Different effects of dopaminergic medication on perceptual decision-making in Parkinson's disease as a function of task difficulty and speed–accuracy instructions

2015 ◽  
Vol 75 ◽  
pp. 577-587 ◽  
Author(s):  
Yu-Ting Huang ◽  
Dejan Georgiev ◽  
Tom Foltynie ◽  
Patricia Limousin ◽  
Maarten Speekenbrink ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Decision Making ◽  
Parkinson's Disease ◽  
Task Difficulty ◽  
Perceptual Decision Making ◽  
Perceptual Decision ◽  
Dopaminergic Medication ◽  
Speed Accuracy

Perceptual decision-making in patients with Parkinson’s disease

2014 ◽  
Vol 28 (12) ◽  
pp. 1149-1154 ◽  
Author(s):  
Atbin Djamshidian ◽  
Sean S O’Sullivan ◽  
Andrew D Lawrence ◽  
Thomas Foltynie ◽  
Iciar Aviles-Olmos ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Decision Making ◽  
Parkinson's Disease ◽  
Perceptual Decision Making ◽  
Perceptual Decision

scholarly journals Reduction of Influence of Task Difficulty on Perceptual Decision Making by STN Deep Brain Stimulation

2013 ◽  
Vol 23 (17) ◽  
pp. 1681-1684 ◽  
Author(s):  
Nikos Green ◽  
Rafal Bogacz ◽  
Julius Huebl ◽  
Ann-Kristin Beyer ◽  
Andrea A. Kühn ◽  
...  
Keyword(s):  
Decision Making ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Task Difficulty ◽  
Perceptual Decision Making ◽  
Perceptual Decision ◽  
Deep Brain

scholarly journals Dopaminergic drugs decrease loss aversion in Parkinson’s disease with but not without depression

2016 ◽  
Author(s):  
Monique H.M. Timmer ◽  
Guillaume Sescousse ◽  
Rianne A.J. Esselink ◽  
Payam Piray ◽  
Roshan Cools
Keyword(s):  
Parkinson’S Disease ◽  
Decision Making ◽  
Parkinson's Disease ◽  
Loss Aversion ◽  
Drug Effects ◽  
Risky Choice ◽  
Motor Symptom ◽  
Risky Decision ◽  
Dopaminergic Drugs ◽  
Dopaminergic Medication

AbstractDepression, a common non-motor symptom of Parkinson’s disease (PD), is accompanied by impaired decision making and an enhanced response to aversive outcomes. Current strategies to treat depression in PD include dopaminergic medication. However, their use can be accompanied by detrimental side effects, such as enhanced risky choice. The mechanisms underlying dopamine-induced increases in risky choice are unclear. In the current study we adopt a clinical-neuroeconomic approach to investigate the effects of dopaminergic medication on loss aversion during risky choice in depressed and non-depressed PD. Twenty-three healthy controls, 21 depressed and 22 non-depressed PD patients were assessed using a well-established gambling task measuring loss aversion during risky choice. Patients were tested on two occasions, after taking their normal dopaminergic medication (ON) and after withdrawal of their medication (OFF). Dopaminergic medication decreased loss aversion to a greater extent in depressed than non-depressed PD patients. Moreover, we show that the degree to which dopaminergic medication decreases loss aversion correlated with current depression severity and with drug effects on depression scores. These findings demonstrate that dopamine-induced changes in loss aversion depend on the presence of depressive symptoms in PD.Significance statementDopaminergic medication that is used to treat motor and non-motor symptoms in patients with Parkinson’s disease is known to contribute to risky decision-making. The underlying mechanisms are unclear. The present study demonstrates that dopaminergic medication in Parkinson’s disease decreases loss aversion during risky choice, but only in depressed and not in non-depressed patients with Parkinson’s disease. These results advance our understanding of the mechanisms underlying dopamine-induced risky choice, while also identifying depression as an important factor that confers vulnerability to such dopamine-induced risky choice.Conflict of InterestThe authors declare no competing financial interests.

scholarly journals The effects of dopaminergic medication on dynamic decision making in Parkinson's disease

2014 ◽  
Vol 53 ◽  
pp. 157-164 ◽  
Author(s):  
Magda Osman ◽  
Agata Ryterska ◽  
Kash Karimi ◽  
LingLing Tu ◽  
Ignacio Obeso ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Decision Making ◽  
Parkinson's Disease ◽  
Dynamic Decision Making ◽  
Dopaminergic Medication

scholarly journals Transcranial Direct Current Stimulation Does Not Influence the Speed–Accuracy Tradeoff in Perceptual Decision-making: Evidence from Three Independent Studies

2016 ◽  
Vol 28 (9) ◽  
pp. 1283-1294 ◽  
Author(s):  
Gilles de Hollander ◽  
Ludovica Labruna ◽  
Roberta Sellaro ◽  
Anne Trutti ◽  
Lorenza S. Colzato ◽  
...  
Keyword(s):  
Decision Making ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Response Threshold ◽  
Perceptual Decision Making ◽  
Perceptual Decision ◽  
Direct Current Stimulation ◽  
Speed Accuracy ◽  
Accuracy Tradeoff

In perceptual decision-making tasks, people balance the speed and accuracy with which they make their decisions by modulating a response threshold. Neuroimaging studies suggest that this speed–accuracy tradeoff is implemented in a corticobasal ganglia network that includes an important contribution from the pre-SMA. To test this hypothesis, we used anodal transcranial direct current stimulation (tDCS) to modulate neural activity in pre-SMA while participants performed a simple perceptual decision-making task. Participants viewed a pattern of moving dots and judged the direction of the global motion. In separate trials, they were cued to either respond quickly or accurately. We used the diffusion decision model to estimate the response threshold parameter, comparing conditions in which participants received sham or anodal tDCS. In three independent experiments, we failed to observe an influence of tDCS on the response threshold. Additional, exploratory analyses showed no influence of tDCS on the duration of nondecision processes or on the efficiency of information processing. Taken together, these findings provide a cautionary note, either concerning the causal role of pre-SMA in decision-making or on the utility of tDCS for modifying response caution in decision-making tasks.

scholarly journals Age Affects How Task Difficulty and Complexity Modulate Perceptual Decision-Making

2019 ◽  
Vol 11 ◽  
Author(s):  
Claudine Habak ◽  
Mohamed L. Seghier ◽  
Julie Brûlé ◽  
Mohamed A. Fahim ◽  
Oury Monchi
Keyword(s):  
Decision Making ◽  
Task Difficulty ◽  
Perceptual Decision Making ◽  
Perceptual Decision
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