Flavonoids Present in Propolis in the Battle against Photoaging and Psoriasis

The skin is the main external organ. It protects against different types of potentially harmful agents, such as pathogens, or physical factors, such as radiation. Skin disorders are very diverse, and some of them lack adequate and accessible treatment. The photoaging of the skin is a problem of great relevance since it is related to the development of cancer, while psoriasis is a chronic inflammatory disease that causes scaly skin lesions and deterioration of the lifestyle of people affected. These diseases affect the patient’s health and quality of life, so alternatives have been sought that improve the treatment for these diseases. This review focuses on describing the properties and benefits of flavonoids from propolis against these diseases. The information collected shows that the antioxidant and anti-inflammatory properties of flavonoids play a crucial role in the control and regulation of the cellular and biochemical alterations caused by these diseases; moreover, flavones, flavonols, flavanones, flavan-3-ols, and isoflavones contained in different worldwide propolis samples are the types of flavonoids usually evaluated in both diseases. Therefore, the research carried out in the area of dermatology with bioactive compounds of different origins is of great relevance to developing preventive and therapeutic approaches.

Management of New Born with Harlequin Ichthyosis: A Rare Disease Condition

Harlequin ichthyosis is the most severe form of non-bullous ichthyosis, which is unusual in newborns and is usually marked by deadly excessive keratinization of the skin. Ichthyosis is a family of genetic skin disorders, characterized by dry, thickened, scaly skin with severe morbidity and mortality. The term “harlequin” derives from the facial appearance and the triangular and diamond-shaped pattern of the scaly skin. It occurs in about 1 in 300,000 births and has no known sex predilection. The disorder affects the skin in utero causing thick, horny, armory-like plates that cover the skin with contraction abnormalities of the eyes, ears, mouth and appendages. There is no specific guideline to manage the newborn of harlequin ichthyosis, in that nursing care is most important in the initial phase. There are required multi-disciplinary teams to take care of harlequin ichthyosis.

HI (HARLEQUIN ICHTHYOSIS) BABY

HI is a very rare type of genetical abnormality but can be seen and scared by seeing various social media footages. It is associated with deletion and truncation mutations of a keratinocyte lipid transporter. Harlequin disorder is categorized by diffuse epidermal hyperkeratinization along with defective desquamation. During birth, the HI phenotype is conspicuous with thick hyperkeratotic plate-like scales with deep dermal ssures, severe ectropion and eclabium, among other ndings. In this ichthyosis marked eclabium and ectropion are present secondary to the taut as well as in the unyielding skin. The ears may be inattentive, absent or poorly developed. Even the arms, feet, and digits have exion contractures and may be hypoplastic. The skin wall is harshly compromised, leading to undue water loss, causes electrolyte abnormalities, temperature alteration and an increased risk of deadly infection. Some of the primary treatments are smearing retinoids application for shedding the hard and scaly skin, topical antibiotics application can prevent infection, insertion an ET tube in the airway to assistance with breathing, applying lubricating eye drops or protective devices on the eyes. Following ongoing treatment like humidied incubator (for premature infants), continuous monitoring of TPR and SpO2, early intubation(optional), frequent cultures of the skin should be taken for lab testing, monitoring serum electrolyte levels, maintaining a germ-free environment to evade infection etc.

A Novel Light Weight Approach For Identification of Psoriasis Affected Skin Lesion Using Deep Learning.

Psoriasis is a skin disorder which affects the people physically, mentally and emotionally. It is characterized as rough elevated scaly skin which is evident from surrounding skin area. There are various types of psoriasis which include plaque psoriasis, nail psoriasis, guttate psoriasis, inverse psoriasis, pustular psoriasis, erythrodermic psoriasis and psoriatic arthritis. The common trend observed is that the people tend to face difficulties in differentiating and tracking the disorder which will worsen the situation of the affected skin. It is essential to keep track of the affected skin for the prognosis of the disorder. In this work, an attempt is made to identify the psoriasis affected area automatically using MobileNet machine learning model which will become an objective tool in accurate identification of the disorder which in turn helps in effective treatment of the disorder.

The role of Dwaya Haridra with Nimbadi tail in the management of of vicharchika W.S.R. to Eczema

ABSTRACT In ayurveda all skin diseases describes under the heading of kushta . "Kushnatee iti kushtham." ( Ma.Ni/kushta/Tika 1) The disease that destroyes the affected part of skin . Both charak samhita and sushrut samhita classify skin disease into 2 categories . 1) Mahakushtha (major) 2) Kshudrakushtha (minor) ....... Ch.ni 5/4 Ayurvedically, Eczema is considered to be a type of kushtha. i. e.type of kushdrakushtha which is disease of the skin .It is also known as a type of twak roga .which also signifies that it is a skin disease that twak translates to skin and rog translates to pain . Vicharchika is characterised by the following symptoms ati kandu ,bahu strav ,rukshta ,shyavata ,pidika,raji. As described in terms od nidan ,purvarupa,samprapti and chikitsa vicharchika can most certainly be corelated with the modern interpretation of eczema or atopic dermatitis .Eczema or atopic dermatitis is chronic inflammatory skin condition. Atopic dermatitis is characterised by cracked or scaly skin discolored patches,erythma(red skin),papules, exudate(oozing) and intence pruritus (itching ).

