The role of bone marrow-derived cells in bone fracture repair in a green fluorescent protein chimeric mouse model

2005 ◽  
Vol 331 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Kazuhiro Taguchi ◽  
Rei Ogawa ◽  
Makoto Migita ◽  
Hideki Hanawa ◽  
Hiromoto Ito ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Green Fluorescent Protein ◽  
Mouse Model ◽  
Fluorescent Protein ◽  
Fracture Repair ◽  
Chimeric Mouse ◽  
Bone Marrow Derived Cells ◽  
Chimeric Mouse Model ◽  
Green Fluorescent

Systemically Transplanted Bone Marrow–derived Cells Contribute to Dental Pulp Regeneration in a Chimeric Mouse Model

2016 ◽  
Vol 42 (2) ◽  
pp. 263-268 ◽  
Author(s):  
Wenan Xu ◽  
Shan Jiang ◽  
Qiuyue Chen ◽  
Yanyan Ye ◽  
Jiajing Chen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mouse Model ◽  
Dental Pulp ◽  
Chimeric Mouse ◽  
Pulp Regeneration ◽  
Bone Marrow Derived Cells ◽  
Chimeric Mouse Model

scholarly journals Chimeric Mouse model to track the migration of bone marrow derived cells in glioblastoma following anti-angiogenic treatments

2016 ◽  
Vol 17 (3) ◽  
pp. 280-290 ◽  
Author(s):  
B. R. Achyut ◽  
Adarsh Shankar ◽  
A. S. M. Iskander ◽  
Roxan Ara ◽  
Robert A. Knight ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mouse Model ◽  
Chimeric Mouse ◽  
Bone Marrow Derived Cells ◽  
Chimeric Mouse Model

Diminished PDGF‐B expression in bone‐marrow derived cells leads to increased hypoxia‐induced angiogenesis in a novel chimeric mouse model

2008 ◽  
Vol 22 (S2) ◽  
pp. 67-67
Author(s):  
Lydia S. Glaw ◽  
James A. Thomas ◽  
Dominique L. Thacker ◽  
Gary K. Owens ◽  
Thomas C. Skalak
Keyword(s):  
Bone Marrow ◽  
Mouse Model ◽  
Chimeric Mouse ◽  
Bone Marrow Derived Cells ◽  
Chimeric Mouse Model

Defining the Role of Arginine 96 in Green Fluorescent Protein Fluorophore Biosynthesis†,‡

Biochemistry ◽  
2005 ◽  
Vol 44 (49) ◽  
pp. 16211-16220 ◽  
Author(s):  
Timothy I. Wood ◽  
David P. Barondeau ◽  
Chiharu Hitomi ◽  
Carey J. Kassmann ◽  
John A. Tainer ◽  
...  
Keyword(s):  
Green Fluorescent Protein ◽  
Fluorescent Protein ◽  
Green Fluorescent

scholarly journals Stratification of Antigen-presenting Cells within the Normal Cornea

2009 ◽  
Vol 1 ◽  
pp. OED.S2813 ◽  
Author(s):  
Jared E. Knickelbein ◽  
Simon C. Watkins ◽  
Paul G. Mcmenamin ◽  
Robert L. Hendricks
Keyword(s):  
Bone Marrow ◽  
Basement Membrane ◽  
Mhc Class Ii ◽  
Fluorescent Protein ◽  
Antigen Presenting Cells ◽  
Class Ii ◽  
Apical Surface ◽  
Bone Marrow Derived Cells ◽  
Green Fluorescent ◽  
Antigen Presenting

The composition and location of professional antigen presenting cells (APC) varies in different mucosal surfaces. The cornea, long considered an immune-privileged tissue devoid of APCs, is now known to host a heterogeneous network of bone marrow-derived cells. Here, we utilized transgenic mice that express enhanced green fluorescent protein (EGFP) from the CD 11c promoter (pCD11c) in conjunction with immunohistochemical staining to demonstrate an interesting stratification of APCs within non-inflamed murine corneas. pCD11c+ dendritic cells (DCs) reside in the basal epithelium, seemingly embedded in the basement membrane. Most DCs express MHC class II on at least some dendrites, which extend up to 50 μm in length and traverse up 20 μm tangentially towards the apical surface of the epithelium. The DC density diminishes from peripheral to central cornea. Beneath the DCs and adjacent to the stromal side of the basement membrane reside pCD11c–CD11b+ putative macrophages that express low levels of MHC class II. Finally, MHC class II–pCD11c–CD11b+ cells form a network throughout the remainder of the stroma. This highly reproducible stratification of bone marrow-derived cells is suggestive of a progression from an APC function at the exposed corneal surface to an innate immune barrier function deeper in the stroma.

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