade ◽  
Amino Acid Pet
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