Harlequin fetus – Icthyosis fetalis: Case report

We are presenting a newborn with a very rare and most severe form of congenital ichthyosis that is characterized by a thick, heavily keratinized and scaly skin.

Study of Allergic Rhinitis by using RAP Questionnaire and Skin Lesions in a Group of Shoe Factory Workers in India: A Cross-sectional Study

Background: The footwear industry is a significant segment of leather industry in India. Workers in shoe industry are exposed to mixtures of organic solvents used for colouring, adhesion, cleaning and fumes which could lead to respiratory and skin problems. Objectives: To study allergic rhinitis symptoms and examine skin lesions in workers exposed to harmful agents in footwear industry. Methodology: It is a cross-sectional study conducted in November 2018 for 4 days among industrial workers in a selected factory of Footwear Park, developed by the Haryana State Industrial Development Corporation (HSIDC) of Bahadurgarh. RAP (Respiratory Allergy Prediction test) questionnaire for allergic rhinitis and questions on type and number of skin lesions were asked. Result: 51 workers were selected for the study. Workers involved in printing and moulding responded positively to one or more than one questions of RAP questionnaire used for screening allergic rhinitis. 31.4% had itching, 27.5% had papules, 7.8% had blisters, 7.8% had oozing, and 15.7% had dry/ scaly skin. Itching, papules, blisters, oozing, and dry/ scaly skin were found only on the head/ neck, hands and arms/ forearms with no involvement of lower legs and trunk. Skin problems like itching and papules were significantly associated with printing and moulding of shoes (p < 0.05). Conclusion: Shoe-making involves exposure to many hazardous compounds and toxic fumes that may cause allergic rhinitis as well as skin allergies in the form of skin lesions especially those involved in printing and moulding of shoes.

Novel Homozygous Mutations in the Genes TGM1, SULT2B1, SPINK5 and FLG in Four Families Underlying Congenital Ichthyosis

Background: Ichthyoses are a large group of hereditary cornification disorders, which are both clinically and etiologically heterogeneous and affect mostly all the skin surface of the patients. Ichthyosis has its origin in an ancient Greek word “ichthys” meaning fish, this is because the ichthyosis patients have dry, thickened, and scaly skin. There is an excess accumulation of epidermal cells resulting in the appearance of continuous and widespread scales on the body. There are many varieties of ichthyosis with a broad spectrum of intensity, severity, and associated symptoms, most of them are extremely rare. Ichthyosis vulgaris is the most frequently occurring type of ichthyoses. Method: The present study consists of four Pakistani ichthyosis families (A, B, C, and D). Whole exome sequencing (WES) approach was used to identify the pathogenic sequence variants in probands. The segregation of these variants in other participants was confirmed by Sanger sequencing. Results: Total four variants including, two splice site (TGM1: c.2088 + 1G > A) and (SPINK5: c.882 + 1G > T), a missense (SULT2B1: c.419C > T; p. Ala140Val), and a nonsense (FLG: c.6109C > T; p. Arg2037Ter) variant were identified in families A, C, B, and D, respectively, as causative mutations responsible for ichthyosis in these families. Conclusion: Our study unravels the molecular etiology of the four Pakistani ichthyosis families and validates the involvement of TGM1, SULT2B1, SPINK5, and FLG, in the etiology of different forms of ichthyosis. In addition, this study also aims to give a detailed clinical report of the studied ichthyosis families.

Extremely preterm infant with persistent peeling skin: X-linked ichthyosis imitates prematurity

Objectives X-linked ichthyosis (XLI) is a genetic disorder caused by a deficiency in steroid sulfatase, an enzyme which catalyzes a reaction in estrone synthesis. The disorder primarily manifests as dry, scaly skin which may be difficult to diagnose in extremely preterm infants, as the dermatological features may be falsely attributed to a normal variant of skin for this population. Case presentation In this case report, we describe a male with XLI, born at 24 weeks gestation, who had persistent dry, flaky and hyperpigmented skin. This case is notable for the age of diagnosis in an extremely premature infant; day of life 105. In addition, this infant experienced out of proportion bronchopulmonary symptoms that we postulate may be linked to the steroid sulfatase deficiency, as estrogen is a mediator of surfactant production. Conclusions This report underscores the need to potentially evaluate persistent dry, flaky skin in the preterm infant, as XLI may also impact long term neurodevelopmental outcomes.