Skin Condition
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Polymers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 3671
Saerom Park ◽  
Dahun Jung ◽  
Hyejin Do ◽  
Jonghyeon Yun ◽  
Dongjun Lee ◽  

In this study, a laccase-mediator system (LMS) using a natural mediator was developed as a whitening agent for melanin decolorization. Seven natural mediators were used to replace synthetic mediators and successfully overcome the low redox potential of laccase and limited access of melanin to the active site of laccase. The melanin decolorization activity of laccases from Trametes versicolor (lacT) and Myceliophthora thermophila (lacM) was significantly enhanced using natural mediators including acetosyringone, syringaldehyde, and acetovanillone, which showed low cytotoxicity. The methoxy and ketone groups of natural mediators play an important role in melanin decolorization. The specificity constants of lacT and lacM for melanin decolorization were enhanced by 247 and 334, respectively, when acetosyringone was used as a mediator. LMS using lacM and acetosyringone could also decolorize the melanin present in the cellulose hydrogel film, which mimics the skin condition. Furthermore, LMS could decolorize not only synthetic eumelanin analogs prepared by the oxidation of tyrosine but also natural melanin produced by melanoma cells.

2021 ◽  
Vol 4 ◽  
pp. 86-93 ◽  
Sanjukta Mandal ◽  
Bikash Biswas ◽  
Jahir Abbas

Atopic dermatitis (AD) is a chronic, relapsing pruritic skin condition which is accompanied by inflammation of the affected parts. It usually develops during early childhood and has a predilection for the skin flexures. Approximately 70% of cases start before the age of 5 years: Only 10% begin in adulthood. Asthma and allergic rhinitis are comorbid in most cases. This is a case report of a 2-year-old child who presented with reddish elevated papular eruptions on the skin with severe itching. After thorough case taking and examination, the diagnosis was AD, based on the Hanifin and Rajka criteria. The patient underwent individualised homoeopathic treatment. In subsequent follow-ups, the patient’s improvement was monitored using the PO-SCORAD scale and the subjective symptoms. Marked improvement was noted within a few months. Homoeopathic treatment is effective in these cases to yield rapid improvement without any adverse effects.

Medicina ◽  
2021 ◽  
Vol 57 (10) ◽  
pp. 1133
Aleksander Obtulowicz ◽  
Pawel Dubiela ◽  
Wojciech Dyga ◽  
Kamila Migacz-Gruszka ◽  
Tomasz Mikolajczyk ◽  

Background and Objectives: Chronic spontaneous urticaria (CSU) is a distressing skin condition, which manifests as red, swollen, itchy, and sometimes painful hives or wheals appearing on skin. Recently, CSU has been associated with bradykinin release, which was previously discovered to be the main trigger of hereditary angioedema attacks. To study the role of bradykinin receptors 1 (BR1) and 2 (BR2) in the etiopathogenesis of CSU. Materials and Methods: A total of 60 individuals, 30 patients with CSU and 30 healthy subjects, were recruited to the study. CSU was diagnosed in accordance with the standardized protocol of dermatological assessment of skin symptoms. The level of bradykinin receptors was determined in populations of CD3+, CD4+, and CD8+ lymphocytes as well as in CD14++CD16−, CD14++CD16+ and CD14+CD16+ monocytes. In addition, urticaria activity score summed over 7 days (UAS-7) was assessed and correlated with BR1 and BR2 expression. Results: A statistically significant higher concentration of BR1 expression in lymphocytes was found in patients with CSU, compared to the control group (p < 0.001). Moreover, a statistically significant positive correlation was observed between UAS-7 and BR1/BR2 expression in CD14++CD16− cells (p = 0.03, R = 0.4). Conclusions: Bradykinin receptors are elevated in selected populations of lymphocytes in symptomatic CSU patients compared to healthy controls, indicating their role in the etiopathogenesis of the disease.

