Monocyte subsets in coronary artery disease and their associations with markers of inflammation and fibrinolysis

2014 ◽  
Vol 234 (1) ◽  
pp. 4-10 ◽  
Author(s):  
Eduard Shantsila ◽  
Luke D. Tapp ◽  
Benjamin J. Wrigley ◽  
Burak Pamukcu ◽  
Stavros Apostolakis ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Monocyte Subsets ◽  
Markers Of Inflammation ◽  
Artery Disease

Circulating levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) are associated with monocyte subsets in patients with stable coronary artery disease

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
KA Krychtiuk ◽  
M Lenz ◽  
P Hohensinner ◽  
K Distelmaier ◽  
L Schrutka ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Stable Coronary Artery Disease ◽  
Statin Treatment ◽  
Lipid Lowering ◽  
Monocyte Subsets ◽  
Proprotein Convertase ◽  
Artery Disease ◽  
Circulating Levels ◽  
Classical Monocytes

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): FWF Background and aims Proprotein convertase subtilisin/kexin type-9 (PCSK9) is an enzyme promoting the degradation of low-density lipoprotein receptors (LDL-R) in hepatocytes. Inhibition of PCSK9 has emerged as a novel target for lipid-lowering therapy. Monocytes are crucially involved in the pathogenesis of atherosclerosis and can be divided into three subsets. The aim of this study was to examine whether circulating levels of PCSK9 are associated with monocyte subsets. Methods We included 69 patients with stable coronary artery disease. PCSK9 levels were measured and monocyte subsets were assessed by flow cytometry and divided into classical monocytes (CD14++CD16-; CM), intermediate monocytes (CD14++CD16+; IM) and non-classical monocytes (CD14 + CD16++; NCM). Results Mean age was 64 years and 80% of patients were male. Patients on statin treatment (n = 55) showed higher PCSK9-levels (245.4 (206.0-305.5) ng/mL) as opposed to those without statin treatment (186.1 (162.3-275.4) ng/mL; p = 0.05). In patients on statin treatment, CM correlated with circulating PCSK9 levels (R = 0.29; p = 0.04), while NCM showed an inverse correlation with PCSK9 levels (R=-0.33; p = 0.02). Patients with PCSK9 levels above the median showed a significantly higher proportion of CM as compared to patients with PCSK-9 below the median (83.5 IQR 79.2-86.7 vs. 80.4, IQR 76.5-85.2%; p = 0.05). Conversely, PCSK9 levels >median were associated with a significantly lower proportion of NCM as compared to those with PCSK9 <median (10.2, IQR 7.3-14.6 vs. 14.3, IQR 10.9-18.7%; p = 0.02). In contrast, IM showed no association with PCSK-9 levels. Conclusions We hereby provide a novel link between PCSK9 regulation, innate immunity and atherosclerotic disease in statin-treated patients.

Association between Lp-PLA2 and coronary artery disease: Focus on its relationship with lipoproteins and markers of inflammation and hemostasis

2005 ◽  
Vol 182 (1) ◽  
pp. 181-188 ◽  
Author(s):  
Natalie Khuseyinova ◽  
Armin Imhof ◽  
Dietrich Rothenbacher ◽  
Gerlinde Trischler ◽  
Silke Kuelb ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Markers Of Inflammation ◽  
Artery Disease ◽  
Disease Focus

scholarly journals Single Endothelial Cell mRNA Sequencing Better Captures the Severity of Coronary Artery Disease Than Targeted Total Arterial Markers of Inflammation and Senescence

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Pauline Mury ◽  
Florian Wünnemann ◽  
Mélissa Beaudoin ◽  
Nathalie Thorin-Trescases ◽  
Yves Hébert ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Endothelial Cell ◽  
Coronary Artery ◽  
Mrna Sequencing ◽  
Markers Of Inflammation ◽  
Artery Disease

Regulation of EMMPRIN (CD147) on monocyte subsets in patients with symptomatic coronary artery disease

2015 ◽  
Vol 135 (6) ◽  
pp. 1160-1164 ◽  
Author(s):  
Henrik Sturhan ◽  
Saskia N.I.v. Ungern-Sternberg ◽  
Harald Langer ◽  
Meinrad Gawaz ◽  
Tobias Geisler ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Monocyte Subsets ◽  
Symptomatic Coronary Artery Disease ◽  
Artery Disease

Atheroprotective Krüppel-like factor 4 is downregulated in monocyte subsets of patients with coronary artery disease

2013 ◽  
Vol 110 (11) ◽  
pp. 1080-1082 ◽  
Author(s):  
Frauke S. Czepluch ◽  
Hendrik Kuschicke ◽  
Claudia Dellas ◽  
Joachim Riggert ◽  
Gerd Hasenfuss ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Monocyte Subsets ◽  
Artery Disease

scholarly journals Disturbed Lipid Metabolism in Diabetic Patients with Manifest Coronary Artery Disease Is Associated with Enhanced Inflammation

2021 ◽  
Vol 18 (20) ◽  
pp. 10892
Author(s):  
Katja Buschmann ◽  
Yves Gramlich ◽  
Ryan Chaban ◽  
Matthias Oelze ◽  
Ulrich Hink ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Coronary Artery Disease ◽  
Lipid Metabolism ◽  
Coronary Artery ◽  
Right Atrial ◽  
Oxidative Enzymes ◽  
Diabetic Patients ◽  
Markers Of Inflammation ◽  
Insulin Dependent ◽  
Artery Disease

Background: Diabetic vasculopathy plays an important role in the pathophysiology of coronary artery disease (CAD) with oxidative stress as a strong mediator. This study aims to elucidate the underlying pathomechanisms of diabetic cardiac vasculopathy leading to coronary disease with an emphasis on the role of oxidative stress. Therefore, novel insights into antioxidant pathways might contribute to new strategies in the treatment and prevention of diabetic CAD. Methods: In 20 patients with insulin-dependent or non-insulin dependent diabetes mellitus (IDDM/NIDDM) and 39 non-diabetic (CTR) patients, myocardial markers of oxidative stress, vasoactive proteins, endothelial nitric oxide synthase (eNOS), activated phosphorylated eNOS (p-eNOS), and antioxidant enzymes, e.g., tetrahydrobiopterin generating dihydrofolate reductase (DHFR), heme oxygenase (HO-1), as well as serum markers of inflammation, e.g., E-selectin, interleukin-6 (IL-6), and lipid metabolism, e.g., high- and low-density lipoptrotein (HDL- and LDL-cholesterol) were determined in specimens of right atrial tissue and in blood samples from type 2 diabetic and non-diabetic patients undergoing coronary artery bypass graft (CABG) surgery. Results: IDDM/NIDDM increased markers of inflammation (e.g., E-selectin, p = 0.005 and IL-6, p = 0.051), decreased the phosphorylated myocardial p-eNOS (p = 0.032), upregulated the myocardial stress response protein HO-1 (p = 0.018), and enhanced the serum LDL-/HDL-cholesterol ratio (p = 0.019). However, the oxidative stress markers in the myocardium and the expression of vasoactive proteins (eNOS, DHFR) showed only marginal adverse changes in patients with IDDM/NIDDM. Conclusion: Dyslipidemia and myocardial inflammation seem to be the major determinants of diabetic CAD complications. Dysregulation in pro-oxidative enzymes might be attributable to the severity of CAD and oxidative stress levels in all included patients undergoing CABG.

Sign in / Sign up

Export Citation Format

Share Document