scholarly journals A systematic review of decision-making impairments in Parkinson’s Disease: Dopaminergic medication and methodological variability

Basal Ganglia ◽  
2018 ◽  
Vol 14 ◽  
pp. 31-40 ◽  
Author(s):  
Sophie Wohlert Kjær ◽  
Malene Flensborg Damholdt ◽  
Mette Buhl Callesen
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Decision Making ◽  
Parkinson's Disease ◽  
Dopaminergic Medication

scholarly journals Dopaminergic drugs decrease loss aversion in Parkinson’s disease with but not without depression

2016 ◽  
Author(s):  
Monique H.M. Timmer ◽  
Guillaume Sescousse ◽  
Rianne A.J. Esselink ◽  
Payam Piray ◽  
Roshan Cools
Keyword(s):  
Parkinson’S Disease ◽  
Decision Making ◽  
Parkinson's Disease ◽  
Loss Aversion ◽  
Drug Effects ◽  
Risky Choice ◽  
Motor Symptom ◽  
Risky Decision ◽  
Dopaminergic Drugs ◽  
Dopaminergic Medication

AbstractDepression, a common non-motor symptom of Parkinson’s disease (PD), is accompanied by impaired decision making and an enhanced response to aversive outcomes. Current strategies to treat depression in PD include dopaminergic medication. However, their use can be accompanied by detrimental side effects, such as enhanced risky choice. The mechanisms underlying dopamine-induced increases in risky choice are unclear. In the current study we adopt a clinical-neuroeconomic approach to investigate the effects of dopaminergic medication on loss aversion during risky choice in depressed and non-depressed PD. Twenty-three healthy controls, 21 depressed and 22 non-depressed PD patients were assessed using a well-established gambling task measuring loss aversion during risky choice. Patients were tested on two occasions, after taking their normal dopaminergic medication (ON) and after withdrawal of their medication (OFF). Dopaminergic medication decreased loss aversion to a greater extent in depressed than non-depressed PD patients. Moreover, we show that the degree to which dopaminergic medication decreases loss aversion correlated with current depression severity and with drug effects on depression scores. These findings demonstrate that dopamine-induced changes in loss aversion depend on the presence of depressive symptoms in PD.Significance statementDopaminergic medication that is used to treat motor and non-motor symptoms in patients with Parkinson’s disease is known to contribute to risky decision-making. The underlying mechanisms are unclear. The present study demonstrates that dopaminergic medication in Parkinson’s disease decreases loss aversion during risky choice, but only in depressed and not in non-depressed patients with Parkinson’s disease. These results advance our understanding of the mechanisms underlying dopamine-induced risky choice, while also identifying depression as an important factor that confers vulnerability to such dopamine-induced risky choice.Conflict of InterestThe authors declare no competing financial interests.

scholarly journals The effects of dopaminergic medication on dynamic decision making in Parkinson's disease

2014 ◽  
Vol 53 ◽  
pp. 157-164 ◽  
Author(s):  
Magda Osman ◽  
Agata Ryterska ◽  
Kash Karimi ◽  
LingLing Tu ◽  
Ignacio Obeso ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Decision Making ◽  
Parkinson's Disease ◽  
Dynamic Decision Making ◽  
Dopaminergic Medication

scholarly journals Incentive-driven decision-making networks in de novo and drug-treated Parkinson's disease patients with impulsive-compulsive behaviors: A systematic review of neuroimaging studies

2020 ◽  
Vol 78 ◽  
pp. 165-177
Author(s):  
Alice Martini ◽  
Stefano Tamburin ◽  
Roberta Biundo ◽  
Luca Weis ◽  
Angelo Antonini ◽  
...  
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Decision Making ◽  
Parkinson's Disease ◽  
De Novo ◽  
Compulsive Behaviors

Different effects of dopaminergic medication on perceptual decision-making in Parkinson's disease as a function of task difficulty and speed–accuracy instructions

2015 ◽  
Vol 75 ◽  
pp. 577-587 ◽  
Author(s):  
Yu-Ting Huang ◽  
Dejan Georgiev ◽  
Tom Foltynie ◽  
Patricia Limousin ◽  
Maarten Speekenbrink ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Decision Making ◽  
Parkinson's Disease ◽  
Task Difficulty ◽  
Perceptual Decision Making ◽  
Perceptual Decision ◽  
Dopaminergic Medication ◽  
Speed Accuracy

Decision-making under risk is improved by both dopaminergic medication and subthalamic stimulation in Parkinson's disease

2014 ◽  
Vol 254 ◽  
pp. 70-77 ◽  
Author(s):  
Jana K. Boller ◽  
Michael T. Barbe ◽  
K. Amande M. Pauls ◽  
Christiane Reck ◽  
Matthias Brand ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Decision Making ◽  
Parkinson's Disease ◽  
Decision Making Under Risk ◽  
Dopaminergic Medication ◽  
Subthalamic Stimulation

scholarly journals The Profile of People with Parkinson’s Disease Included in Community Boxing Exercise Programs

2021 ◽  
Vol 5 (1) ◽  
pp. 5
Author(s):  
Josefa Domingos ◽  
Tamine Capato ◽  
Catarina Godinho
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Negative Impact ◽  
Patient Characteristics ◽  
Inclusion Criteria ◽  
Exercise Programs

Exercise is widely recommended for people with Parkinson (PD). Boxing is a popular mode of training. However, including individuals with less favorable profiles may have a negative impact on participation. We performed a systematic review to study the patient characteristics that were included in boxing exercise programs research and reflect on the possible inclusion criteria that professionals can use for boxing exercise programs. Indications for the best profiles were limited due to the small number of studies. Boxing programs should include people with the diagnosis of PD in earlier stages, independently ambulatory, and without current severe musculoskeletal or cardiovascular conditions.

scholarly journals Translating Evidence to Advanced Parkinson's Disease Patients: A Systematic Review and Meta‐Analysis

2021 ◽  
Author(s):  
Frouke A.P. Nijhuis ◽  
Rianne Esselink ◽  
Rob M.A. Bie ◽  
Hans Groenewoud ◽  
Bastiaan R. Bloem ◽  
...  
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Meta Analysis ◽  
Advanced Parkinson’S Disease

scholarly journals Quality of life in Parkinson's disease: A systematic review and meta‐analysis of comparative studies

2020 ◽  
Author(s):  
Na Zhao ◽  
Yuan Yang ◽  
Ling Zhang ◽  
Qinge Zhang ◽  
Lloyd Balbuena ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Comparative Studies ◽  
Meta Analysis
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