Growth inhibition of breast epithelial cells by celecoxib is associated with upregulation of insulin-like growth factor binding protein-3 expression

2004 ◽  
Vol 316 (2) ◽  
pp. 421-428 ◽  
Author(s):  
Randy J. Levitt ◽  
Jonathan Buckley ◽  
Marie-José Blouin ◽  
Betty Schaub ◽  
Timothy J. Triche ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Growth Inhibition ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Breast Epithelial Cells ◽  
Factor Binding ◽  
Breast Epithelial

Differential IGF-independent effects of insulin-like growth factor binding proteins (1-6) on apoptosis of breast epithelial cells

1999 ◽  
Vol 75 (4) ◽  
pp. 652-664 ◽  
Author(s):  
Claire M. Perks ◽  
Samantha Bowen ◽  
Zahidah P. Gill ◽  
Paul V. Newcomb ◽  
Jeff M.P. Holly
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Breast Epithelial Cells ◽  
Factor Binding ◽  
Breast Epithelial ◽  
Independent Effects

Expression of a lactogen-dependent insulin-like growth factor-binding protein in cultured mouse mammary epithelial cells.

Endocrinology ◽  
1992 ◽  
Vol 131 (1) ◽  
pp. 261-267 ◽  
Author(s):  
P J Fielder ◽  
G Thordarson ◽  
A English ◽  
R G Rosenfeld ◽  
F Talamantes
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Binding Protein ◽  
Mammary Epithelial ◽  
Insulin Like Growth Factor ◽  
Factor Binding

scholarly journals Growth Inhibition in Giant Growth Hormone Transgenic Mice by Overexpression of Insulin-Like Growth Factor-Binding Protein-2

Endocrinology ◽  
2001 ◽  
Vol 142 (5) ◽  
pp. 1889-1898 ◽  
Author(s):  
Andreas Hoeflich ◽  
Sabine Nedbal ◽  
Werner F. Blum ◽  
Michael Erhard ◽  
Harald Lahm ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Transgenic Mice ◽  
Growth Inhibition ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding

Insulin-like growth factor-binding protein-3 expression and secretion by cultures of human prostate epithelial cells and stromal fibroblasts

1994 ◽  
Vol 141 (3) ◽  
pp. 535-540 ◽  
Author(s):  
R S Birnbaum ◽  
J L Ware ◽  
S R Plymate
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Conditioned Medium ◽  
Binding Protein ◽  
Human Prostate ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Cell Extracts ◽  
Prostate Epithelial Cells ◽  
Igfbp 3

Abstract Prostate-specific antigen (PSA) was recently shown to be an insulin-like growth factor-binding protein (IGFBP)-3 protease. However, only IGFBPs-2 and -4 have been identified in conditioned medium of prostate epithelial cells. Using cultures of human prostate epithelial and stromal fibroblastic cells, we examined conditioned medium and cell extracts for evidence of IGFBP-3 expression and secretion. Western ligand blotting of conditioned medium from epithelial or stromal cultures revealed the presence of IGFBPs in the molecular weight range 36–48 kDa, suggestive of IGFBP-3. Western immunoblots of these media confirmed the presence of IGFBP-3. Northern analyses of extracts of both stromal and epithelial cells showed a 2·5 kb band, the size of IGFBP-3 mRNA. We conclude that prostate cells express IGFBP-3 and that local proteolysis by PSA could modify this binding protein's actions in the prostate. Journal of Endocrinology (1994) 141, 535–540

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