The role of Dwaya Haridra with Nimbadi tail in the management of of vicharchika W.S.R. to Eczema

ABSTRACT In ayurveda all skin diseases describes under the heading of kushta . "Kushnatee iti kushtham." ( Ma.Ni/kushta/Tika 1) The disease that destroyes the affected part of skin . Both charak samhita and sushrut samhita classify skin disease into 2 categories . 1) Mahakushtha (major) 2) Kshudrakushtha (minor) ....... Ch.ni 5/4 Ayurvedically, Eczema is considered to be a type of kushtha. i. e.type of kushdrakushtha which is disease of the skin .It is also known as a type of twak roga .which also signifies that it is a skin disease that twak translates to skin and rog translates to pain . Vicharchika is characterised by the following symptoms ati kandu ,bahu strav ,rukshta ,shyavata ,pidika,raji. As described in terms od nidan ,purvarupa,samprapti and chikitsa vicharchika can most certainly be corelated with the modern interpretation of eczema or atopic dermatitis .Eczema or atopic dermatitis is chronic inflammatory skin condition. Atopic dermatitis is characterised by cracked or scaly skin discolored patches,erythma(red skin),papules, exudate(oozing) and intence pruritus (itching ).

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Possible Role of Leptin in Atopic Dermatitis: A Literature Review

Biomolecules ◽

10.3390/biom11111642 ◽

2021 ◽

Vol 11 (11) ◽

pp. 1642

Author(s):

Carlos Jiménez-Cortegana ◽

Germán Ortiz-García ◽

Amalia Serrano ◽

David Moreno-Ramírez ◽

Víctor Sánchez-Margalet

Keyword(s):

Atopic Dermatitis ◽

Skin Disease ◽

Skin Diseases ◽

Allergic Diseases ◽

Developed Countries ◽

Low Grade ◽

New Biomarkers ◽

Age Range ◽

High Degree

Atopic dermatitis (AD) is the most frequent chronic inflammatory skin disease, and its incidence has been rapidly increasing in developed countries in the last years. AD presents a high degree of heterogeneity due to biases and confounding factors such as age range, sex, or ethnicity. For those reasons, the search for new biomarkers is crucial. At the same time, obesity, which is a global health problem, has also increased over the years. It has been associated with many pathophysiological states, including skin diseases such as AD, mostly in childhood. Obesity promotes a low grade inflammation driven by many different cytokines and adipokines, including leptin, which has a key role in many other diseases due to its pleiotropic effects. Leptin also has a role in both skin and allergic diseases very related to AD. Thus, this adipokine could have an important role in the pathogenesis of AD, especially in its chronicity. Despite the limited literature available, there is some evidence that leads us to consider leptin as an important adipokine in this skin disease. For this reason, here we have reviewed the role of leptin in the pathophysiology of AD.

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The role of IL-36γ/IL-1F9 in developing erythroderma in patients with psoriasis

Kazan medical journal ◽

10.17750/kmj2015-080 ◽

2015 ◽

Vol 96 (1) ◽

pp. 80-84

Author(s):

D V Zaslavskiy ◽

I N Chuprov ◽

A A Sydikov ◽

K U Ibragimov ◽

P Wolkenstein ◽

...

Keyword(s):

Skin Disease ◽

Skin Diseases ◽

Drug Hypersensitivity ◽

Hypersensitivity Syndrome ◽

Specific Marker ◽

Inflammatory Skin Disease ◽

Inflammatory Skin Diseases ◽

Inflammatory Skin ◽

Underlying Diseases

Erythroderma is the term used for naming any inflammatory skin disease affecting over 90% of cutaneous surface. Numerous etiologic factors may background erythroderma; however, this condition is most often associated with such underlying diseases as eczema, drug hypersensitivity syndrome, cutaneous epidermotropic lymphoma, photosensitization. Being the most severe clinical form of psoriasis, psoriatic erythroderma may be a life hazard in patients with psoriasis, requiring admission and systemic treatment. The paper reviews modern data on psoriasis and psoriatic erythroderma pathogenesis. The biological role of IL-36γ/IL-1F9 - novel specific marker of psoriasis - is described in detail. Data of researches of this marker in different forms of inflammatory skin disease are discussed. Unlike other earlier described markers of psoriasis, for example, S100 A7, A8, A9 proteins, IL-36γ was highly specific to psoriasis, and rarely found at other inflammatory skin diseases (atopic dermatitis, contact dermatitis). The role of IL-36γ in diagnosing erythroderma in patients with psoriasis is described. The most specific and promising marker for distinguishing psoriatic erythroderma from other forms of erythroderma, IL-36γ can be detected at early stages of the disease, allowing to administer early causative treatment, improving treatment effect and preventing complications.

