transcription initiation site
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2016 ◽  
Vol 45 (7) ◽  
pp. 4036-4050 ◽  
Author(s):  
Elena Herrera-Carrillo ◽  
Zong-liang Gao ◽  
Alex Harwig ◽  
Matthias T. Heemskerk ◽  
Ben Berkhout


RNA ◽  
2016 ◽  
Vol 22 (11) ◽  
pp. 1689-1698 ◽  
Author(s):  
Aaron Coey ◽  
Kevin Larsen ◽  
Joseph D. Puglisi ◽  
Elisabetta Viani Puglisi


2016 ◽  
Vol 36 (6) ◽  
pp. 992-1006 ◽  
Author(s):  
Bhawana Uprety ◽  
Amala Kaja ◽  
Jannatul Ferdoush ◽  
Rwik Sen ◽  
Sukesh R. Bhaumik

NuA4 histone lysine (K) acetyltransferase (KAT) promotes transcriptional initiation of TATA-binding protein (TBP)-associated factor (TAF)-dependent ribosomal protein genes. TAFs have also been recently found to enhance antisense transcription from the 3′ end of theGAL10coding sequence. However, it remains unknown whether, like sense transcription of the ribosomal protein genes, TAF-dependent antisense transcription ofGAL10also requires NuA4 KAT. Here, we show that NuA4 KAT associates with theGAL10antisense transcription initiation site at the 3′ end of the coding sequence. Such association of NuA4 KAT depends on the Reb1p-binding site that recruits Reb1p activator to theGAL10antisense transcription initiation site. Targeted recruitment of NuA4 KAT to theGAL10antisense transcription initiation site promotesGAL10antisense transcription. Like NuA4 KAT, histone H3 K4/36 methyltransferases and histone H2B ubiquitin conjugase facilitateGAL10antisense transcription, while the Swi/Snf and SAGA chromatin remodeling/modification factors are dispensable for antisense, but not sense, transcription ofGAL10. Taken together, our results demonstrate for the first time the roles of NuA4 KAT and other chromatin regulatory factors in controlling antisense transcription, thus illuminating chromatin regulation of antisense transcription.



2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Takao Masuda ◽  
Yoko Sato ◽  
Yu-Lun Huang ◽  
Satoshi Koi ◽  
Tatsuro Takahata ◽  
...  


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