Materials ◽  
2021 ◽  
Vol 14 (20) ◽  
pp. 6031
Malgorzata Zimniewska ◽  
Mariola Pawlaczyk ◽  
Barbara Romanowska ◽  
Agnieszka Gryszczyńska ◽  
Edyta Kwiatkowska ◽  

Hemp fiber variety, Bialobrzeskie, contains phenolic acids in its chemical composition giving it inherent antioxidant and antibacterial activity. The use of this raw material in fabric manufacture allows the creation of functional clothing with a positive effect on human skin. The aim of the study was to develop biologically active functional clothing made of pure industrial hemp raw materials, where cannabidiol (CBD) extract applied on the fabric surface strengthened the fiber bioactivity. The design of the clothing technology was focused on keeping the hemp inherent properties on a steady level and avoiding the use of chemicals in each stage of the value chain from plant cultivation up to garment manufacture. The research covered the evaluation of phenolic acids content and The Ferric Ion Reducing Antioxidant Power FRAP antioxidant activity of the hemp fabric. The hemp fabric enriched with CBD was used for clothing preparation. The human trials covered wearing of the clothing by 15 volunteers for six weeks and evaluation of hemp garment effect on human skin. The skin parameters were tested twice, before and after six weeks of clothing wearing, according to the own methodology that included measurements of skin biophysical properties including tests of skin moisture, transepidermal water loss, and sebum. Also, the effect of the active substances present on the fabrics on the in vitro culture of human keratinocytes was evaluated. Results of the research proved, that the wearing of developed functional hemp clothing with CBD extracts applied on the fabric surface was safe and caused improvement of skin condition, which can have an influence on slowing down of skin aging. The invention covering the pure hemp functional clothing with hybrid bioactivity resulting from the joined activity of fiber and cannabidiol was applied for a patent, Patent Application No: P.438388, 2021.

2021 ◽  
Vol 10 (5) ◽  
pp. 217-223
Kamila Ranosz ◽  
Beata Malara ◽  

Acne vulgaris is a common condition that affects both men and women of all age groups. As a result of the outbreak of the COVID-19 pandemic and the introduction of restrictions, mainly the obligation to cover the nose and mouth with protective masks, a large percentage of the population is now struggling with acne. The aim of the research was to determine the opinion on the impact of wearing protective masks on the deterioration of the skin condition and the awareness of the respondents about the treatments and preparations used in acne therapy. The article also attempted to explain the causes of acne lesions.

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Mohamed Abd Alnaeem Sallam ◽  
Mohamed Taha Mahmoud El-sayed ◽  
Ahmed Abd Elfattah Afify ◽  
Mustafa Nooruldeen Abdulqader Mustafa

Abstract Background Seborrheic dermatitis (SD) is a subacute or chronic superficial inflammatory skin condition, characterized by pruritic, erythematous plaques with greasy, yellow-gray scales, which appear on areas rich in sebaceous glands such as the face, scalp, upper chest, and back. Aim of the Work To identify Malassezia species that are involved in the development of SD in different body sites (face, scalp and trunk) and in different age groups, by using Chrom agar. Patients and Methods Forty nine patients with seborrheic dermatitis attending dermatology outpatient clinic in Ain shams university hospital the samples collected from December 2018 to June 2019. Results In this study, the most affected areas were the scalp and other sites as face and ears, which is concordant with the majority of studies worldwide. The role of sex in propensity to the development of Malassezia spp. Infection in SD is still unclear. Conclusion The distribution of Malassezia spp. on healthy and diseased skin shows significant variation and differences, although our knowledge of Malassezia yeasts has increased tremendously during the last two decades, their pathological roles remain ambiguous, and there is currently no conclusive evidence that any given species is responsible for a specific disease.

