Optimizing Photoperiod Switch to Maximize Floral Biomass and Cannabinoid Yield in Cannabis sativa L.: A Meta-Analytic Quantile Regression Approach

Cannabis sativa L. is an annual, short-day plant, such that long-day lighting promotes vegetative growth while short-day lighting induces flowering. To date, there has been no substantial investigation on how the switch between these photoperiods influences yield of C. sativa despite the tight correlation that plant size and floral biomass have with the timing of photoperiod switches in indoor growing facilities worldwide. Moreover, there are only casual predictions around how the timing of the photoperiodic switch may affect the production of secondary metabolites, like cannabinoids. Here we use a meta-analytic approach to determine when growers should switch photoperiods to optimize C. sativa floral biomass and cannabinoid content. To this end, we searched through ISI Web of Science for peer-reviewed publications of C. sativa that reported experimental photoperiod durations and results containing cannabinoid concentrations and/or floral biomass, then from 26 studies, we estimated the relationship between photoperiod and yield using quantile regression. Floral biomass was maximized when the long daylength photoperiod was minimized (i.e., 14 days), while THC and CBD potency was maximized under long day length photoperiod for ~42 and 49–50 days, respectively. Our work reveals a yield trade-off in C. sativa between cannabinoid concentration and floral biomass where more time spent under long-day lighting maximizes cannabinoid content and less time spent under long-day lighting maximizes floral biomass. Growers should carefully consider the length of long-day lighting exposure as it can be used as a tool to maximize desired yield outcomes.

Advances in Drugs Targeting Lymphangiogenesis for Preventing Tumor Progression and Metastasis

Metastasis of cancer cells from the primary tumor to other organs and tissues in the body is the leading cause of death in patients with malignancies. One of the principal ways cancer cells travel is through lymphatic vessels, and tumor invasion into the regional lymph nodes is a hallmark of early metastasis; thus, the formation of especially peritumoral lymphatic vessels is essential for tumor transportation that gives rise to further progression. In the past few decades, tumor-induced lymphangiogenesis has been testified to its tight correlation with lymphatic metastasis and poor clinical outcomes in multiple types of human malignancies, which warrants novel potential therapeutic targets for cancer treatment. As the understanding of underlying molecular mechanisms has grown tremendously over the years, an inexorable march of anti-lymphangiogenic therapy also aroused terrific interest. As a result, a great number of drugs have entered clinical trials, and some of them exhibited predominant contributions in cancer management. Herein, this review provides an updated summary of the current advances in therapies preventing lymphatic metastasis and discusses the validity of different applications.

What should we do about the employment of women with children in Russia? The role of preschool educational institutions

The paper examines the opportunities and obstacles to increasing the employment of women with children in Russia. There is a tight correlation between Russia’s lagging behind in the share of working women with children under the age of three and a lack of supply of preschool and childcare institutions. Using quantitative analysis of the Russian regions, we show that the expansion of the supply of preschool education services is associated with an increase in the employment of women, and the cost of introducing additional places in preschool organizations is recouped by additional tax revenues from working women with children in two years. Our cross-country analysis shows that the transition from traditional gender and social roles to more equal ones, the reduction of gender inequality, the encouragement of fathers to take parental leave, and the increased availability of part-time or flexible-schedule employment for women with children could further facilitate the employment of women with children. Our estimates show that an increase of preschool enrollment in Russia to the level of European countries would materialize a sizable economic growth potential: an increase in income per capita would be 3.5%.

