Does Sickle Cell Disease Increase Risk of Adverse Outcomes Following Total Hip and Knee Arthroplasty? A Nationwide Database Study

2015 ◽  
Vol 30 (4) ◽  
pp. 547-551 ◽  
Author(s):  
Dean C. Perfetti ◽  
Matthew R. Boylan ◽  
Qais Naziri ◽  
Harpal S. Khanuja ◽  
William P. Urban
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Knee Arthroplasty ◽  
Adverse Outcomes ◽  
Cell Disease ◽  
Database Study ◽  
Total Hip ◽  
Nationwide Database ◽  
Increase Risk ◽  
Hip And Knee Arthroplasty

Cementless Total HIP Replacements in Sickle Cell Disease

2015 ◽  
Vol 26 (2) ◽  
pp. 186-192 ◽  
Author(s):  
Christopher M. Jack ◽  
Jo Howard ◽  
Emad S. Aziz ◽  
Rachel Kesse-Adu ◽  
Marcus J. Bankes
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Total Hip ◽  
Total Hip Replacements ◽  
Hip Replacements

scholarly journals Total hip replacement in sickle cell disease

2002 ◽  
Vol 26 (3) ◽  
pp. 157-161 ◽  
Author(s):  
Al-Mousawi F. ◽  
Malki A. ◽  
Al-Aradi A. ◽  
Al-Bagali M. ◽  
Al-Sadadi A. ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Total Hip Replacement ◽  
Sickle Cell ◽  
Hip Replacement ◽  
Cell Disease ◽  
Total Hip

scholarly journals Procalcitonin to Reduce Antibiotic Exposure during Acute Chest Syndrome in Adult Patients with Sickle-Cell Disease

2020 ◽  
Vol 9 (11) ◽  
pp. 3718
Author(s):  
Keyvan Razazi ◽  
Ségolène Gendreau ◽  
Elise Cuquemelle ◽  
Mehdi Khellaf ◽  
Constance Guillaud ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Bacterial Infection ◽  
Sickle Cell ◽  
Major Complication ◽  
Adverse Outcomes ◽  
Acute Chest Syndrome ◽  
Antibiotic Exposure ◽  
Cell Disease ◽  
Intervention Phase ◽  
Entire Cohort

Acute chest syndrome (ACS) is a major complication of sickle-cell disease. Bacterial infection is one cause of ACS, so current guidelines recommend the routine use of antibiotics. We performed a prospective before–after study in medical wards and an intensive-care unit (ICU). During the control phase, clinicians were blinded to procalcitonin concentration results. We built an algorithm using the obtained measurements to hasten antibiotic cessation after three days of treatment if bacterial infection was not documented, and procalcitonin concentrations were all <0.5 μg/L. During the intervention period, the procalcitonin algorithm was suggested to physicians as a guide for antibiotic therapy. The primary endpoint was the number of days alive without antibiotics at Day 21. One-hundred patients were analyzed (103 ACS episodes, 60 in intervention phase). Possible or proven lung infection was diagnosed during 13% of all ACS episodes. The number of days alive without antibiotics at Day 21 was higher during the intervention phase: 15 [14–18] vs. 13 [13,14] days (p = 0.001). More patients had a short (≤3 days) antibiotic course during intervention phase: 31% vs 9% (p = 0.01). There was neither infection relapse nor pulmonary superinfection in the entire cohort. A procalcitonin-guided strategy to prescribe antibiotics in patients with ACS may reduce antibiotic exposure with no apparent adverse outcomes.

scholarly journals Prevalence and risk factors for venous thromboembolism in children with sickle cell disease: an administrative database study

2018 ◽  
Vol 2 (3) ◽  
pp. 285-291 ◽  
Author(s):  
Riten Kumar ◽  
Joseph Stanek ◽  
Susan Creary ◽  
Amy Dunn ◽  
Sarah H. O’Brien
Keyword(s):  
Risk Factors ◽  
Retrospective Study ◽  
Venous Thromboembolism ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Administrative Database ◽  
Similar Data ◽  
Cell Disease ◽  
Database Study ◽  
Key Points

Key Points Adults with SCD have an increased incidence of VTE, but similar data in children are lacking. In this 7-year, multicenter retrospective study, 1.7% of children with SCD developed VTE.

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