Subacromial Bursa–Derived Cells Demonstrate High Proliferation Potential Regardless of Patient Demographics and Rotator Cuff Tear Characteristics

2020 ◽  
Vol 36 (11) ◽  
pp. 2794-2802 ◽  
Author(s):  
Lukas N. Muench ◽  
Joshua B. Baldino ◽  
Daniel P. Berthold ◽  
Cameron Kia ◽  
Amir Lebaschi ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Rotator Cuff Tear ◽  
Subacromial Bursa ◽  
Patient Demographics ◽  
Cuff Tear ◽  
Proliferation Potential

scholarly journals MicroRNA-29a Mitigates Subacromial Bursa Fibrosis in Rotator Cuff Lesion with Shoulder Stiffness

2019 ◽  
Vol 20 (22) ◽  
pp. 5742 ◽  
Author(s):  
Jih-Yang Ko ◽  
Wei-Shiung Lian ◽  
Tsai-Chen Tsai ◽  
Yu-Shan Chen ◽  
Chin-Kuei Hsieh ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Rotator Cuff Tear ◽  
Shoulder Function ◽  
Pathological Feature ◽  
Subacromial Bursa ◽  
Shoulder Disorder ◽  
Shoulder Stiffness ◽  
Cuff Tear ◽  
Rotator Cuff Lesion

Rotator cuff lesion with shoulder stiffness is a major cause of shoulder pain and motionlessness. Subacromial bursa fibrosis is a prominent pathological feature of the shoulder disorder. MicroRNA-29a (miR-29a) regulates fibrosis in various tissues; however, the miR-29a action to subacromial bursa fibrosis remains elusive. Here, we reveal that subacromial synovium in patients with rotator cuff tear with shoulder stiffness showed severe fibrosis, hypertrophy, and hyperangiogenesis histopathology along with significant increases in fibrotic matrices collagen (COL) 1A1, 3A1, and 4A1 and inflammatory cytokines, whereas miR-29a expression was downregulated. Supraspinatus and infraspinatus tenotomy-injured shoulders in transgenic mice overexpressing miR-29a showed mild swelling, vascularization, fibrosis, and regular gait profiles as compared to severe rotator cuff damage in wild-type mice. Treatment with miR-29a precursor compromised COL3A1 production and hypervascularization in injured shoulders. In vitro, gain of miR-29a function attenuated COL3A1 expression through binding to the 3’-untranslated region (3′-UTR) of COL3A1 in inflamed tenocytes, whereas silencing miR-29a increased the matrix expression. Taken together, miR-29a loss is correlated with subacromial bursa inflammation and fibrosis in rotator cuff tear with shoulder stiffness. miR-29a repressed subacromial bursa fibrosis through directly targeting COL3A1 mRNA, improving rotator cuff integrity and shoulder function. Collective analysis offers a new insight into the molecular mechanism underlying rotator cuff tear with shoulder stiffness. This study also highlights the remedial potential of miR-29a precursor for alleviating the shoulder disorder.

IL-1β mediates NGF and COX-2 expression through transforming growth factor-activating kinase 1 in subacromial bursa cells derived from rotator cuff tear patients

2019 ◽  
Vol 24 (5) ◽  
pp. 925-929
Author(s):  
Naoshige Nagura ◽  
Kentaro Uchida ◽  
Tomonori Kenmoku ◽  
Gen Inoue ◽  
Mitsufumi Nakawaki ◽  
...  
Keyword(s):  
Growth Factor ◽  
Rotator Cuff ◽  
Rotator Cuff Tear ◽  
Transforming Growth Factor ◽  
Subacromial Bursa ◽  
Cuff Tear ◽  
Cox 2

scholarly journals The role of tendon and subacromial bursa in rotator cuff tear pain: a clinical and histopathological study

2015 ◽  
Vol 24 (12) ◽  
pp. 3779-3786 ◽  
Author(s):  
Claudio Chillemi ◽  
Vincenzo Petrozza ◽  
Vincenzo Franceschini ◽  
Luca Garro ◽  
Alberto Pacchiarotti ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Rotator Cuff Tear ◽  
Histopathological Study ◽  
Subacromial Bursa ◽  
Cuff Tear

Neurohistology of the subacromial bursa in rotator cuff tear

1997 ◽  
Vol 2 (5) ◽  
pp. 295-300 ◽  
Author(s):  
Tomita Yasuharu ◽  
Jiro Ozaki ◽  
Goro Sakurai ◽  
Tosinori Kondo ◽  
Kimio Nakagaki ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Rotator Cuff Tear ◽  
Subacromial Bursa ◽  
Cuff Tear

Accuracy of Rotator Cuff Tears and Tendinosis Diagnoses on Shoulder Ultrasound Performed by a Short-experienced Operator

2018 ◽  
Vol 1 ◽  
pp. 9
Author(s):  
Harshad Arvind Vanjare ◽  
Jyoti Panwar
Keyword(s):  
Rotator Cuff ◽  
Negative Predictive Value ◽  
Rotator Cuff Tear ◽  
Predictive Value ◽  
Rotator Cuff Tears ◽  
Mri Findings ◽  
Cuff Tear ◽  
Experienced Operator ◽  
Magnetic Resonance Imaging Mri ◽  
Sensitivity Specificity

Objective The objective of the study was to assess the accuracy of ultrasound examination for the diagnosis of rotator cuff tear and tendinosis performed by a short experienced operator, compared to magnetic resonance imaging (MRI) results. Method A total of 70 subjects suspected to have rotator cuff tear or tendinosis and planned for shoulder MRI were included in the study. Shoulder ultrasound was performed either before or after the MRI scan on the same day. Ultrasound operator had a short experience in performing an ultrasound of the shoulder. Ultrasound findings were correlated to MRI findings. Results Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for the diagnosis of tendinosis were 58%, 84%, 63%, 80%, and 75%, respectively, and it was 68%, 91%, 73%, 88%, and 85%, respectively, for the diagnosis of rotator cuff tear. Conclusions Sensitivity for diagnosing rotator cuff tear or tendinosis was moderate but had a higher negative predictive value. Thus, the ultrasound operator with a short experience in performing shoulder ultrasound had moderate sensitivity in diagnosing tendinosis or tears; however, could exclude them with confidence.

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