What should we do about the employment of women with children in Russia? The role of preschool educational institutions

The paper examines the opportunities and obstacles to increasing the employment of women with children in Russia. There is a tight correlation between Russia’s lagging behind in the share of working women with children under the age of three and a lack of supply of preschool and childcare institutions. Using quantitative analysis of the Russian regions, we show that the expansion of the supply of preschool education services is associated with an increase in the employment of women, and the cost of introducing additional places in preschool organizations is recouped by additional tax revenues from working women with children in two years. Our cross-country analysis shows that the transition from traditional gender and social roles to more equal ones, the reduction of gender inequality, the encouragement of fathers to take parental leave, and the increased availability of part-time or flexible-schedule employment for women with children could further facilitate the employment of women with children. Our estimates show that an increase of preschool enrollment in Russia to the level of European countries would materialize a sizable economic growth potential: an increase in income per capita would be 3.5%.

Radio continuum properties of OH megamaser galaxies

We present a study of the radio continuum properties of two luminous/ultraluminous infrared galaxy samples: the OH megamaser (OHM) sample (74 objects) and the control sample (128 objects) without detected maser emission. We carried out pilot observations for 140 objects with the radio telescope RATAN-600 at 1.2, 2.3, 4.7, 8.2, 11.2, and 22.3 GHz in 2019–2021. The OHM sample has two times more flat-spectrum sources (32 per cent) than the control sample. Steep radio spectra prevail in both samples. The median spectral index at 4.7 GHz α4.7 = −0.59 for the OHM sample, and α4.7 = −0.71 for the non-OHM galaxies. We confirm a tight correlation of the far-infrared (FIR) and radio luminosities for the OHM sample. We found correlations between isotropic OH line luminosity LOH and the spectral index α4.7 (ρ=0.26, p-val.=0.04) and between LOH and radio luminosity P1.4 (ρ=0.35, p-val.=0.005). Reviewing subsamples of masers powered by active galactic nuclei and star formation revealed insignificant differences for their FIR and radio properties. Nonetheless, AGN-powered galaxies exhibit larger scatter in a range of parameters and their standard deviations. The similarities in the radio and FIR properties in the two samples are presumably caused by the presence of a significant amount of AGN sources in both samples (47 and 30 per cent in the OHM and control samples) and/or possibly by the presence of undetected OH emission sources in the control sample.

Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis

The recent increases in cancer incidences have been linked to lifestyle changes that result in obesity and metabolic syndrome. It is now evident that these trends are associated with the profound changes that occur in the intestinal microbiome, producing altered microbial population signatures that interact, directly or indirectly, with potentially pro-carcinogenic molecular pathways of transcription, proliferation, and inflammation. The effects of the entire gut microbial population on overall health are complex, but individual bacteria are known to play important and definable roles. Recent detailed examinations of a large number of subjects show a tight correlation between habitual diets, fecal microbiome signatures, and markers of metabolic health. Diets that score higher in healthfulness or diversity such as plant-based diets, have altered ratios of specific bacteria, including an increase in short-chain fatty acid producers, which in turn have been linked to improved metabolic markers and lowered cancer risk. Contrarily, numerous studies have implicated less healthy, lower-scoring diets such as the Western diet with reduced intestinal epithelial defenses and promotion of specific bacteria that affect carcinogenic pathways. In this review, we will describe how different dietary patterns affect microbial populations in the gut and illustrate the subsequent impact of bacterial products and metabolites on molecular pathways of cancer development, both locally in the gut and systemically in distant organs.

Features of a negative ionization wave development preceding the full breakdown in a long capillary tube wrapped with a continuous or fine-sectioned grounded electrode

The experimental results on the study of negative ionization wave propagating along a long capillary tube are presented. The ionization wave was initiated by high-voltage pulse of negative polarity. The propagation of this surface ionization wave precedes and influences the establishment of complete electric breakdown within the tube. The spreading of this wave is accompanied by the surface charge deposition. The usage of the fine-sectioned outer electrode allows one to find out the general features of a negative ionization wave. The main of them is the tight correlation between local currents determining the formation of local surface charge and visual discharge images taken by the fast camera characterizing the pace of the ionization wave propagation.

