Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain

2005 ◽  
Vol 337 (3) ◽  
pp. 892-900 ◽  
Author(s):  
Hitomi Takanaga ◽  
Bryan Mackenzie ◽  
Ji-Bin Peng ◽  
Matthias A. Hediger
Keyword(s):  
Amino Acid ◽  
Human Brain ◽  
Amino Acid Transporter ◽  
Branched Chain Amino Acid ◽  
Acid Transporter ◽  
Branched Chain

scholarly journals Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Philipp Wuggenig ◽  
◽  
Berna Kaya ◽  
Hassan Melhem ◽  
C. Korcan Ayata ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Transporter ◽  
Branched Chain Amino Acid ◽  
Acid Transporter ◽  
Branched Chain

scholarly journals Identification and Functional Characterization of the Lactococcus lactis CodY-Regulated Branched-Chain Amino Acid Permease BcaP (CtrA)

2006 ◽  
Vol 188 (9) ◽  
pp. 3280-3289 ◽  
Author(s):  
Chris D. den Hengst ◽  
Maarten Groeneveld ◽  
Oscar P. Kuipers ◽  
Jan Kok
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Lactococcus Lactis ◽  
Amino Acid Transport ◽  
Amino Acid Transporter ◽  
Acid Transport ◽  
Amino Acid Permease ◽  
Branched Chain Amino Acid ◽  
Acid Transporter ◽  
Branched Chain

ABSTRACT Transcriptome analyses have previously revealed that a gene encoding the putative amino acid transporter CtrA (YhdG) is one of the major targets of the pleiotropic regulator CodY in Lactococcus lactis and Bacillus subtilis. The role of ctrA in L. lactis was further investigated with respect to both transport activity as well as CodY-mediated regulation. CtrA is required for optimal growth in media containing free amino acids as the only amino acid source. Amino acid transport studies showed that ctrA encodes a secondary amino acid transport system that is specific for branched-chain amino acids (BCAAs) (isoleucine, leucine, and valine) and methionine, which is in disagreement with its previously proposed function (a cationic amino acid transporter), which was assigned based on homology. We propose to rename CtrA BcaP, for branched-chain amino acid permease. BcaP is a member of a group of conserved transport systems, as homologs are widely distributed among gram-positive bacteria. Deletion of bcaP resulted in the loss of most of the BCAA uptake activity of L. lactis, indicating that BcaP is the major BCAA carrier of this organism. Deletion of bcaP together with a second (putative) BCAA permease, encoded by brnQ, further reduced the viability of the strain. DNA microarray analysis showed that deletion of bcaP predominantly affects genes belonging to the regulons of the transcriptional regulator CodY, which is involved in global nitrogen metabolism and needs BCAAs for its activation, and of CmbR, which is involved in sulfur amino acid metabolism.

scholarly journals Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells

2002 ◽  
Vol 1565 (1) ◽  
pp. 112-122 ◽  
Author(s):  
Do Kyung Kim ◽  
Yoshikatsu Kanai ◽  
Hye Won Choi ◽  
Sahatchai Tangtrongsup ◽  
Arthit Chairoungdua ◽  
...  
Keyword(s):  
Amino Acid ◽  
Bladder Carcinoma ◽  
Amino Acid Transporter ◽  
Carcinoma Cells ◽  
Human Bladder ◽  
System L ◽  
Acid Transporter ◽  
Bladder Carcinoma Cells

scholarly journals Characterization of the rat neutral and basic amino acid transporter utilizing anti-peptide antibodies.

1993 ◽  
Vol 90 (9) ◽  
pp. 4022-4026 ◽  
Author(s):  
R. Mosckovitz ◽  
N. Yan ◽  
E. Heimer ◽  
A. Felix ◽  
S. S. Tate ◽  
...  
Keyword(s):  
Amino Acid ◽  
Basic Amino Acid ◽  
Amino Acid Transporter ◽  
Acid Transporter ◽  
Peptide Antibodies

scholarly journals Cloning and characterization of a potassium-coupled amino acid transporter

1998 ◽  
Vol 95 (9) ◽  
pp. 5395-5400 ◽  
Author(s):  
M. Castagna ◽  
C. Shayakul ◽  
D. Trotti ◽  
V. F. Sacchi ◽  
W. R. Harvey ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Transporter ◽  
Acid Transporter
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