#15 Endocrine and immune responses to stress in chronic inflammatory skin disorders ñ a comparison between TH1 (psoriasis vulgaris) and TH2 (atopic dermatitis) mediated skin disease

2005 ◽  
Vol 19 (4) ◽  
pp. e8
Author(s):  
Angelika Buske-Kirschbaum ◽  
Simone Kern ◽  
Marcel Ebrecht ◽  
Dirk Hellhammer
Author(s):  
Ben Esdaile

Psoriasis is a common, chronic inflammatory skin disease that is associated with joint disease in approximately 25% of patients. The most common variant of psoriasis is chronic plaque psoriasis (psoriasis vulgaris), which has the hallmark of well-demarcated erythematous plaques covered by silvery scale. There are a number of other variants of psoriasis, including guttate, inverse, palmoplantar, flexural, pustular, and erythrodermic.


2001 ◽  
Vol 81 (7) ◽  
pp. 969-976 ◽  
Author(s):  
Michael Allen ◽  
Akemi Ishida-Yamamoto ◽  
John McGrath ◽  
Simon Davison ◽  
Hajime Iizuka ◽  
...  

Author(s):  
Sangeeta Huidrom

: Pediatric atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease affecting 20% of children all over the world especially in developed countries. Recently, there is an increase in the prevalence rate of AD. This chronic inflammatory skin disease causes economic and social burden to the family. The exact cause of AD is not known, however recent studies suggest that imbalance of microflora present in the gut leads to AD. The current treatment of AD involves the application of moisturizer, topical corticosteroids, antihistamines and antibiotics. This line of treatment of AD in children has many side effects. An alternative novel therapeutic approached have to be explored to combat this chronic skin disease. In recent years there is increasing interest in the use of probiotic in the modulation of gut microbiota for the management of AD. Many research studies showed that administration of probiotic give positive results in the prevention and treatment of AD in children, however, the results are not consistent and conclusive. In this review, the dysbiosis of the gut flora contributes to the development of AD is addressed and clinical evidence of probiotics in the prevention and treatment of AD children is also summarises.


2012 ◽  
Vol 9 (2) ◽  
pp. 35-44
Author(s):  
D Sh Macharadze

Atopic dermatitis (AD) — a chronic inflammatory skin disease with a broad spectrum of clinical symptoms. It is diagnosed mainly clinically. Sensitization to inhalled and food allergens may play a role in the development of AD. Thus, it is important to determine the presence of sensitization for environmental control and allergen avoidance, pharmacotherapy, and immunotherapy.


Author(s):  
Dr. Subhash B. Jamdhade ◽  
Namrata kende ◽  
Dr. S. K. Jaiswal ◽  
Dr. Pradnya. S. Jamdhade

ABSTRACT In ayurveda all skin diseases describes under the heading of kushta .  "Kushnatee iti kushtham."       ( Ma.Ni/kushta/Tika 1) The disease that destroyes the affected part of skin . Both charak samhita and sushrut samhita  classify skin disease into 2 categories . 1) Mahakushtha (major) 2) Kshudrakushtha (minor)                                               ....... Ch.ni 5/4 Ayurvedically, Eczema is considered to be a type of kushtha. i. e.type of kushdrakushtha which is disease of the skin .It is also known as a type of twak roga .which also signifies that it is a skin disease that twak translates to skin and rog translates to pain . Vicharchika is characterised by the following symptoms ati kandu ,bahu strav ,rukshta ,shyavata ,pidika,raji. As described in terms od nidan ,purvarupa,samprapti and chikitsa vicharchika can most certainly be corelated with the modern interpretation of eczema or atopic dermatitis .Eczema or atopic dermatitis is chronic inflammatory skin condition. Atopic dermatitis is characterised by  cracked or scaly skin discolored patches,erythma(red skin),papules, exudate(oozing) and intence pruritus (itching ).


2018 ◽  
pp. 122-127 ◽  
Author(s):  
E. I. Danilova ◽  
O. Yu. Trusova ◽  
V. V. Sumenko

Atopic dermatitis (AtD) is a chronic inflammatory skin disease with complex etiopathogenesis, which begins in childhood. Purpose of the study: To evaluate the clinical efficacy and safety of Skin-cap cream as a topical background therapy in children with diabetes. Materials and methods: The study included 77 children aged 1 to 11 years with moderately severe AtD with a widespread lesion of the skin (33,5%), skin itching, inflammatory skin reaction and exacerbations occurring 3 to 4 times a year. During the study, two arms of children were formed: the treatment arm - 39 children with an average course of the disease (SCORAD index = 33,9 ± 2,2 points), who received the background therapy with the prescription of Skin-cap cream. Comparison arm: 38 children (SCORAD index = 34,2 ± 2,1 points), who received Afloderm cream as a background therapy. Results: Patients of the treatment arm showed a significant dynamics of relief of AtD symptoms as compared with the comparison arm. the differences in the duration of dermal manifestations were as follows: in the treatment arm, the time of reducing hyperaemia was 4,4 ± 1,2 days, in the comparison arm, hyperaemia was reduced at 5,7 ± 1,5 days (p< 0.05), the mean duration of alleviation of the skin itching was 3,0 ± 0,9 days and 5,8 ± 1,4 days (p< 0,05) at 6,8 and 7,3 days in the treatment arm and the comparison arm, respectively. Conclusions: The conducted study confirmed the high efficacy of the use of Skin-cap cream as a topical agent for background therapy of AtD, as compared to topical glucocorticosteroids.


2021 ◽  
Vol 22 (19) ◽  
pp. 10381
Author(s):  
Lorenzo Salvati ◽  
Lorenzo Cosmi ◽  
Francesco Annunziato

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease and significantly impacts patients’ lives, particularly in its severe forms. AD clinical presentation varies over the course of the disease, throughout different age groups, and across ethnicities. AD is characterized by a spectrum of clinical phenotypes as well as endotypes. Starting from the current description of AD pathogenesis, this review explores the rationale of approved AD therapies from emollients to biologicals and introduces novel promising drugs.


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