Association of interleukin-6 (IL-6)-174G/C gene polymorphism with cardiovascular disease in patients with rheumatoid arthritis: The role of obesity and smoking

The pleiotropic effects of statins, especially the anti-inflammatory and immunomodulatory ones, indicate that their therapeutic potential might extend beyond cholesterol lowering and cardiovascular disease to other inflammatory disorders such as rheumatoid arthritis. Therefore, we undertook a prospective cohort study to evaluate the efficacy and safety of simvastatin used for inflammation control in patients with rheumatoid arthritis. One hundred patients with active rheumatoid arthritis divided into two equal groups (the study one who received 20 mg/day of simvastatin in addition to prior DMARDs and the control one) were followed up over six months during three study visits. The results of the study support the fact that simvastatin at a dose of 20 mg/day has a low anti-inflammatory effect in patients with rheumatoid arthritis with a good safety profile.

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The role of interleukin-6 in rheumatoid arthritis-associated osteoporosis

Osteoporosis International ◽

10.1007/s00198-010-1192-7 ◽

2010 ◽

Vol 21 (8) ◽

pp. 1287-1293 ◽

Cited By ~ 42

Author(s):

C. J. Edwards ◽

E. Williams

Keyword(s):

Rheumatoid Arthritis ◽

Interleukin 6

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Interleukin-6 inhibition and cardiovascular disease in patients with rheumatoid arthritis

Terapevticheskii arkhiv ◽

10.17116/terarkh201688593-101 ◽

2016 ◽

Vol 88 (5) ◽

pp. 93 ◽

Cited By ~ 1

Author(s):

T. V. Popkova ◽

D. S. Novikova ◽

E. L. Nasonov

Keyword(s):

Rheumatoid Arthritis ◽

Cardiovascular Disease ◽

Interleukin 6

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Understanding the Role of Interleukin-6 (IL-6) in the Joint and Beyond: A Comprehensive Review of IL-6 Inhibition for the Management of Rheumatoid Arthritis

Rheumatology and Therapy ◽

10.1007/s40744-020-00219-2 ◽

2020 ◽

Vol 7 (3) ◽

pp. 473-516

Author(s):

Ennio G. Favalli

Keyword(s):

Rheumatoid Arthritis ◽

Interleukin 6 ◽

Comprehensive Review

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Role of Interleukin 6 Inhibitors in the Management of Rheumatoid Arthritis

JCR Journal of Clinical Rheumatology ◽

10.1097/rhu.0000000000001293 ◽

2019 ◽

Vol Publish Ahead of Print ◽

Cited By ~ 2

Author(s):

Ronald Man Lung Yip ◽

Cheuk Wan Yim

Keyword(s):

Rheumatoid Arthritis ◽

Interleukin 6

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Interleukin-6 in Rheumatoid Arthritis

International Journal of Molecular Sciences ◽

10.3390/ijms21155238 ◽

2020 ◽

Vol 21 (15) ◽

pp. 5238 ◽

Cited By ~ 6

Author(s):

Franco Pandolfi ◽

Laura Franza ◽

Valentina Carusi ◽

Simona Altamura ◽

Gloria Andriollo ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Interleukin 6 ◽

Gold Standard ◽

Standard Treatment ◽

Therapeutic Options ◽

Inflammatory Pathways ◽

Health And Disease ◽

No Gold Standard

The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent years, particularly during the recent COVID-19 pandemic. The inflammatory pathways in which IL-6 is involved are also partly responsible of the development and progression of rheumatoid arthritis (RA), opening interesting perspectives in terms of therapy. Anti-IL-6 drugs are being used with variable degrees of success in other diseases and are being tested in RA. Results have been encouraging, particularly when anti-IL-6 has been used with other drugs, such as metothrexate (MTX). In this review we discuss the main immunologic aspects that make anti-IL-6 a good candidate in RA, but despite the main therapeutic options available to target IL-6, no gold standard treatment has been established so far.

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