Gut-Liver Immune Traffic: Deciphering Immune-Pathogenesis to Underpin Translational Therapy

The tight relationship between the gut and liver on embryological, anatomical and physiological levels inspired the concept of a gut-liver axis as a central element in the pathogenesis of gut-liver axis diseases. This axis refers to the reciprocal regulation between these two organs causing an integrated system of immune homeostasis or tolerance breakdown guided by the microbiota, the diet, genetic background, and environmental factors. Continuous exposure of gut microbiome, various hormones, drugs and toxins, or metabolites from the diet through the portal vein adapt the liver to maintain its tolerogenic state. This is orchestrated by the combined effort of immune cells network: behaving as a sinusoidal and biliary firewall, along with a regulatory network of immune cells including, regulatory T cells and tolerogenic dendritic cells (DC). In addition, downregulation of costimulatory molecules on hepatic sinusoids, hepatocytes and biliary epithelial cells as well as regulating the bile acids chain also play a part in hepatic immune homeostasis. Recent evidence also demonstrated the link between changes in the gut microbiome and liver resident immune cells in the progression of cirrhosis and the tight correlation among primary sclerosing cholangitis (PSC) and also checkpoint induced liver and gut injury. In this review, we will summarize the most recent evidence of the bidirectional relationship among the gut and the liver and how it contributes to liver disease, focusing mainly on PSC and checkpoint induced hepatitis and colitis. We will also focus on completed therapeutic options and on potential targets for future treatment linking with immunology and describe the future direction of this research, taking advantage of modern technologies.

Decreased piRNAs in Infertile Semen Are Related to Downregulation of Sperm MitoPLD Expression

Currently, the molecular mechanisms underlining male infertility are still poorly understood. Our previous study has demonstrated that PIWI-interacting RNAs (piRNAs) are downregulated in seminal plasma of infertile patients and can serve as molecular biomarkers for male infertility. However, the source and mechanism for the dysregulation of piRNAs remain obscure. In this study, we found that exosomes are present in high concentrations in human seminal plasma and confirmed that piRNAs are predominantly present in the exosomal fraction of seminal plasma. Moreover, we showed that piRNAs were significantly decreased in exosomes of asthenozoospermia patients compared with normozoospermic men. By systematically screening piRNA profiles in sperms of normozoospermic men and asthenozoospermia patients, we found that piRNAs were parallelly reduced during infertility. At last, we investigated the expression of some proteins that are essential for piRNAs biogenesis in sperms and therefore identified a tight correlation between the levels of spermatozoa piRNA and MitoPLD protein, suggesting that the loss-of-function of MitoPLD could cause a severe defect of piRNA accumulation in sperms. In summary, this study identified a parallel reduction of piRNAs and MitoPLD protein in sperms of asthenozoospermia patients, which may provide pathophysiological clues about sperm motility.

Fictive Deixis, Direct Discourse, and Viewpoint Networks

This paper proposes a renewed and more textured understanding of the relation between deixis and direct discourse, grounded in a broader range of genres and reflecting contemporary multimodal usage. I re-consider the phenomena covered by the concept of deixis in connection to the speech situation, and, by extension, to the category of Direct Discourse, in its various functions. I propose an understanding of Direct Discourse as a construction which is a correlate of Deictic Ground. Relying on Mental Spaces Theory and the apparatus it makes available for a close analysis of viewpoint networks, I analyze examples from a range of discourse genres - textual, visual and multimodal, such as literature, political campaigns, internet memes and storefront signs. These discourse contexts use Direct Discourse Constructions but usually lack a fully profiled Deictic Ground. I propose that in such cases the Deictic Ground is not a pre-existing conceptual structure, but rather is set up ad hoc to construe non-standard uses of Direct Discourse–I refer to such construals as Fictive Deictic Grounds. In that context, I propose a re-consideration of the concept of Direct Discourse, to explain its tight correlation with the concept of deixis. I also argue for a treatment of Deictic Ground as a composite structure, which may not be fully profiled in each case, while participating in the construction of viewpoint configurations.