Ageing and spatial reversal learning in humans: Findings from a virtual water maze

Spatial reversal learning was explored for mice genetically selected for high brain weight and unselected control mice with lower brain weights. Original learning and two reversals were presented in a water maze. There were no differences for original learning, but the high brain-weight mice were superior to the unselected controls for both reversals. Since all controls had lower brain weights than the highs, it was concluded that these data support a positive relation between brain size and spatial reversal learning.

Download Full-text

Hippocampal long-term depression mediates spatial reversal learning in the Morris water maze

Neuropharmacology ◽

10.1016/j.neuropharm.2012.06.027 ◽

2013 ◽

Vol 64 ◽

pp. 65-73 ◽

Cited By ~ 111

Author(s):

Zhifang Dong ◽

Yanrui Bai ◽

Xiaoyan Wu ◽

Hongjie Li ◽

Bo Gong ◽

...

Keyword(s):

Morris Water Maze ◽

Reversal Learning ◽

Water Maze ◽

Long Term Depression ◽

Spatial Reversal

Download Full-text

Roles of the ventral hippocampus and medial prefrontal cortex in spatial reversal learning and attentional set-shifting

Neurobiology of Learning and Memory ◽

10.1016/j.nlm.2021.107477 ◽

2021 ◽

pp. 107477

Author(s):

Daniela Cernotova ◽

Ales Stuchlik ◽

Jan Svoboda

Keyword(s):

Prefrontal Cortex ◽

Medial Prefrontal Cortex ◽

Reversal Learning ◽

Ventral Hippocampus ◽

Set Shifting ◽

Attentional Set ◽

Spatial Reversal ◽

Attentional Set Shifting

Download Full-text

Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APPNL-F/NL-F knock-in mice

Scientific Reports ◽

10.1038/s41598-018-24657-9 ◽

2018 ◽

Vol 8 (1) ◽

Cited By ~ 12

Author(s):

Disha Shah ◽

Amira Latif-Hernandez ◽

Bart De Strooper ◽

Takashi Saito ◽

Takaomi Saido ◽

...

Keyword(s):

Functional Connectivity ◽

Reversal Learning ◽

Spatial Reversal

Download Full-text

Complex Behavioral Strategy and Reversal Learning in the Water Maze without NMDA Receptor-Dependent Long-Term Potentiation

Journal of Neuroscience ◽

10.1523/jneurosci.19-10-j0003.1999 ◽

1999 ◽

Vol 19 (10) ◽

pp. RC2-RC2 ◽

Cited By ~ 35

Author(s):

Tim Hoh ◽

Jason Beiko ◽

Francis Boon ◽

Susannah Weiss ◽

Donald P. Cain

Keyword(s):

Nmda Receptor ◽

Reversal Learning ◽

Water Maze ◽

Long Term Potentiation ◽

Behavioral Strategy ◽

Term Potentiation

Download Full-text

Spatial Discrimination Reversal Learning for Mice Genetically Selected for Differing Brain Size: A Supplementary Report

Perceptual and Motor Skills ◽

10.2466/pms.1970.30.1.239 ◽

1970 ◽

Vol 30 (1) ◽

pp. 239-245 ◽

Cited By ~ 15

Author(s):

Merrill F. Elias

Keyword(s):

Reversal Learning ◽

Water Maze ◽

Brain Size ◽

Discrimination Reversal ◽

Spatial Discrimination ◽

Control Line ◽

Positive Relation ◽

High Brain ◽

High Line ◽

Supplementary Report

Spatial discrimination reversal learning was explored for mice genetically selected for high brain weight and unselected controls with lower brain weights. Control-line Ss escaped from a water maze more rapidly, but high-line Ss made fewer errors and took less trials to reach criterion on the first reversal. Control-line Ss were unable to complete more than 1 reversal, while high-line Ss all completed at least 7 reversals. This positive relation between reversal learning and brain size is consistent with comparisons among species and experiments manipulating brain size by means of drugs or surgery.

Download Full-text