Deep Brain Stimulation of the dorsal raphe abolishes serotonin 1A facilitation of AMPA receptor-mediated synaptic currents in the ventral hippocampus

2021 ◽  
Vol 403 ◽  
pp. 113134
Author(s):  
M.B. Viana ◽  
R.S. Martins ◽  
M.S.C.F. Silva ◽  
S. Xapelli ◽  
S.H. Vaz ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Ampa Receptor ◽  
Brain Stimulation ◽  
Ventral Hippocampus ◽  
Dorsal Raphe ◽  
Synaptic Currents ◽  
Dorsal Raphé ◽  
Deep Brain ◽  
Stimulation Of

Deep brain stimulation of the dorsal raphe inhibits avoidance and escape reactions and activates forebrain regions related to the modulation of anxiety/panic

2017 ◽  
Vol 321 ◽  
pp. 193-200 ◽  
Author(s):  
Tatiana Wscieklica ◽  
Mariana S.C.F. Silva ◽  
Jéssica A. Lemes ◽  
Liana Melo-Thomas ◽  
Isabel C. Céspedes ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Dorsal Raphe ◽  
Dorsal Raphé ◽  
Deep Brain ◽  
Stimulation Of

Deep brain stimulation modulates hypothalamic-brainstem fibers in cluster headache: case report

2020 ◽  
Vol 132 (3) ◽  
pp. 717-720 ◽  
Author(s):  
Sérgio A. F. Dantas ◽  
Eduardo J. L. Alho ◽  
Juliano J. da Silva ◽  
Nilson N. Mendes Neto ◽  
Erich Talamoni Fonoff ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Cluster Headache ◽  
Brain Stimulation ◽  
Clinical Effects ◽  
Chronic Stimulation ◽  
Mammillary Bodies ◽  
Fiber Tracts ◽  
White Matter Region ◽  
Deep Brain ◽  
Stimulation Of

Hypothalamic deep brain stimulation (DBS) has been used for more than a decade to treat cluster headache (CH) but its mechanisms remain poorly understood. The authors have successfully treated a patient with CH using hypothalamic DBS and found that the contact used for chronic stimulation was located in a white matter region posterior to the mammillary bodies. Fiber tracts crossing that region were the medial forebrain bundle and those interconnecting the hypothalamus and brainstem, including the dorsal longitudinal fasciculus. Because the stimulation of axons is an important mechanism of DBS, some of its clinical effects in CH may be related to the stimulation of fibers interconnecting the hypothalamus and brainstem.

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