Do anti-smooth muscle antibodies predict development of autoimmune hepatitis in patients with normal liver function? – A retrospective cohort review

2016 ◽  
Vol 15 (7) ◽  
pp. 668-672 ◽  
Author(s):  
Rebecca Healey ◽  
Lynsey Corless ◽  
Pavels Gordins ◽  
Stephen Holding
Keyword(s):  
Smooth Muscle ◽  
Liver Function ◽  
Autoimmune Hepatitis ◽  
Retrospective Cohort ◽  
Normal Liver ◽  
Normal Liver Function ◽  
Smooth Muscle Antibodies

F-actin reactive smooth muscle antibody in subjects with normal liver function

Pathology ◽  
2009 ◽  
Vol 41 (6) ◽  
pp. 572-575 ◽  
Author(s):  
Ban-Hock Toh ◽  
Roberta Taylor ◽  
Wendy Pollock
Keyword(s):  
Smooth Muscle ◽  
Liver Function ◽  
Normal Liver ◽  
Normal Liver Function ◽  
Smooth Muscle Antibody

scholarly journals Bosentan Inducing Autoimmune Hepatitis in a Patient with Idiopathic Pulmonary Arterial Hypertension

2018 ◽  
Vol 27 (1) ◽  
pp. 89-92 ◽  
Author(s):  
Alexandre De Araujo ◽  
Augusto Mantovani ◽  
Carlos Thadeu Schmidt Cerski ◽  
Antonio Barros Lopes ◽  
Luiza Cristina Bortoncello ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Arterial Hypertension ◽  
Liver Function ◽  
Autoimmune Hepatitis ◽  
Normal Liver ◽  
Idiopathic Pulmonary Arterial Hypertension ◽  
Rapid Progression ◽  
Normal Liver Function ◽  
Pulmonary Arterial ◽  
Idiopathic Pulmonary Hypertension

A 41-year-old woman diagnosed with idiopathic pulmonary hypertension presented symptoms despite the use of vasodilators, requiring treatment with bosentan. Previously, the patient had no signs of autoimmunity and had normal liver function. After three years of bosentan use, aminotransferase levels increased, without improvement after bosentan suspension, leading to complementary investigation. The diagnosis of autoimmune hepatitis was confirmed by biopsy, already in the stage of cirrhosis. In conclusion, in case of aminotransferase levels that remain persistently elevated, despite the reduction in doses and/or suspension of bosentan, autoimmune hepatitis must be investigated and treated urgently due to possibly rapid progression to cirrhosis.

Management of Obscurely Dilated Common Bile Duct with Normal Liver Function Tests: A Pragmatic Approach

2021 ◽  
Author(s):  
Sundeep Singh Saluja ◽  
Vaibhav Kumar Varshney ◽  
Vidya Sharada Bhat ◽  
Phani Kumar Nekarakanti ◽  
Asit Arora ◽  
...  
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Liver Function ◽  
Normal Liver ◽  
Liver Function Tests ◽  
Pragmatic Approach ◽  
Normal Liver Function ◽  
Function Tests

Persistently raised aspartate aminotransferase (AST) due to macro-AST in a rheumatology clinic

Diagnosis ◽  
2015 ◽  
Vol 2 (2) ◽  
pp. 137-140 ◽  
Author(s):  
Wycliffe Mbagaya ◽  
Joanne Foo ◽  
Ahai Luvai ◽  
Claire King ◽  
Sarah Mapplebeck ◽  
...  
Keyword(s):  
Liver Function ◽  
Aspartate Aminotransferase ◽  
Normal Liver ◽  
Abdominal Ultrasound ◽  
Liver Function Tests ◽  
Analytical Investigation ◽  
Normal Liver Function ◽  
Rheumatology Clinic ◽  
History Of ◽  
Liver Biopsies

AbstractMacrocomplexes between immunoglobins and aspartate aminotransferase (macro-AST) may result in persistently increased AST concentration. The presence of macro-AST in patients has been implicated in unnecessary investigations of abnormal liver function tests. We report the case of a 44-year-old female who presented to the rheumatology clinic with a 12-months’ history of constant widespread pain affecting her limbs and was found to have an elevated AST concentration. Further information from her GP revealed a 14-years’ history of elevated AST with otherwise normal liver function. Previous abdominal ultrasound and two liver biopsies carried out 2 years apart were normal. This prompted further analytical investigation by the biochemistry department which identified macro-AST as the cause. This case illustrates that persistently raised isolated AST concentration with no other abnormal indices may warrant macroenzyme analysis potentially avoiding unnecessary invasive investigations.

scholarly journals Mildly elevated succinylacetone and normal liver function in compound heterozygotes with pathogenic and pseudodeficient FAH alleles

2018 ◽  
Vol 14 ◽  
pp. 55-58 ◽  
Author(s):  
Hao Yang ◽  
Francis Rossignol ◽  
Denis Cyr ◽  
Rachel Laframboise ◽  
Shu Pei Wang ◽  
...  
Keyword(s):  
Liver Function ◽  
Normal Liver ◽  
Normal Liver Function ◽  
Compound Heterozygotes

Case 1.4

2014 ◽  
pp. 7-8
Author(s):  
Christine U. Lee ◽  
James F. Glockner
Keyword(s):  
Liver Function ◽  
Neutrophil Count ◽  
Laboratory Tests ◽  
Normal Liver ◽  
Normal Liver Function ◽  
Nonproductive Cough

67-year-old woman status post fundoplication 2 months ago, with development of fever and nonproductive cough shortly afterward; laboratory tests revealed normal liver function and an increased neutrophil count Coronal SSFSE image (Figure 1.4.1) and axial fat-suppressed T2-weighted FSE image (Figure 1.4.2...

Potential influence of the phthalates on normal liver function and cardiometabolic risk in males

2017 ◽  
Vol 190 (1) ◽  
Author(s):  
Nataša Milošević ◽  
Nataša Milić ◽  
Dragana Živanović Bosić ◽  
Ivana Bajkin ◽  
Ivanka Perčić ◽  
...  
Keyword(s):  
Liver Function ◽  
Cardiometabolic Risk ◽  
Normal Liver ◽  
Potential Influence ◽  
Normal Liver Function
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