Effects of the NMDA receptor antagonists dizocilpine and Ro 63-1908 on delay-discounting and risky decision-making in a gambling task

2018 ◽  
Vol 348 ◽  
pp. 201-210 ◽  
Author(s):  
Guy A. Higgins ◽  
Leo B. Silenieks ◽  
Cam MacMillan ◽  
Fiona D. Zeeb ◽  
Sandy Thevarkunnel
Keyword(s):  
Decision Making ◽  
Nmda Receptor ◽  
Delay Discounting ◽  
Nmda Receptor Antagonists ◽  
Gambling Task ◽  
Risky Decision Making ◽  
Receptor Antagonists ◽  
Risky Decision

scholarly journals Risky decision making assessed with the gambling task in adults with HIV.

2006 ◽  
Vol 20 (3) ◽  
pp. 355-360 ◽  
Author(s):  
David J. Hardy ◽  
Charles H. Hinkin ◽  
Andrew J. Levine ◽  
Steven A. Castellon ◽  
Mona N. Lam
Keyword(s):  
Decision Making ◽  
Gambling Task ◽  
Risky Decision Making ◽  
Risky Decision

Alpha-synuclein deletion decreases motor impulsivity but does not affect risky decision making in a mouse Gambling Task

2014 ◽  
Vol 231 (12) ◽  
pp. 2493-2506 ◽  
Author(s):  
Yolanda Peña-Oliver ◽  
Sandra Sanchez-Roige ◽  
David N. Stephens ◽  
Tamzin L. Ripley
Keyword(s):  
Decision Making ◽  
Alpha Synuclein ◽  
Gambling Task ◽  
Risky Decision Making ◽  
Risky Decision ◽  
Motor Impulsivity

Aging and risky decision-making: New ERP evidence from the Iowa Gambling Task

2017 ◽  
Vol 640 ◽  
pp. 93-98 ◽  
Author(s):  
Elisa Di Rosa ◽  
Daniela Mapelli ◽  
Giorgio Arcara ◽  
Piero Amodio ◽  
Stefano Tamburin ◽  
...  
Keyword(s):  
Decision Making ◽  
Iowa Gambling Task ◽  
Gambling Task ◽  
Risky Decision Making ◽  
Risky Decision

Pharmacological evidence of a cholinergic contribution to elevated impulsivity and risky decision-making caused by adding win-paired cues to a rat gambling task

2021 ◽  
pp. 026988112097242
Author(s):  
Graeme D Betts ◽  
Tristan J Hynes ◽  
Catharine A Winstanley
Keyword(s):  
Decision Making ◽  
Visual Cues ◽  
Critical Role ◽  
Sensory Stimulation ◽  
Muscarinic Agonist ◽  
Gambling Task ◽  
Risky Decision Making ◽  
Compulsive Gambling ◽  
Risky Decision ◽  
Motor Impulsivity

Background: Pairing rewards with sensory stimulation, in the form of auditory and visual cues, increases risky decision-making in both rats and humans. Understanding the neurobiological basis of this effect could help explain why electronic gambling machines are so addictive, and inform treatment development for compulsive gambling and gaming. Numerous studies implicate the dopamine system in mediating the motivational influence of reward-paired cues; recent data suggest the cholinergic system also plays a critical role. Previous work also indicates that cholinergic drugs alter decision-making under uncertainty. Aims: We investigated whether the addition of reward-concurrent cues to the rat gambling task (crGT) altered the effects of peripherally administered cholinergic compounds. Methods: Muscarinic and nicotinic agonists and antagonists were administered to 16 male, Long–Evans rats trained on the crGT. Measures of optimal/risky decision-making and motor impulsivity were the main dependent variables of interest. Results: The muscarinic receptor antagonist scopolamine improved decision-making overall, decreasing selection of one of the risky options while increasing choice of the more advantageous options. The muscarinic agonist oxotremorine increased choice latency but did not significantly affect option preference. Neither the nicotinic antagonist mecamylamine nor the agonist nicotine affected choice patterns, but mecamylamine decreased premature responding, an index of motor impulsivity. Conclusions: These results contrast sharply from those obtained previously using the uncued rGT, and suggest that the deleterious effects of win-paired cues on decision-making and impulse control may result from elevated cholinergic tone.

scholarly journals Long-term deficits in risky decision-making after traumatic brain injury on a rat analog of the Iowa gambling task

2019 ◽  
Vol 1704 ◽  
pp. 103-113 ◽  
Author(s):  
Trinity K. Shaver ◽  
Jenny E. Ozga ◽  
Binxing Zhu ◽  
Karen G. Anderson ◽  
Kris M. Martens ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Decision Making ◽  
Brain Injury ◽  
Iowa Gambling Task ◽  
Gambling Task ◽  
Risky Decision Making ◽  
Risky Decision
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