The BACE1 inhibitor LY2886721 improves diabetic phenotypes of BACE1 knock-in mice

2021 ◽  
pp. 166149
Author(s):  
Ruta Dekeryte ◽  
Zara Franklin ◽  
Claire Hull ◽  
Lorenzo Croce ◽  
Sarah Kamli-Salino ◽  
...  
Keyword(s):  
Bace1 Inhibitor

Water-soluble chitosan derivatives as a BACE1 inhibitor

2005 ◽  
Vol 13 (23) ◽  
pp. 6551-6555 ◽  
Author(s):  
Jae-Young Je ◽  
Se-Kwon Kim
Keyword(s):  
Water Soluble ◽  
Chitosan Derivatives ◽  
Bace1 Inhibitor

scholarly journals 2,2′,4′-Trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice

2010 ◽  
Vol 114 (2) ◽  
pp. 374-385 ◽  
Author(s):  
Zhiyuan Zhu ◽  
Chenjing Li ◽  
Xu Wang ◽  
Zhengyi Yang ◽  
Jing Chen ◽  
...  
Keyword(s):  
Memory Impairment ◽  
Glycyrrhiza Glabra ◽  
Bace1 Inhibitor

BACE1 Inhibitor Lanabecestat (AZD3293) in a Phase 1 Study of Healthy Japanese Subjects: Pharmacokinetics and Effects on Plasma and Cerebrospinal Fluid Aβ Peptides

2017 ◽  
Vol 57 (11) ◽  
pp. 1460-1471 ◽  
Author(s):  
Kei Sakamoto ◽  
Shunji Matsuki ◽  
Kyoko Matsuguma ◽  
Tatsuya Yoshihara ◽  
Naoki Uchida ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Phase 1 ◽  
Phase 1 Study ◽  
Aβ Peptides ◽  
Bace1 Inhibitor ◽  
Japanese Subjects

scholarly journals Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

2012 ◽  
Vol 287 (49) ◽  
pp. 41245-41257 ◽  
Author(s):  
Fredrik Jeppsson ◽  
Susanna Eketjäll ◽  
Juliette Janson ◽  
Sofia Karlström ◽  
Susanne Gustavsson ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Bace1 Inhibitor ◽  
Clinical Candidate

O1-04-02: Significant Aβ lowering in CSF and plasma after oral administration of a potent small molecule BACE1 inhibitor in non-human primates

2008 ◽  
Vol 4 ◽  
pp. T114-T115
Author(s):  
Adam J. Simon ◽  
Marie Holihan ◽  
Guoxin Wu ◽  
Maria Michener ◽  
Diane Posavec ◽  
...  
Keyword(s):  
Oral Administration ◽  
Small Molecule ◽  
Bace1 Inhibitor

Synthesis of a BACE1 Inhibitor

Synfacts ◽  
2016 ◽  
Vol 12 (07) ◽  
pp. 0663-0663
Keyword(s):  
Bace1 Inhibitor
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