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Mahmoud Abdel Reheem Abdallah ◽  
Azza Esmat Mostafa ◽  
Shawkat Mohammad Abdel Hameed Mohammad

Abstract Background Striae distensae are a well-recognized, common skin condition that rarely causes any significant medical problems but are often a significant source of distress to those affected. The natural evolution of striae is from red or purple, raised wavy lesions (striae rubra) to white atrophic lesions with wrinkly surface (striae alba). Objectives The present study was designed to compare the efficacy of fractional CO2 laser alone or combined with lyophilized growth factors or to its efficacy alone in the treatment of striae distensae. Patients and Methods The present study included 20 female patients with SD; they were all recruited from Dermatology Outpatient Clinic, Ain Shams University from may 2017 to march 2018. An informed consent for treatment, photography and punch biopsy was taken before enrollment and the study was approved by Dermatology Research Ethical Committee. Results The present study showed statistically significant clinical and histopathological improvement in areas A and B after treatment. This impronment was in rubra more than alba. Area C showed no clinical and histopathological improvement. Area B showed better results than area A.We propose that LGF alone did not show clinical or histopathologiacl improvement. Treatment was tolerated well by all patients where side effects were minimal in the form of transient PIH that resolved after using bleaching creams. There was no statistically sgnificant difference in the incidence of PIH between areas A& B. Conclusion We concluded that fractional CO2 alone is effective in treatment of SD especially stria rubra in skin type III and IV.

2021 ◽  
Olivia Hughes ◽  
Rachael Hunter

BACKGROUND Psoriasis is a chronic inflammatory skin condition, which can be affected by stress. Living with psoriasis can trigger negative emotions, which may influence quality of life. OBJECTIVE This study explored the experiences of people with psoriasis with attention to the potential role of anger in the onset and progression of the chronic skin condition. METHODS Semi-structured qualitative interviews were conducted with twelve participants (n=5 females, n=7 males) recruited online from an advert on a patient charity’s social media platforms. Data were transcribed and analysed using thematic analysis. RESULTS Four key themes were identified: (1) ‘I get really angry with the whole situation:’ anger at the self and others, (2) the impact of anger on psoriasis: angry skin, (3) shared experiences of distress, and (4) moving past anger to affirmation. CONCLUSIONS Findings suggest that anger can have a perceived impact on psoriasis through contributing to sensory symptoms and unhelpful coping cycles and point to a need for enhanced treatment with more psychological support. The findings also highlight the continued stigma which exists for people living with skin conditions and how this may contribute to, and sustain, anger for those individuals. Future research could usefully focus on developing targeted psychosocial interventions to promote healthy emotional coping with psoriasis.

2021 ◽  
Vol 19 (3) ◽  
pp. 445-457
Do-Eun Kim ◽  
Young-Sam Kim

Purpose: This study seeks to discover how customized smart beauty recognition can produce positive results, and to demonstrate that it affects brand attitudes and purchasing intentions of buyers. Pine & Gilmore's experience theory will be used as a basis for this study. This study focuses on customized cosmetics as a type of beauty product.Methods: Data were gathered from 255 women between the ages 20 and 40 from all over Korea. Different tools were used to analyze the data, including the SPSS WIN 21.0 program, Varimax for regression analysis, and Cronbach's α coefficient for reliability analysis. Differences in characteristics were conducted using a one-way-ANOVA, follow-up verification, and correlation analysis between variables and influence verification.Results: Customized cosmetics helped accurately diagnose and prescribe the consumer’s condition with measuring devices. The smart beauty service that the consumer’s experienced was face measurement and virtual makeup. In the future, the consumer ’s would like to experience the effect of skin care before and after skin condition measurement as a smart beauty service. Looking at the impact of Fine & Gilmore's theory of experience economy on brand attitude and purchase intention, the higher the educational experience (β=0.313), the more realistic the experience (β=0.195), the higher the aesthetic experience (β=.357) and the higher the brand attitude (β=0.667). The intention to purchase clearly increases with these positive experiences.Conclusion: This study concluded that although customized cosmetics are highly reliable but expensive, buyers still want to purchase them at a reasonable price. It was also discovered that smart beauty services want improvements in measurement errors, the reliability of the information provided, and the ability to perform additional comparative analysis. Moreover, like Pine & Gilmore's theory of experience economy, it was determined that the higher the satisfaction consumers have after their experience, the higher the brand image and the intention to purchase. We hope to use this theory as important information for continuing research in the beauty industry.

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