Stimulation of ribosomal RNA gene promoter by transcription factor Sp1 involves active DNA demethylation by Gadd45-NER pathway

2016 ◽  
Vol 1859 (8) ◽  
pp. 953-963 ◽  
Author(s):  
Pallavi Rajput ◽  
Vijaya Pandey ◽  
Vijay Kumar
Keyword(s):  
Transcription Factor ◽  
Ribosomal Rna ◽  
Gene Promoter ◽  
Dna Demethylation ◽  
Ribosomal Rna Gene ◽  
Active Dna Demethylation ◽  
Transcription Factor Sp1 ◽  
Stimulation Of

Thioredoxin-mediated redox control of the transcription factor Sp1 and regulation of the thioredoxin gene promoter

Gene ◽  
2003 ◽  
Vol 319 ◽  
pp. 107-116 ◽  
Author(s):  
Kelly L Bloomfield ◽  
Simone A Osborne ◽  
Derek D Kennedy ◽  
Frank M Clarke ◽  
Kathryn F Tonissen
Keyword(s):  
Transcription Factor ◽  
Gene Promoter ◽  
Redox Control ◽  
Transcription Factor Sp1

Transcription of the mouse secretory protease inhibitor p12 gene is activated by the developmentally regulated positive transcription factor Sp1

1992 ◽  
Vol 12 (9) ◽  
pp. 3796-3806
Author(s):  
S Robidoux ◽  
P Gosselin ◽  
M Harvey ◽  
S Leclerc ◽  
S L Guérin
Keyword(s):  
Transcription Factor ◽  
Mutational Analysis ◽  
Dimethyl Sulfate ◽  
Gene Promoter ◽  
Binding Activity ◽  
Regulatory Sequence ◽  
Culture Cells ◽  
Transcription Factor Sp1 ◽  
Nuclear Extracts ◽  
Mouse Tissues

We have previously shown that a trans-acting protein produced in some tissue culture cells positively control the transcriptional activity directed by the mouse p12 promoter. This nuclear protein exerts its positive activity by interacting with a regulatory sequence designated p12.A and located between the TATA and CCAAT box elements on the p12 gene promoter. Using DNase I and dimethyl sulfate methylation interference footprinting techniques coupled with gel retardation assays, we found evidence that the protein which binds to the p12.A element is the well-known transcription factor Sp1. Mutational analysis in transient transfection assays confirmed the positive activity exerted by this protein in every cell line tested. In agreement with this observation, we detected a p12.A-Sp1 binding activity in nuclear extracts prepared from all cell lines used. However, a similar binding activity could not be detected in a number of nuclear extracts prepared from normal mouse tissues. In this report, we provide the evidence that the lack of Sp1-binding activity results from the degradation of Sp1 in the kidney, liver, and pancreas of the mouse.

Characterization of the human SLC22A18 gene promoter and its regulation by the transcription factor Sp1

Gene ◽  
2009 ◽  
Vol 429 (1-2) ◽  
pp. 37-43 ◽  
Author(s):  
Abdullah Mahmood Ali ◽  
Vineeta Bajaj ◽  
K.S. Gopinath ◽  
Arun Kumar
Keyword(s):  
Transcription Factor ◽  
Gene Promoter ◽  
Transcription Factor Sp1

scholarly journals Methylation of the ribosomal RNA gene promoter is associated with aging and age-related decline

Aging Cell ◽  
2017 ◽  
Vol 16 (5) ◽  
pp. 966-975 ◽  
Author(s):  
Patrizia D'Aquila ◽  
Alberto Montesanto ◽  
Maurizio Mandalà ◽  
Sabrina Garasto ◽  
Vincenzo Mari ◽  
...  
Keyword(s):  
Ribosomal Rna ◽  
Gene Promoter ◽  
Ribosomal Rna Gene ◽  
Age Related

The binding of a transcription factor to deletion mutants of a 5S ribosomal RNA gene

Cell ◽  
1981 ◽  
Vol 23 (3) ◽  
pp. 665-669 ◽  
Author(s):  
Shigeru Sakonju ◽  
Donald D. Brown ◽  
David Engelke ◽  
Sun-Yu Ng ◽  
B.S. Shastry ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Ribosomal Rna ◽  
Deletion Mutants ◽  
Ribosomal Rna Gene ◽  
5S Ribosomal Rna

scholarly journals A ribosomal RNA gene promoter at the telomere of a mini-chromosome inTrypanosoma brucei

1992 ◽  
Vol 20 (11) ◽  
pp. 2725-2734 ◽  
Author(s):  
Joost C.B.M. Zomerdijk ◽  
Rudo Kieft ◽  
Piet Borst
Keyword(s):  
Ribosomal Rna ◽  
Gene Promoter ◽  
Ribosomal Rna Gene
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