Potential pathological roles for oxidized low-density lipoprotein and scavenger receptors SR-AI, CD36, and LOX-1 in aortic valve stenosis

2014 ◽  
Vol 235 (2) ◽  
pp. 398-407 ◽  
Author(s):  
Suvi Syväranta ◽  
Mervi Alanne-Kinnunen ◽  
Katariina Öörni ◽  
Riina Oksjoki ◽  
Markku Kupari ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Scavenger Receptors ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

Abstract 12822: Increased Expression and Serum Levels of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Patients With Aortic Valve Stenosis

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Tomotaka Yoshiyama ◽  
Kei Yunoki ◽  
Ryushi Komatsu ◽  
Kazuo Haze ◽  
Takahiko Naruko ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Low Density ◽  
Lipoprotein Receptor ◽  
Oxidized Low Density Lipoprotein ◽  
Control Subjects ◽  
Density Lipoprotein Receptor

Background: The development of aortic valve stenosis (AS) involves multiple events, including inflammation and lipid deposition and oxidation. Circulating levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) play an important role in the development and progression of atherosclerosis. The aims of this study were to investigate the serum levels of sLOX-1 in patients with AS and also examine the expression of LOX-1 immunohistochemically in aortic valve specimens from these patients. Methods: Serum sLOX-1 levels were measured in patients with AS (n=128), stable angina pectoris (SAP, n=343) and in 53 control subjects using a sandwich ELISA method. Frozen aortic valve samples were also obtained surgically from a cohort of 20 AS patients. In addition, frozen aortic valve specimens were obtained at autopsy from individuals who died of non-cardiovascular causes (n = 11, mean age 68 yr) as a reference. Immunostaining of the samples was performed using antibodies against smooth muscle cells, macrophages, T-lymphocytes, neutrophils, microvessels, and LOX-1. Results: Serum sLOX-1 levels were significantly higher in AS patients compared with SAP patients ( P <0.0005) or control subjects ( P <0.0001). There were no differences in serum sLOX-1 levels between AS patients with or without coronary artery disease. Immunohistochemical staining showed that the LOX-1-positive area, as a percentage of the total area, was significantly (P<0.01) higher in AS patients compared with reference cases. Double immunostaining for LOX-1 and macrophages revealed that the vast majority of LOX-1-positive cells were macrophages. Conclusions: This study demonstrates for the first time that serum sLOX-1 levels are elevated in patients with AS, and AS lesions contain a significantly higher percentage of LOX-1-positive macrophages. These findings suggest that LOX-1, a marker of oxidative stress, may play an important role in the development of aortic valve stenosis.

Coarse Grained Molecular Dynamics of Engineered Macromolecules for the Inhibition of Oxidized Low-Density Lipoprotein Uptake by Macrophage Scavenger Receptors

2013 ◽  
Vol 14 (8) ◽  
pp. 2499-2509 ◽  
Author(s):  
Michael D. Tomasini ◽  
Kyle Zablocki ◽  
Latrisha K. Petersen ◽  
Prabhas V. Moghe ◽  
M. Silvina Tomassone
Keyword(s):  
Molecular Dynamics ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Coarse Grained ◽  
Scavenger Receptors ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Lipoprotein Uptake ◽  
Coarse Grained Molecular Dynamics

scholarly journals Development and application of a nonradioactive binding assay of oxidized low-density lipoprotein to macrophage scavenger receptors

2013 ◽  
Vol 54 (11) ◽  
pp. 3206-3214 ◽  
Author(s):  
Erica N. Montano ◽  
Agnès Boullier ◽  
Felicidad Almazan ◽  
Christoph J. Binder ◽  
Joseph L. Witztum ◽  
...  
Keyword(s):  
Binding Assay ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Scavenger Receptors ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

scholarly journals Binding and Uptake of Oxidized Low Density Lipoprotein(LDL) by Macrophage Scavenger Receptors Are Enhanced by Substrate-Bound Fibronectin.

1995 ◽  
Vol 18 (6) ◽  
pp. 802-809 ◽  
Author(s):  
Masatoshi BEPPU ◽  
Masachiyo HORA ◽  
Mitsuhiro WATANABE ◽  
Kiyomi KIKUGAWA
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Scavenger Receptors ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

scholarly journals BISPHOSPHONATES PREVENT OXIDIZED LOW-DENSITY LIPOPROTEIN-INDUCED EXPRESSION OF OSTEOGENIC MARKERS IN AORTIC VALVE MYOFIBROBLASTS

2010 ◽  
Vol 55 (10) ◽  
pp. A149.E1398 ◽  
Author(s):  
Sammy Elmariah ◽  
Giovanni Cimmino ◽  
Valentin Fuster ◽  
Juan J. Badimon
Keyword(s):  
Aortic Valve ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Induced Expression ◽  
Osteogenic Markers

3.P.149 Increased expression of scavenger receptors for oxidized low density lipoprotein in macrophage-derived foam cells during atherosclerosis

1997 ◽  
Vol 134 (1-2) ◽  
pp. 229-230
Author(s):  
H.E. de Vries ◽  
B. Buchner ◽  
Th.J.C. van Berkel ◽  
J. Kuiper
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Foam Cells ◽  
Scavenger Receptors ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

Oxidized low-density lipoprotein transforms aortic valve interstitial cells into an osteogenic phenotype implying its role in aortic stenosis

2011 ◽  
Vol 213 (3) ◽  
pp. S33
Author(s):  
Joon Ho Lee ◽  
Xianzhong Meng ◽  
T. Brett Reece ◽  
Michael J. Weyant ◽  
Joseph C. Cleveland ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Stenosis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Interstitial Cells ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Valve Interstitial Cells

scholarly journals Association of Low-Density Lipoprotein Cholesterol With Risk of Aortic Valve Stenosis in Familial Hypercholesterolemia

2019 ◽  
Vol 4 (11) ◽  
pp. 1156 ◽  
Author(s):  
Liv J. Mundal ◽  
Anders Hovland ◽  
Jannicke Igland ◽  
Marit B. Veierød ◽  
Kirsten B. Holven ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Familial Hypercholesterolemia ◽  
Aortic Valve Stenosis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

Effects of Soy Pinitol on the Pro-Inflammatory Cytokines and Scavenger Receptors in Oxidized Low-Density Lipoprotein-Treated THP-1 Macrophages

2007 ◽  
Vol 10 (4) ◽  
pp. 594-601 ◽  
Author(s):  
Myung-Sook Choi ◽  
Won-Ha Lee ◽  
Eun-Young Kwon ◽  
Mi Ae Kang ◽  
Mi-Kyung Lee ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Scavenger Receptors ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Pro Inflammatory Cytokines
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