Ultraviolet radiation-induced apoptosis in keratinocytes: On the role of cytosolic factors

2005 ◽  
Vol 1755 (2) ◽  
pp. 90-106 ◽  
Author(s):  
Zerihun Assefa ◽  
An Van Laethem ◽  
Marjan Garmyn ◽  
Patrizia Agostinis
Keyword(s):  
Ultraviolet Radiation ◽  
Radiation Induced ◽  
Induced Apoptosis ◽  
Cytosolic Factors

scholarly journals α-Melanocyte-stimulating Hormone Protects from Ultraviolet Radiation-induced Apoptosis and DNA Damage

2004 ◽  
Vol 280 (7) ◽  
pp. 5795-5802 ◽  
Author(s):  
Markus Böhm ◽  
Ilka Wolff ◽  
Thomas E. Scholzen ◽  
Samantha J. Robinson ◽  
Eugene Healy ◽  
...  
Keyword(s):  
Dna Damage ◽  
Ultraviolet Radiation ◽  
Melanocyte Stimulating Hormone ◽  
Radiation Induced ◽  
Induced Apoptosis ◽  
Stimulating Hormone

The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis

1998 ◽  
Vol 47 (3) ◽  
pp. 225-232 ◽  
Author(s):  
Marcel Verheij ◽  
Gerald A Ruiter ◽  
Shuraila F Zerp ◽  
Wim J van Blitterswijk ◽  
Zvi Fuks ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Signaling Pathway ◽  
Jnk Signaling ◽  
Radiation Induced ◽  
Jnk Signaling Pathway ◽  
Induced Apoptosis

scholarly journals Bax deficiency affects caspase-2 activation during ultraviolet radiation-induced apoptosis

Oncogene ◽  
2003 ◽  
Vol 23 (6) ◽  
pp. 1321-1325 ◽  
Author(s):  
Qin He ◽  
Ying Huang ◽  
M Saeed Sheikh
Keyword(s):  
Ultraviolet Radiation ◽  
Radiation Induced ◽  
Caspase 2 ◽  
Induced Apoptosis

scholarly journals DR5 Knockout Mice Are Compromised in Radiation-Induced Apoptosis

2005 ◽  
Vol 25 (5) ◽  
pp. 2000-2013 ◽  
Author(s):  
Niklas Finnberg ◽  
Joshua J. Gruber ◽  
Peiwen Fei ◽  
Dorothea Rudolph ◽  
Anka Bric ◽  
...  
Keyword(s):  
Cell Death ◽  
Null Mouse ◽  
Organ Specific ◽  
Radiation Induced ◽  
Induced Apoptosis ◽  
The Brain ◽  
Necrosis Factor

ABSTRACT DR5 (also called TRAIL receptor 2 and KILLER) is an apoptosis-inducing membrane receptor for tumor necrosis factor-related apoptosis-inducing ligand (also called TRAIL and Apo2 ligand). DR5 is a transcriptional target of p53, and its overexpression induces cell death in vitro. However, the in vivo biology of DR5 has remained largely unexplored. To better understand the role of DR5 in development and in adult tissues, we have created a knockout mouse lacking DR5. This mouse is viable and develops normally with the exception of having an enlarged thymus. We show that DR5 is not expressed in developing embryos but is present in the decidua and chorion early in development. DR5-null mouse embryo fibroblasts expressing E1A are resistant to treatment with TRAIL, suggesting that DR5 may be the primary proapoptotic receptor for TRAIL in the mouse. When exposed to ionizing radiation, DR5-null tissues exhibit reduced amounts of apoptosis compared to wild-type thymus, spleen, Peyer's patches, and the white matter of the brain. In the ileum, colon, and stomach, DR5 deficiency was associated with a subtle phenotype of radiation-induced cell death. These results indicate that DR5 has a limited role during embryogenesis and early stages of development but plays an organ-specific role in the response to DNA-damaging stimuli.

Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair

2001 ◽  
Vol 4 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Agatha Schwarz ◽  
Sonja Ständer ◽  
Mark Berneburg ◽  
Markus Böhm ◽  
Dagmar Kulms ◽  
...  
Keyword(s):  
Dna Repair ◽  
Ultraviolet Radiation ◽  
Interleukin 12 ◽  
Radiation Induced ◽  
Induced Apoptosis
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