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IL-13 antagonists in the treatment of atopic dermatitis

Immunotherapy ◽

10.2217/imt-2020-0253 ◽

2021 ◽

Vol 13 (4) ◽

pp. 327-344

Author(s):

Carla Tubau ◽

Lluís Puig

Keyword(s):

Monoclonal Antibody ◽

Clinical Trials ◽

Atopic Dermatitis ◽

Small Molecules ◽

Skin Disease ◽

Skin Diseases ◽

Inflammatory Skin Disease ◽

Receptor Alpha ◽

Inflammatory Skin

Atopic dermatitis (AD) is a prevalent inflammatory skin disease. IL-13 contributes significantly to the pathogenesis of AD in several ways, and beneficial results have been demonstrated with anti-IL-13 therapies. Currently, the only monoclonal antibody (mAb) approved for AD treatment is dupilumab, an antagonist of the IL-4 receptor alpha (IL-4Rα) subunit common to IL-4 and IL-13 receptors, but clinical trials evaluating anti-IL-13 mAbs are providing promising results. The topics of this review will be mAbs targeting IL-13 for the treatment of AD such as dupilumab, tralokinumab and lebrikizumab, small molecules targeting the IL-13 pathway, and a brief explanation of therapies targeting IL-13 for the treatment of other skin diseases.

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Management of Palmo-Plantar Psoriasis by Classical Shodhan and Shaman Chikitsa- A Case Report

International Journal of Ayurvedic Medicine ◽

10.47552/ijam.v12i1.1477 ◽

2021 ◽

Vol 12 (1) ◽

pp. 166-170

Author(s):

Anagha S Hirapure ◽

Saurabh Deshmukh ◽

Trupti Thakre

Keyword(s):

Mental Health ◽

Case Report ◽

Severe Pain ◽

Functional Disability ◽

Skin Diseases ◽

Lifestyle Modification ◽

Skin Condition ◽

Treatment Modalities ◽

Specific Line

Background: Palmo-plantar psoriasis in a non-inflammatory skin condition in which it is capable to produce functional disability. It is the type of psoriasis which occurs in palms and soles together with features like scaling, erythema and itching, pustules cracked & pain, and is limited. Palmo-plantar is the disease which does not have a specific line of treatment, but can be assessed and treated with classical line of Ayurvedic management. This Palmo-plantar not only affects physically but also disturbs the mental health of patient In Ayurveda all the skin diseases are described under single topic; Kushtha (Skin disorders). As Palmo-Plantar psoriasis is compared with Vipadika Kshudra Kushta (cracked bilateral soles & palms) in Ayurveda, the predominant Dosha’s (fundamental bodily bio-elements) are Vata (governs movement of body & mind) & Kapha (controls immune system) in which Vaman Karma (Emesis) is useful. Aim: To evaluate the role of Ayurveda treatment modalities in Vipadika Kshudra Kushta. Materials & Methods: A case report of 56 year old male patient suffering from scaling of both palms and soles with severe pain since 16 years is presented in this article where the patient got satisfactory relief by adopting Shodhan Karma (purification treatment) followed by Shaman Chikitsa (pacifying treatment) with dietary and behavioral lifestyle modification. The symptoms were reduced by Vaman procedure. Result: Patient got about 80% relief after the treatment by which one can say that the palmo-plantar psoriasis can be treated by Ayurveda Medicine.

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PSYCHOSOCIAL IMPACT OF COMMON SKIN DISORDERS – A REVIEW STUDY

November 2020 - International Ayurvedic Medical Journal ◽

10.46607/iamj2009072021 ◽

2021 ◽

Vol 9 (7) ◽

pp. 1452-1456

Author(s):

Manish Choudhari ◽

Nikita Jamadari ◽

Naresh Jain

Keyword(s):

Quality Of Life ◽

Atopic Dermatitis ◽

Skin Disease ◽

Skin Diseases ◽

Fungal Infections ◽

Acne Vulgaris ◽

Well Being ◽

Psychosocial Impact ◽

Common Skin

Objective - To increase awareness of the psychosocial impact of Kushtha, Visarpa, Mukhadushika, Sheetpitta, Udarda and Kotha in Ayurveda and Acne vulgaris, Urticaria, Various types of fungal infections, Atopic dermatitis, Psoriasis etc. in modern point of view. Quality Of Evidence - A literature review was based on a MEDLINE search (1966 to 2000). Selected articles from the dermatologic and psychiatric literature, as well as other relevant medical journals, were reviewed and used as the basis for discussion of how skin disease affects patients’ lives and of appropriate management. Message - Dermatologic problems hurt patients’ quality of life. skin disease can produce stress, anxiety, anger, depression, low self-esteem, embarrassment, and other psychological, personal, professional and social life problems that affect patients’ lives in ways comparable to arthritis or other disabling illnesses, as well as showing a bidirectional relationship between skin disease and psychological distress. This review focuses on the effects of five common skin diseases seen by family physicians- Acne, Urticaria, Various types of fungal infections, Atopic dermatitis and Psoriasis. Conclusion - How skin disease affects psychosocial well-being is un- derappreciated. Increased understanding of the psychiatric comorbidity associated with skin disease and a biopsy- chosocial approach to management will ultimately improve patients’ lives. Keywords: Skin disease, Psychosocial Impact, Quality of life.

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