Discovery and Chemical Development of Verubecestat, a BACE1 Inhibitor for the Treatment of Alzheimer’s Disease

2018 ◽  
pp. 53-89
Author(s):  
David A. Thaisrivongs ◽  
William J. Morris ◽  
Jack D. Scott
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Bace1 Inhibitor

scholarly journals In Silico Study of Centella asiatica Active Compound as BACE1 Inhibitor in Alzheimer’s Disease

JSMARTech ◽  
2020 ◽  
Vol 1 (2) ◽  
pp. 36-40
Author(s):  
Nala Mawaddani ◽  
◽  
Natalia RK Wibowo ◽  
Qumaira HH Nadhira ◽  
Ratih Ayu Pramifta ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Active Compound ◽  
In Silico ◽  
Centella Asiatica ◽  
Bace1 Inhibitor ◽  
In Silico Study

scholarly journals P1-044: Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of LY3202626, a Novel Bace1 Inhibitor, in Healthy Subjects and Patients with Alzheimer’s Disease

2016 ◽  
Vol 12 ◽  
pp. P418-P418
Author(s):  
Brian A. Willis ◽  
Stephen L. Lowe ◽  
Leslie L. Daugherty ◽  
Robert A. Dean ◽  
Brett English ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Healthy Subjects ◽  
Bace1 Inhibitor

Synthesis of Verubecestat, a BACE1 Inhibitor for the Treatment of Alzheimer’s Disease

2016 ◽  
Vol 18 (22) ◽  
pp. 5780-5783 ◽  
Author(s):  
David A. Thaisrivongs ◽  
Steven P. Miller ◽  
Carmela Molinaro ◽  
Qinghao Chen ◽  
Zhiguo J. Song ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Bace1 Inhibitor

The Selective BACE1 Inhibitor VIa Reduces Amyloid-β Production in Cell and Mouse Models of Alzheimer's Disease

2013 ◽  
Vol 37 (4) ◽  
pp. 823-834 ◽  
Author(s):  
Xiaorui Cheng ◽  
Yu Zhou ◽  
Wei Gu ◽  
Jie Wu ◽  
Aihua Nie ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Amyloid Β ◽  
Bace1 Inhibitor

O5-03-04: G-Secretase Modulator Enhances the Ab-Lowering Effect of Bace1 Inhibitor in Mouse Models of Alzheimer’s Disease

2016 ◽  
Vol 12 ◽  
pp. P383-P384
Author(s):  
Tatiana Melnikova ◽  
Rishab Shyam ◽  
Stephanie Porter ◽  
Kate LaClair ◽  
DaMin Park ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Bace1 Inhibitor ◽  
Lowering Effect
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